Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Autor: Chawla, Ajay, Mauer, J, Chaurasia, B, Goldau, J, Vogt, MC, Ruud, J, Nguyen, KD, Theurich, S, Hausen, AC, Schmitz, J, Brönneke, HS

Publikováno v: Chawla, Ajay; Mauer, J; Chaurasia, B; Goldau, J; Vogt, MC; Ruud, J; et al.(2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6dm62296

Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::bb5daf68a59396644aabd64acfa0ca2f
http://www.escholarship.org/uc/item/6dm62296

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

Autor: Ruud J; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Alber J; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Tokarska A; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden., Engström Ruud L; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Nolte H; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Biglari N; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Lippert R; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Lautenschlager Ä; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Cieślak PE; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Szumiec Ł; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Hess ME; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Brönneke HS; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Krüger M; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Nissbrandt H; Department of Pharmacology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, 40530 Gothenburg, Sweden., Korotkova T; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Silberberg G; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden., Rodriguez Parkitna J; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Brüning JC; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address: bruening@sf.mpg.de.

Publikováno v: Cell reports [Cell Rep] 2019 Jun 11; Vol. 27 (11), pp. 3182-3198.e9.

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss.

Autor: Schmitz J; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Evers N; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Awazawa M; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Nicholls HT; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Brönneke HS; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Dietrich A; Department of Surgery, University of Leipzig, Leipzig, Germany., Mauer J; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany., Brüning JC; Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Gleueler Str. 50, D-50931 Cologne, Germany. Electronic address: bruening@sf.mpg.de.

Publikováno v: Molecular metabolism [Mol Metab] 2016 Jan 11; Vol. 5 (5), pp. 328-339. Date of Electronic Publication: 2016 Jan 11 (Print Publication: 2016).

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Autor: Mauer J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany. [4]., Chaurasia B; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2]., Goldau J; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany., Vogt MC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Ruud J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Nguyen KD; Cardiovascular Research Institute, Departments of Physiology and Medicine, University of California, San Francisco, California, USA., Theurich S; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Hausen AC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Schmitz J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne, Cologne, Germany., Brönneke HS; 1] Max Planck Institute for Neurological Research, Cologne, Germany. [2] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Estevez E; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Allen TL; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Mesaros A; Max Planck Institute for Biology of Ageing, Cologne, Germany., Partridge L; Max Planck Institute for Biology of Ageing, Cologne, Germany., Febbraio MA; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Chawla A; Cardiovascular Research Institute, Departments of Physiology and Medicine, University of California, San Francisco, California, USA., Wunderlich FT; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Brüning JC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany. [4] Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany. [5] Center for Molecular Medicine Cologne, Cologne, Germany.

Publikováno v: Nature immunology [Nat Immunol] 2014 May; Vol. 15 (5), pp. 423-30. Date of Electronic Publication: 2014 Mar 30.

Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.

Autor: Zemva J; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Udelhoven M, Moll L, Freude S, Stöhr O, Brönneke HS, Drake RB, Krone W, Schubert M

Publikováno v: Age (Dordrecht, Netherlands) [Age (Dordr)] 2013 Oct; Vol. 35 (5), pp. 1881-97. Date of Electronic Publication: 2012 Nov 17.