Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

Autor: Wandi Du, Jiarong Hu, Jingru Liang, Xiaolei Yang, Boyu Fang, Guo Ma

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Objective: This study aimed to investigate effect of antidiabetic herb Astragali Radix (AR) on pharmacokinetic behavior of dapagliflozin (DAPA) in healthy rats and type 2 diabetes mellitus (T2DM) rats.Methods: The T2DM rats were induced by high-fat d

Externí odkaz: https://doaj.org/article/7befd112a7e34cf0ae891dc1913d0519

Simultaneous Characterization and Determination of Warfarin and Its Hydroxylation Metabolites in Rat Plasma by Chiral Liquid Chromatography-Tandem Mass Spectrometry

Autor: Shasha Jin, Zhihong Li, Qing Yang, Boyu Fang, Xiaoqiang Xiang, Chao Peng, Weimin Cai

Publikováno v: Pharmaceutics, Vol 14, Iss 6, p 1141 (2022)

Warfarin is extensively used for venous thromboembolism and other coagulopathies. In clinical settings, warfarin is administered as a mixture of S- and R-warfarin, and both enantiomers are metabolized by multiple cytochrome P450 enzymes into many hyd

Externí odkaz: https://doaj.org/article/538b014b43444bb18b1472b4fba1c059

A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme

Autor: Xiaoqiang Xiang, Yawen Yuan, Guo Ma, Weimin Cai, Shunguo Zhang, Boyu Fang, Bin Zhu, Jun Zhang

Publikováno v: Pharmaceutics
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1734, p 1734 (2021)

In order to improve the benefit–risk ratio of pharmacokinetic (PK) research in the early development of new drugs, in silico and in vitro methods were constructed and improved. Models of intrinsic clearance rate (CLint) were constructed based on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3ef9a23e17ce62ed71a2ce21dfc9b3
https://doi.org/10.3390/pharmaceutics13101734

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking.

Autor: Li J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Huang Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Lu S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Luo H; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China., Tan Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Ye P; Chinese Medicine Department of the Cancer Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Liu X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Wu Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Wu C; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Stalin A; State Key Laboratory of Subtropical Silviculture, Department of Traditional Chinese Medicine, Zhejiang A&F University, Hangzhou, China., Wang H; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Liu Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Shen L; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Fan X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Zhang B; Beijing Zhongyan Tong Ren Tang Pharmaceutical R&d Co. LTD, Beijing, China., Yi J; Beijing Zhongyan Tong Ren Tang Pharmaceutical R&d Co. LTD, Beijing, China., Yao L; Beijing Zhongyan Tong Ren Tang Pharmaceutical R&d Co. LTD, Beijing, China., Xu Y; Beijing Zhongyan Tong Ren Tang Pharmaceutical R&d Co. LTD, Beijing, China., Wu J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Duan X; Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117, Meishan Road, Shushan District, Hefei City, Anhui Province, PR China.

Publikováno v: Medicine [Medicine (Baltimore)] 2021 Dec 23; Vol. 100 (51), pp. e27112.

Dictionary of the Ben Cao Gang Mu, Volume 3 : Persons and Literary Sources

Autor: Zheng Jinsheng, Nalini Kirk, Paul D. Buell

The Ben cao gang mu, compiled in the second half of the sixteenth century by a team led by the physician Li Shizhen (1518–1593) on the basis of previously published books and contemporary knowledge, is the largest encyclopedia of natural history in