Výsledky vyhledávání - "Bríd M, Ryan"

Akademický článek

DRD1 suppresses cell proliferation and reduces EGFR activation and PD‐L1 expression in NSCLC

Autor: Christopher E. Grant, Amy L. Flis, Leila Toulabi, Adriana Zingone, Emily Rossi, Krist Aploks, Heather Sheppard, Bríd M. Ryan

Publikováno v: Molecular Oncology, Vol 18, Iss 6, Pp 1631-1648 (2024)

Dopamine (DA) acts in various key neurological and physiological processes as both a neurotransmitter and circulating hormone. Over the past several decades, the DA signaling network has been shown to regulate the progression of several types of soli

Externí odkaz: https://doaj.org/article/14bcc8545fa94d06aaec7e94a26f8d35

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Akademický článek

Automated next-generation profiling of genomic alterations in human cancers

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The genomic profiling of tumours has not been widely adopted in the clinic due to technical and practical hurdles. Here, the authors develop PGDx elio tissue complete, a scalable, standardised and FDA-cleared test comprising a targeted gene panel and

Externí odkaz: https://doaj.org/article/e4aa27119f0a4f1f9ac75c8283f59ea8

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Akademický článek

A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing

Autor: Sanju Sinha, Karina Barbosa, Kuoyuan Cheng, Mark D. M. Leiserson, Prashant Jain, Anagha Deshpande, David M. Wilson, Bríd M. Ryan, Ji Luo, Ze’ev A. Ronai, Joo Sang Lee, Aniruddha J. Deshpande, Eytan Ruppin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may co

Externí odkaz: https://doaj.org/article/5fe16eb955dc4e7db09618e84c592388

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Akademický článek

A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients

Autor: Adriana Zingone, Sanju Sinha, Michael Ante, Cu Nguyen, Dalia Daujotyte, Elise D. Bowman, Neelam Sinha, Khadijah A. Mitchell, Qingrong Chen, Chunhua Yan, Phillipe Loher, Daoud Meerzaman, Eytan Ruppin, Bríd M. Ryan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Alternative polyadenylation (APA) regulates the length of the 3′UTR of mRNA. Here, the authors describe a method to accurately measure APA in tumours and apply this method to investigate the differences in APA in African American and European Ameri

Externí odkaz: https://doaj.org/article/6fd436d5357e43f98a5a57bc9ef4218b

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Akademický článek

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)

The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) is identified as a urinary metabolite associated with risk and prognosis in lung and liver

Externí odkaz: https://doaj.org/article/cade40de76004f3eac0d8228a46781a4

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Akademický článek

Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)

Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently

Externí odkaz: https://doaj.org/article/cad556f170ba4c32bd112c041c7993c8

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Akademický článek

Interaction between the microbiome and TP53 in human lung cancer

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-16 (2018)

Abstract Background Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, reduces epithelial barrier integrity and increases susceptibilit

Externí odkaz: https://doaj.org/article/c60baebde4ef47978781cd73c5e4c2ee

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Data from A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood

Autor: Bríd M. Ryan, Ann G. Schwartz, Bo Deng, Angela S. Wenzlaff, Susan Olivo-Marston, Yi Wang, K. Leigh Greathouse, Kirsi Vähäkangas, Elise D. Bowman, Kara Calhoun, Andrew C. McClary, Jin Jen, Ping Yang, Ana I. Robles

Lung cancer has a familial component which suggests a genetic contribution to its etiology. Given the strong evidence linking smoking with lung cancer, we studied miRNA-related loci in genes associated with smoking behavior. CHRNA, CHRNB gene familie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89fa8f3f8dc1a6b9b80aacc5a107c8fc
https://doi.org/10.1158/1940-6207.c.6544487

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