Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Bozidar Purtic"'
Autor:
Christopher J. Gilpin, Christoph Wülfing, Kenneth S. Chen, Nadia Parvaze, Mark M. Davis, Michael D. Sjaastad, Kentner L. Singleton, Kavyya R. Dama, Paula Jennings, Bozidar Purtic
Publikováno v:
The Journal of Immunology. 177:4402-4413
T cell activation is driven by the TCR and complemented by costimulation. We have studied the dynamics of ligand-engagement of the costimulatory receptor CD2 in T cell/APC couples. Thousands of ligand-engaged CD2 molecules were included in a large T
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2904-2909
During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive sear
Autor:
Lisa A, Pitcher, Meredith A, Mathis, Jennifer A, Young, Laura M, DeFord, Bozidar, Purtic, Christoph, Wulfing, Nicolai S C, van Oers
Publikováno v:
European journal of immunology. 35(12)
T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine-based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR zetazeta and CD3 gammaepsilon/deltaepsil
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(13)
Cytolytic killing is a major effector mechanism in the elimination of virally infected and tumor cells. The innate cytolytic effectors, natural killer (NK) cells, and the adaptive effectors, cytotoxic T cells (CTL), despite differential immune recogn