Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

Autor: Simone Ladeia-Andrade, Rodrigo M. Corder, Marcelo U. Ferreira, Gabriel W. Rangel, Igor Cavallini Johansen, Taís Nóbrega de Sousa, José Pedro Gil

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 9-24 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Emerging antimalarial drug resistance may undermine current efforts to control and eliminate Plasmodium vivax, the most geographically widespread yet neglected human malaria parasite. Endemic countries are expected to assess regularly the therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e5ae265fa9864da475e8994bd43548
http://www.sciencedirect.com/science/article/pii/S221132072030049X

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

Autor: Casper Rokx, Tsung Wai Kan, Tokameh Mahmoudi, Mateusz Stoszko, Elisa De Crignis, Cynthia Lungu, Robert-Jan Palstra, Annelies Verbon, Emily C. Dykhuizen, Charles A. Boucher, Mir M. Khalid

Publikováno v: EBioMedicine, Vol 3, Iss C, Pp 108-121 (2016)
EBioMedicine
EBioMedicine, 3, 108-121. Elsevier

Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e28d0cb1f395267e05515a5705b4c3
https://doi.org/10.1016/j.ebiom.2015.11.047

Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma

Autor: Larisa M. Haupt, Emily T. Camilleri, Rodney A. Lea, Lyn R. Griffiths, Heidi G. Sutherland, Gabrielle Bradshaw

Publikováno v: Meta Gene

The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Polymorphisms of genes in this pathway affect its regulation and have been linked to lymphoma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433215d47696f1c33e815a99db0f7f08
https://doi.org/10.1016/j.mgene.2015.09.004

Association of the chicken MHC B haplotypes with resistance to avian coronavirus

Autor: L.M. Yates, Suzana Tkalcic, Ghida R. Banat, Mark W. Jackwood, Miguel D. Saggese, Ellen W. Collisson, Jennifer Dzielawa, W. E. Briles, Renee Kopulos

Publikováno v: Developmental and Comparative Immunology

Clinical respiratory illness was compared in five homozygous chicken lines, originating from homozygous B2, B8, B12 and B19, and heterozygous B2/B12 birds after infection with either of two strains of the infectious bronchitis virus (IBV). All chicke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c7e9e6bb9c2ddc0185deb8a5933e59
http://europepmc.org/articles/PMC7103219

Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms

Autor: Francesco Salvatore, Gabriella Esposito, Francesca De Falco, Armando Cevenini, Alessandro Cuomo, Fabrizio Pane, Margherita Ruoppolo, Dario Sabbatino

Publikováno v: Biochemical Journal

AF4 belongs to a family of proteins implicated in childhood lymphoblastic leukaemia, FRAXE (Fragile X E site) mental retardation and ataxia. AF4 is a transcriptional activator that is involved in transcriptional elongation. Although AF4 has been impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91901eb92bec35693ec7c608ca9e749f
https://doi.org/10.1042/bj20101633