International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Autor: Caroline M. Nievergelt, Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Shareefa Dalvie, Laramie E. Duncan, Joel Gelernter, Daniel F. Levey, Mark W. Logue, Renato Polimanti, Allison C. Provost, Andrew Ratanatharathorn, Murray B. Stein, Katy Torres, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Søren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegovic, Dragan Babić, Marie Bækvad-Hansen, Dewleen G. Baker, Jean C. Beckham, Laura J. Bierut, Jonathan I. Bisson, Marco P. Boks, Elizabeth A. Bolger, Anders D. Børglum, Bekh Bradley, Megan Brashear, Gerome Breen, Richard A. Bryant, Angela C. Bustamante, Jonas Bybjerg-Grauholm, Joseph R. Calabrese, José M. Caldas- de- Almeida, Anders M. Dale, Mark J. Daly, Nikolaos P. Daskalakis, Jürgen Deckert, Douglas L. Delahanty, Michelle F. Dennis, Seth G. Disner, Katharina Domschke, Alma Dzubur-Kulenovic, Christopher R. Erbes, Alexandra Evans, Lindsay A. Farrer, Norah C. Feeny, Janine D. Flory, David Forbes, Carol E. Franz, Sandro Galea, Melanie E. Garrett, Bizu Gelaye, Elbert Geuze, Charles Gillespie, Aferdita Goci Uka, Scott D. Gordon, Guia Guffanti, Rasha Hammamieh, Supriya Harnal, Michael A. Hauser, Andrew C. Heath, Sian M. J. Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Angela G. Junglen, Karen-Inge Karstoft, Milissa L. Kaufman, Ronald C. Kessler, Alaptagin Khan, Nathan A. Kimbrel, Anthony P. King, Nastassja Koen, Henry R. Kranzler, William S. Kremen, Bruce R. Lawford, Lauren A. M. Lebois, Catrin E. Lewis, Sarah D. Linnstaedt, Adriana Lori, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Jessica Maples-Keller, Charles Marmar, Alicia R. Martin, Nicholas G. Martin, Douglas Maurer, Matig R. Mavissakalian, Alexander McFarlane, Regina E. McGlinchey, Katie A. McLaughlin, Samuel A. McLean, Sarah McLeay, Divya Mehta, William P. Milberg, Mark W. Miller, Rajendra A. Morey, Charles Phillip Morris, Ole Mors, Preben B. Mortensen, Benjamin M. Neale, Elliot C. Nelson, Merete Nordentoft, Sonya B. Norman, Meaghan O’Donnell, Holly K. Orcutt, Matthew S. Panizzon, Edward S. Peters, Alan L. Peterson, Matthew Peverill, Robert H. Pietrzak, Melissa A. Polusny, John P. Rice, Stephan Ripke, Victoria B. Risbrough, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Ken Ruggiero, Ariane Rung, Bart P. F. Rutten, Nancy L. Saccone, Sixto E. Sanchez, Dick Schijven, Soraya Seedat, Antonia V. Seligowski, Julia S. Seng, Christina M. Sheerin, Derrick Silove, Alicia K. Smith, Jordan W. Smoller, Scott R. Sponheim, Dan J. Stein, Jennifer S. Stevens, Jennifer A. Sumner, Martin H. Teicher, Wesley K. Thompson, Edward Trapido, Monica Uddin, Robert J. Ursano, Leigh Luella van den Heuvel, Miranda Van Hooff, Eric Vermetten, Christiaan H. Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Thomas Werge, Michelle A. Williams, Douglas E. Williamson, Sherry Winternitz, Christiane Wolf, Erika J. Wolf, Jonathan D. Wolff, Rachel Yehuda, Ross McD. Young, Keith A. Young, Hongyu Zhao, Lori A. Zoellner, Israel Liberzon, Kerry J. Ressler, Magali Haas, Karestan C. Koenen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals

Externí odkaz: https://doaj.org/article/d39ff05b76b746a5b312681b5db7b9fc

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Autor: Alma Dzubur Kulenovic, Michael J. Lyons, Elizabeth A. Bolger, Kenneth J. Ruggiero, Zhewu Wang, Laramie E. Duncan, Bozo Lugonja, Joanne Voisey, José Miguel Caldas-de-Almeida, Regina E. McGlinchey, Laura J. Bierut, Michael A. Hauser, Jean C. Beckham, Dan J. Stein, Alexander C. McFarlane, Elbert Geuze, Victoria B. Risbrough, Douglas Maurer, Christy A. Denckla, Seth G. Disner, William P. Milberg, Erika J. Wolf, Scott R. Sponheim, Caroline M. Nievergelt, Henry R. Kranzler, Clement C. Zai, Antonia V. Seligowski, Miro Jakovljević, Katharina Domschke, Paul A. Arbisi, Thomas Werge, Vasiliki Michopoulos, Joel Gelernter, Sarah D. Linnstaedt, Nastassja Koen, Sonya B. Norman, Nicholas G. Martin, Janine D. Flory, Meghan M Brashear, Melissa A. Polusny, Nathan A. Kimbrel, Douglas L. Delahanty, Milissa L. Kaufman, Peter Roy-Byrne, Magali Haas, Monica Uddin, Matig R. Mavissakalian, William S. Kremen, Ole A. Andreassen, Marco P. Boks, Matthew S. Panizzon, Christiaan H. Vinkers, Bart P. F. Rutten, Heather Lasseter, Richard A. Shaffer, Aferdita Goci, Jessica L. Maples-Keller, Israel Liberzon, Melanie E. Garrett, Alicia K. Smith, Catrin Lewis, Dewleen G. Baker, Murray B. Stein, Xuejun Qin, Nikolaos P. Daskalakis, Sherry Winternitz, Douglas E. Williamson, Alex O. Rothbaum, David Forbes, Leigh van den Heuvel, Scott D. Gordon, Edward J. Trapido, Marti Jett, Ole Mors, Adam X. Maihofer, Christina M. Sheerin, Lori A. Zoellner, A.C. Bustamante, David M. Hougaard, Alexandra Evans, Chia-Yen Chen, Robert H. Pietrzak, Rachel Yehuda, Allison C. Provost, Matthew Peverill, Aarti Gautam, Bruce R. Lawford, Derrick Silove, Bekh Bradley, Gerome Breen, Charles F. Gillespie, Allison E. Ashley-Koch, Kerry J. Ressler, Christiane Wolf, Renato Polimanti, Jonathan Ian Bisson, Adriana Lori, Lynn M. Almli, Norah C. Feeny, Jonas Bybjerg-Grauholm, Guia Guffanti, Søren Bo Andersen, Anders D. Børglum, Elizabeth Ketema, Andrea L. Roberts, Marie Bμkvad-Hansen, Ross McD. Young, Jürgen Deckert, Jonathan Sebat, Rajendra A. Morey, P. B. Mortensen, Lindsay A. Farrer, Yunpeng Wang, Karestan C. Koenen, Joseph R. Calabrese, Bizu Gelaye, Jurjen J. Luykx, Andrew Ratanatharathorn, Charles P. Morris, S. Bryn Austin, Miranda Van Hooff, Edward S. Peters, Katie A. McLaughlin, Anthony P. King, Jonathan R. I. Coleman, Holly K. Orcutt, Keith A. Young, Samuel A. McLean, Jennifer S. Stevens, Rasha Hammamieh, Robert J. Ursano, Mark W. Miller, Allison E. Aiello, Charles R. Marmar, Esmina Avdibegović, Katy Torres, Elliot C. Nelson, Rany M. Salem, Martin H. Teicher, Rebecca Mellor, Karen-Inge Karstoft, Aliza P. Wingo, Alaptagin Khan, Michelle A. Williams, Dick Schijven, Merete Nordentoft, Ananda B. Amstadter, Shareefa Dalvie, Michelle F. Dennis, Mark J. Daly, Mark W. Logue, Soraya Seedat, Julia S. Seng, Carol E. Franz, Stephan Ripke, Karmel W. Choi, Sandro Galea, Richard A. Bryant, Ian Jones, Anders M. Dale, Wesley K. Thompson, Lauren A.M. Lebois, Sixto E. Sanchez, Ronald C. Kessler, Tanja Jovanovic, Divya Mehta, Jordan W. Smoller, Eric O. Johnson, John P. Rice, Andrew C. Heath, Nancy L. Saccone, Barbara O. Rothbaum, Alan L. Peterson, Meaghan O'Donnell, Sian M. J. Hemmings, Eric Vermetten, Dragan Babić, Hongyu Zhao, Tianying Wu, Christopher R. Erbes, Ariane Rung

Publikováno v: Biological Psychiatry, 91(7), 626-636. Elsevier Science
Maihofer, A X, Choi, K W, Coleman, J R I, Daskalakis, N P, Denckla, C A, Ketema, E, Morey, R A, Polimanti, R, Ratanatharathorn, A, Torres, K, Wingo, A P, Zai, C C, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegović, E, Borglum, A D, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Chen, C-Y, Dale, A M, Dalvie, S, Deckert, J R, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Duncan, L E, Džubur Kulenović, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gautam, A, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, C F, Goçi, A, Gordon, S D, Guffanti, G, Hammamieh, R, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljević, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X-J, Karstoft, K-I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C, Liberzon, I, Linnstaedt, S D, Logue, M W, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J L, Marmar, C, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, Mehta, D, Mellor, R, Michopoulos, V, Milberg, W, Miller, M W, Morris, C P, Mors, O, Mortensen, P B, Nelson, E C, Nordentoft, M, Norman, S B, O'Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K J, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, van Hooff, M, Vermetten, E, Vinkers, C, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Yehuda, R, Young, K A, Young, R M, Zhao, H, Zoellner, L A, Haas, M, Lasseter, H, Provost, A C, Salem, R M, Sebat, J, Shaffer, R A, Wu, T, Ripke, S, Daly, M J, Ressler, K J, Koenen, K C, Stein, M B & Nievergelt, C M 2021, ' Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2021.09.020
Maihofer, A X, Choi, K W, Coleman, J R I, Daskalakis, N P, Denckla, C A, Ketema, E, Morey, R A, Polimanti, R, Ratanatharathorn, A, Torres, K, Wingo, A P, Zai, C C, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegović, E, Borglum, A D, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Chen, C Y, Dale, A M, Dalvie, S, Deckert, J, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Duncan, L E, Džubur Kulenović, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gautam, A, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, C F, Goçi, A, Gordon, S D, Guffanti, G, Hammamieh, R, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljević, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X J, Karstoft, K I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C, Liberzon, I, Linnstaedt, S D, Logue, M W, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J L, Marmar, C, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, Mehta, D, Mellor, R, Michopoulos, V, Milberg, W, Miller, M W, Morris, C P, Mors, O, Mortensen, P B, Nelson, E C, Nordentoft, M, Norman, S B, O'Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K J, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, Van Hooff, M, Vermetten, E, Vinkers, C H, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Yehuda, R, Young, K A, Young, R M D, Zhao, H, Zoellner, L A, Haas, M, Lasseter, H, Provost, A C, Salem, R M, Sebat, J, Shaffer, R A, Wu, T, Ripke, S, Daly, M J, Ressler, K J, Koenen, K C, Stein, M B & Nievergelt, C M 2022, ' Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information ', Biological Psychiatry, vol. 91, no. 7, pp. 626-636 . https://doi.org/10.1016/j.biopsych.2021.09.020
Maihofer, A X, Choi, K W, Coleman, J R I, Daskalakis, N P, Denckla, C A, Ketema, E, Morey, R A, Polimanti, R, Ratanatharathorn, A, Torres, K, Wingo, A P, Zai, C C, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegović, E, Borglum, A D, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Chen, C-Y, Dale, A M, Dalvie, S, Deckert, J, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Duncan, L E, Džubur Kulenović, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gautam, A, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, C F, Goçi, A, Gordon, S D, Guffanti, G, Hammamieh, R, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljević, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X-J, Karstoft, K-I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C, Liberzon, I, Linnstaedt, S D, Logue, M W, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J L, Marmar, C, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, Mehta, D, Mellor, R, Michopoulos, V, Milberg, W, Miller, M W, Morris, C P, Mors, O, Mortensen, P B, Nelson, E C, Nordentoft, M, Norman, S B, O'Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K J, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, Van Hooff, M, Vermetten, E, Vinkers, C, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Yehuda, R, Young, K A, Young, R M, Zhao, H, Zoellner, L A, Haas, M, Lasseter, H, Provost, A C, Salem, R M, Sebat, J, Shaffer, R A, Wu, T, Ripke, S, Daly, M J, Ressler, K J, Koenen, K C, Stein, M B & Nievergelt, C M 2021, ' Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2021.09.020
Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico-UPC
UPC-Institucional
Universidad Peruana de Ciencias Aplicadas
instacron:UPC
Biological Psychiatry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biological Psychiatry. Elsevier USA
Biological Psychiatry, 91(7), 626-636. ELSEVIER SCIENCE INC
Biological psychiatry, vol 91, iss 7

Funding Information: This work was supported by the National Institute of Mental Health / U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH10953

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6907d48cedbb58a832cecbee3b996d
https://hdl.handle.net/10362/129670

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Autor: Magali Haas, Nancy L. Saccone, Barbara O. Rothbaum, Jessica L. Maples-Keller, Aferdita Goci Uka, Soraya Seedat, Marie Bækvad-Hansen, Scott R. Sponheim, Sixto E. Sanchez, Nastassja Koen, Alma Dzubur-Kulenovic, Sonya B. Norman, Douglas Maurer, Julia S. Seng, Matig R. Mavissakalian, Wesley K. Thompson, Douglas L. Delahanty, Daniel F. Levey, Matthew S. Panizzon, Megan Brashear, Lindsay A. Farrer, Kenneth J. Ruggiero, John P. Rice, Robert H. Pietrzak, Lori A. Zoellner, Charles F. Gillespie, Lauren A.M. Lebois, Alaptagin Khan, Robert J. Ursano, Chia-Yen Chen, Yunpeng Wang, Karestan C. Koenen, Dewleen G. Baker, Joseph R. Calabrese, Jurjen J. Luykx, Andrew C. Heath, Shareefa Dalvie, Eric O. Johnson, Laura J. Bierut, Catrin Lewis, Henry R. Kranzler, Sarah McLeay, Caroline M. Nievergelt, Michelle F. Dennis, Miro Jakovljević, Merete Nordentoft, Michael A. Hauser, Alexander C. McFarlane, Mark J. Daly, Mark W. Logue, Ole Mors, Andrea L. Roberts, Adam X. Maihofer, S. Bryn Austin, Bart P. F. Rutten, Christiane Wolf, Erika J. Wolf, Sarah D. Linnstaedt, Janine D. Flory, Melanie E. Garrett, Christina M. Sheerin, Elbert Geuze, Alicia K. Smith, Christiaan H. Vinkers, Divya Mehta, Matthew Peverill, Bruce R. Lawford, Scott D. Gordon, José Miguel Caldas de Almeida, Miranda Van Hooff, Supriya Harnal, Edward S. Peters, Ross McD. Young, Derrick Silove, Jennifer A. Sumner, Gerome Breen, Allison E. Ashley-Koch, Michelle A. Williams, Antonia V. Seligowski, A.C. Bustamante, Dick Schijven, Joel Gelernter, Jordan W. Smoller, Nicholas G. Martin, Ananda B. Amstadter, Anthony P. King, Jonathan R. I. Coleman, Alexandra Evans, Alan L. Peterson, Kerry J. Ressler, Martin H. Teicher, Angela G. Junglen, Regina E. McGlinchey, Jonathan Ian Bisson, Adriana Lori, Karen-Inge Karstoft, Marti Jett, Bekh Bradley, Murray B. Stein, Michael J. Lyons, Nikolaos P. Daskalakis, Anders D. Børglum, Holly K. Orcutt, Sherry Winternitz, Carol E. Franz, Meaghan O'Donnell, Elizabeth A. Bolger, Seth G. Disner, William P. Milberg, Renato Polimanti, David Forbes, Alex O. Rothbaum, Edward J. Trapido, William S. Kremen, David M. Hougaard, Ronald C. Kessler, Dan J. Stein, Sian M. J. Hemmings, Tanja Jovanovic, Jonathan D. Wolff, Allison C. Provost, Stephan Ripke, Rachel Yehuda, Karmel W. Choi, Sandro Galea, Richard A. Bryant, Victoria B. Risbrough, Eric Vermetten, Dragan Babić, Ian Jones, Jürgen Deckert, Anders M. Dale, Rajendra A. Morey, Benjamin M. Neale, Melissa A. Polusny, Norah C. Feeny, Xue Jun Qin, Hongyu Zhao, Mark W. Miller, Guia Guffanti, Allison E. Aiello, Charles R. Marmar, Esmina Avdibegović, Torsten Klengel, Jennifer S. Stevens, Jean C. Beckham, Katharina Domschke, Katy Torres, Elliot C. Nelson, Laramie E. Duncan, Bozo Lugonja, Joanne Voisey, Milissa L. Kaufman, Ole A. Andreassen, Douglas E. Williamson, Paul A. Arbisi, Søren Bo Andersen, Thomas Werge, Monica Uddin, Katie A. McLaughlin, Zhewu Wang, Bizu Gelaye, Andrew Ratanatharathorn, Elizabeth G. Atkinson, Charles P. Morris, Preben Bo Mortensen, Christopher R. Erbes, Lynn M. Almli, Jonas Bybjerg-Grauholm, Alicia R. Martin, Nathan A. Kimbrel, Peter Roy-Byrne, Ariane Rung, Israel Liberzon, Leigh van den Heuvel, Marco P. Boks, Keith A. Young, Samuel A. McLean, Rasha Hammamieh

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, 10:4558. Nature Publishing Group
Nievergelt, C M, Maihofer, A X, Klengel, T, Atkinson, E G, Chen, C Y, Choi, K W, Coleman, J R I, Dalvie, S, Duncan, L E, Gelernter, J, Levey, D F, Logue, M W, Polimanti, R, Provost, A C, Ratanatharathorn, A, Stein, M B, Torres, K, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegovic, E, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Børglum, A D, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Dale, A M, Daly, M J, Daskalakis, N P, Deckert, J, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Dzubur-Kulenovic, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gelaye, B, Geuze, E, Gillespie, C, Uka, A G, Gordon, S D, Guffanti, G, Hammamieh, R, Harnal, S, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljevic, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X J, Junglen, A G, Karstoft, K I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C E, Linnstaedt, S D, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J, Marmar, C, Martin, A R, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, McLeay, S, Mehta, D, Milberg, W P, Miller, M W, Morey, R A, Morris, C P, Mors, O, Mortensen, P B, Neale, B M, Nelson, E C, Nordentoft, M, Norman, S B, O’Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Ripke, S, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Sumner, J A, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, Van Hooff, M, Vermetten, E, Vinkers, C H, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Wolff, J D, Yehuda, R, Young, R M D, Young, K A, Zhao, H, Zoellner, L A, Liberzon, I, Ressler, K J, Haas, M & Koenen, K C 2019, ' International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci ', Nature Communications, vol. 10, no. 1, 4558 . https://doi.org/10.1038/s41467-019-12576-w
Nature Communications
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nievergelt, C M, Maihofer, A X, Klengel, T, Atkinson, E G, Chen, C-Y, Choi, K W, Coleman, J R I, Dalvie, S, Duncan, L E, Gelernter, J, Levey, D F, Logue, M W, Polimanti, R, Provost, A C, Ratanatharathorn, A, Stein, M B, Torres, K, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S R B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegovic, E, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Børglum, A D, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Dale, A M, Daly, M J, Daskalakis, N P, Deckert, J R, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Dzubur-Kulenovic, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gelaye, B, Geuze, E, Gillespie, C, Uka, A G, Gordon, S D, Guffanti, G, Hammamieh, R, Harnal, S, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljevic, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X-J, Junglen, A G, Karstoft, K-I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C E, Linnstaedt, S D, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J, Marmar, C, Martin, A R, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, McLeay, S, Mehta, D, Milberg, W P, Miller, M W, Morey, R A, Morris, C P, Mors, O, Mortensen, P B, Neale, B M, Nelson, E C, Nordentoft, M, Norman, S B, O'Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Ripke, S, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Sumner, J A, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, van Hooff, M, Vermetten, E, Vinkers, C H, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Wolff, J D, Yehuda, R, Young, R M, Young, K A, Zhao, H, Zoellner, L A, Liberzon, I, Ressler, K J, Haas, M & Koenen, K C 2019, ' International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci ', Nature Communications, vol. 10, no. 1, pp. 4558 . https://doi.org/10.1038/s41467-019-12576-w, https://doi.org/10.1038/s41467-019-12576-w
Nature Communications, 10(1). Nature Publishing Group
Nievergelt, C M, Maihofer, A X, Klengel, T, Atkinson, E G, Chen, C-Y, Choi, K W, Coleman, J R I, Dalvie, S, Duncan, L E, Gelernter, J, Levey, D F, Logue, M W, Polimanti, R, Provost, A C, Ratanatharathorn, A, Stein, M B, Torres, K, Aiello, A E, Almli, L M, Amstadter, A B, Andersen, S B, Andreassen, O A, Arbisi, P A, Ashley-Koch, A E, Austin, S B, Avdibegovic, E, Babić, D, Bækvad-Hansen, M, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J I, Boks, M P, Bolger, E A, Børglum, A D, Bradley, B, Brashear, M, Breen, G, Bryant, R A, Bustamante, A C, Bybjerg-Grauholm, J, Calabrese, J R, Caldas-de-Almeida, J M, Dale, A M, Daly, M J, Daskalakis, N P, Deckert, J, Delahanty, D L, Dennis, M F, Disner, S G, Domschke, K, Dzubur-Kulenovic, A, Erbes, C R, Evans, A, Farrer, L A, Feeny, N C, Flory, J D, Forbes, D, Franz, C E, Galea, S, Garrett, M E, Gelaye, B, Geuze, E, Gillespie, C, Uka, A G, Gordon, S D, Guffanti, G, Hammamieh, R, Harnal, S, Hauser, M A, Heath, A C, Hemmings, S M J, Hougaard, D M, Jakovljevic, M, Jett, M, Johnson, E O, Jones, I, Jovanovic, T, Qin, X-J, Junglen, A G, Karstoft, K-I, Kaufman, M L, Kessler, R C, Khan, A, Kimbrel, N A, King, A P, Koen, N, Kranzler, H R, Kremen, W S, Lawford, B R, Lebois, L A M, Lewis, C E, Linnstaedt, S D, Lori, A, Lugonja, B, Luykx, J J, Lyons, M J, Maples-Keller, J, Marmar, C, Martin, A R, Martin, N G, Maurer, D, Mavissakalian, M R, McFarlane, A, McGlinchey, R E, McLaughlin, K A, McLean, S A, McLeay, S, Mehta, D, Milberg, W P, Miller, M W, Morey, R A, Morris, C P, Mors, O, Mortensen, P B, Neale, B M, Nelson, E C, Nordentoft, M, Norman, S B, O’Donnell, M, Orcutt, H K, Panizzon, M S, Peters, E S, Peterson, A L, Peverill, M, Pietrzak, R H, Polusny, M A, Rice, J P, Ripke, S, Risbrough, V B, Roberts, A L, Rothbaum, A O, Rothbaum, B O, Roy-Byrne, P, Ruggiero, K, Rung, A, Rutten, B P F, Saccone, N L, Sanchez, S E, Schijven, D, Seedat, S, Seligowski, A V, Seng, J S, Sheerin, C M, Silove, D, Smith, A K, Smoller, J W, Sponheim, S R, Stein, D J, Stevens, J S, Sumner, J A, Teicher, M H, Thompson, W K, Trapido, E, Uddin, M, Ursano, R J, van den Heuvel, L L, Van Hooff, M, Vermetten, E, Vinkers, C H, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, M A, Williamson, D E, Winternitz, S, Wolf, C, Wolf, E J, Wolff, J D, Yehuda, R, Young, R M, Young, K A, Zhao, H, Zoellner, L A, Liberzon, I, Ressler, K J, Haas, M & Koenen, K C 2019, ' International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci ', Nature Communications, vol. 10, no. 1, 4558 . https://doi.org/10.1038/s41467-019-12576-w
The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups 2019, ' International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci ', Nature Communications, vol. 10, no. 1, pp. 4558 . https://doi.org/10.1038/s41467-019-12576-w

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3d5e0c935fb2e6ba9580e21673dbad
https://doi.org/10.1038/s41467-019-12576-w

A2.16 Synovial Fluid Neutrophils Undergoing Netosis Contribute to Joint Inflammation by Producing Citrullinated Autoantigens

Autor: Paul R. Cooper, Dagmar Scheel-Toellner, Karim Raza, Iain L. C. Chapple, Christopher D. Buckley, Mark J. Pearson, Andrew Filer, Anthony P. Nicholas, Andrew J. Creese, Julia Spengler, Michael R. Milward, Bozo Lugonja

Publikováno v: Annals of the Rheumatic Diseases. 72:A10.1-A10

Objectives Anti-citrullinated protein antibodies (ACPA) are characteristically detected in patients with rheumatoid arthritis (RA) and growing evidence suggests that they are involved in disease pathogenesis. During disease flares large numbers of ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba0391ad0c5c2e35d70b7382fc40ea42
https://doi.org/10.1136/annrheumdis-2013-203215.16