Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bozena, Frackowiak"'
Autor:
Yan Yin, E. Hampton Sessions, Bozena Frackowiak, Claudia Ruiz, Bo Wang, Philip LoGrasso, Thomas Schröter, Jennifer Pocas, Li Lin, Sarwat Chowdhury, Michael D. Cameron, Yen Ting Chen, Yangbo Feng, Michael P. Smolinski, Thomas D. Bannister
Publikováno v:
Bioorganic & Medicinal Chemistry Letters : a tetrahedron publication for the rapid dissemination of preliminary communication and all aspects of bioorganic chemistry, medicinal chemistry and related disciplines. 20(6):1939-1943
Rho Kinase (ROCK) is a serine/threonine kinase whose inhibition could prove beneficial in numerous therapeutic areas. We have developed a promising class of ATP-competitive inhibitors based upon a benzimidazole scaffold, which show excellent potency
Autor:
Yuan Yuan Ling, Weimin Chen, Philip LoGrasso, Youseung Shin, Xinyi Song, Theodore M. Kamenecka, Jeff Habel, Derek R. Duckett, Bozena Frackowiak, Rong Jiang
Publikováno v:
Journal of Biological Chemistry. 284(19):12853-12861
c-Jun N-terminal kinase 3alpha1 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and activating transcription factor-2 (ATF-2) upon ac
Autor:
Stanisław Szala, Hubert Wojtasek, Beata Gasowska-Bajger, Bozena Frackowiak-Wojtasek, Tomasz Cichoń, Ryszard Smolarczyk, Sabina Koj
Publikováno v:
Bioorganic & Medicinal Chemistry Letters : a tetrahedron publication for the rapid dissemination of preliminary communication and all aspects of bioorganic chemistry, medicinal chemistry and related disciplines. 19(13):3507-3510
Oxidation of the anti-Parkinsonian agent carbidopa by tyrosinase was investigated. The products of this reaction were identified as 3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid and 6,7-dihydroxy-3-methylcinnoline. These results demonstrate that aft
Autor:
Evelyn Griffin, Bozena Frackowiak, Michael D. Cameron, Yangbo Feng, Li Lin, Thomas Schröter, Philip LoGrasso, Claudia Ruiz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters : a tetrahedron publication for the rapid dissemination of preliminary communication and all aspects of bioorganic chemistry, medicinal chemistry and related disciplines. 17(8):2355-2360
ROCK has been implicated in many diseases ranging from glaucoma to spinal cord injury and is therefore an important target for therapeutic intervention. In this study, we have designed a series of 1-(4-(1H-indazol-5-yl)piperazin-1-yl)-2-hydroxy(or 2-
Autor:
Monika, Kubacka, Tadeusz, Librowski, Ryszard, Czarnecki, Bozena, Frackowiak, Stanisław, Lochyński
Publikováno v:
Pharmacological Reports. 10:936-943
The present study was designed to investigate the central nervous system activity of terpene GABA (and piracetam) derivatives designated as BF-1, BF-2, BF-3, BF-4, BF-5, BF-6. We assessed their anticonvulsant activity in the two main mouse models of
Publikováno v:
ChemInform. 46
Autor:
Youseung Shin, Theodore M. Kamenecka, Bozena Frackowiak, Rong Jiang, Weimin Chen, Michael D. Cameron, Xinyi Song, Li Lin, Derek R. Duckett
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(9)
Starting from pyrazole HTS hit (1), a series of 1-aryl-1H-indazoles have been synthesized as JNK3 inhibitors with moderate selectivity against JNK1. SAR studies led to the synthesis of 5r as double digital nanomolar JNK3 inhibitor with good in vivo e