Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Autor: Chawla, Ajay, Mauer, J, Chaurasia, B, Goldau, J, Vogt, MC, Ruud, J, Nguyen, KD, Theurich, S, Hausen, AC, Schmitz, J, Brönneke, HS

Publikováno v: Chawla, Ajay; Mauer, J; Chaurasia, B; Goldau, J; Vogt, MC; Ruud, J; et al.(2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6dm62296

Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::bb5daf68a59396644aabd64acfa0ca2f
http://www.escholarship.org/uc/item/6dm62296

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

Autor: Ruud J; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Alber J; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Tokarska A; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden., Engström Ruud L; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Nolte H; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Biglari N; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Lippert R; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Lautenschlager Ä; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Cieślak PE; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Szumiec Ł; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Hess ME; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Brönneke HS; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Krüger M; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Nissbrandt H; Department of Pharmacology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, 40530 Gothenburg, Sweden., Korotkova T; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany., Silberberg G; Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden., Rodriguez Parkitna J; Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland., Brüning JC; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address: bruening@sf.mpg.de.

Publikováno v: Cell reports [Cell Rep] 2019 Jun 11; Vol. 27 (11), pp. 3182-3198.e9.

Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.

Autor: Oliverio M; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Schmidt E; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Mauer J; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany.; Department of Pharmacology, Weill Medical College, Cornell University, New York 10035, USA., Baitzel C; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Hansmeier N; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Khani S; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Konieczka S; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Pradas-Juni M; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Brodesser S; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Van TM; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Bartsch D; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Brönneke HS; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Heine M; Department of Biochemistry and Molecular Cell Biology, University Hospital Hamburg-Eppendorf, D-20246, Germany., Hilpert H; F. Hoffmann-La Roche Ltd, Discovery Chemistry, Pharma Research and Early Development, CH-4070 Basel, Switzerland., Tarcitano E; Department of Biophysics, Federal University of Sao Paulo, Brazil., Garinis GA; Institute of Molecular Biology and Biotechnology (IMBB) Foundation for Research and Technology - Hellas (FORTH) Heraklion, GR-70013, Crete, Greece., Frommolt P; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Hospital Hamburg-Eppendorf, D-20246, Germany., Mori MA; Department of Biophysics, Federal University of Sao Paulo, Brazil., Brüning JC; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, D-50937, Germany.; German Center for Diabetes Research (DZD), Germany., Kornfeld JW; Max Planck Institute for Metabolism Research, D-50931 Cologne, Germany.; Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD), D-50931 Cologne, Germany.

Publikováno v: Nature cell biology [Nat Cell Biol] 2016 Mar; Vol. 18 (3), pp. 328-36. Date of Electronic Publication: 2016 Feb 22.

m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway.

Autor: Lin, Kai^1,2 (AUTHOR), Zhou, Endi² (AUTHOR), Shi, Ting³ (AUTHOR), Zhang, Siqing² (AUTHOR), Zhang, Jinfan² (AUTHOR), Zheng, Ziruo² (AUTHOR), Pan, Yuetian⁴ (AUTHOR), Gao, Wentao² (AUTHOR) seelinc@njmu.edu.cn, Yu, Yabin³ (AUTHOR) yuyabinbin@126.com

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 11/21/2023, Vol. 42 Issue 1, p1-19. 19p.

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Autor: Mauer J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany. [4]., Chaurasia B; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2]., Goldau J; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany., Vogt MC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Ruud J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Nguyen KD; Cardiovascular Research Institute, Departments of Physiology and Medicine, University of California, San Francisco, California, USA., Theurich S; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Hausen AC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Schmitz J; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne, Cologne, Germany., Brönneke HS; 1] Max Planck Institute for Neurological Research, Cologne, Germany. [2] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Estevez E; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Allen TL; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Mesaros A; Max Planck Institute for Biology of Ageing, Cologne, Germany., Partridge L; Max Planck Institute for Biology of Ageing, Cologne, Germany., Febbraio MA; Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Chawla A; Cardiovascular Research Institute, Departments of Physiology and Medicine, University of California, San Francisco, California, USA., Wunderlich FT; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany., Brüning JC; 1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany. [4] Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany. [5] Center for Molecular Medicine Cologne, Cologne, Germany.

Publikováno v: Nature immunology [Nat Immunol] 2014 May; Vol. 15 (5), pp. 423-30. Date of Electronic Publication: 2014 Mar 30.