Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Boylan John Frederick"'
Autor:
Huisheng Wang, Christine Rizzo, Neal Rosen, Brian Higgins, Huifeng Niu, Sherif Daouti, Yang Wen, Wen-hui Li, David C. Heimbrook, Packman Kathryn E, Boylan John Frederick
Publikováno v:
Cancer Research. 71:5535-5545
Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655f034c22fb537391ef3b8d1bd645e7
https://doi.org/10.1158/0008-5472.can-10-4351
https://doi.org/10.1158/0008-5472.can-10-4351
Autor:
Bidyut Roy, Philippe Bouillet, Reshma Taneja, Pierre Chambon, Boylan John Frederick, Lorraine J. Gudas, Marie-Pierre Gaub
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7854-7858
Disruption of retinoic acid receptor (RAR) gamma in F9 embryonal carcinoma cells leads to aberrent differentiation and reduced activation of expression of several all-trans-retinoic acid (RA)-induced genes. We have analyzed the expression of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674a070e0edcb1ff6f42e022d0aa0d8c
https://doi.org/10.1073/pnas.92.17.7854
https://doi.org/10.1073/pnas.92.17.7854
Publikováno v:
Molecular and Cellular Biology. 15:843-851
F9 embryonic teratocarcinoma stem cells differentiate into an epithelial cell type called extraembryonic endoderm when treated with retinoic acid (RA), a derivative of retinol (vitamin A). This differentiation is presumably mediated through the actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe209f55b310a55fe2255f2e97f22055
https://doi.org/10.1128/mcb.15.2.843
https://doi.org/10.1128/mcb.15.2.843
Autor:
Brian P. Higgins, Christine Tardell, Brenden Chen, Boylan John Frederick, Packman Kathryn E, Huifeng Niu
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42598 (2012)
PLoS ONE
PLoS ONE
Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84df8eb35f6858cd60991b58694c083
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880048/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880048/?tool=EBI
Publikováno v:
Proceedings of the National Academy of Sciences. 90:9601-9605
Retinoic acid (RA) signal transduction is believed to be mediated through several high-affinity nuclear receptors [RA receptors (RARs) and retinoid X receptors], which are members of the steroid/thyroid/vitamin D superfamily and function as transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdc58183be4382a3b0e5111977ef2d3
https://doi.org/10.1073/pnas.90.20.9601
https://doi.org/10.1073/pnas.90.20.9601
Publikováno v:
Journal of Biological Chemistry. 267:21486-21491
The CRABP-I and CRABP-II proteins are high affinity cytoplasmic retinoic acid-binding proteins. In undifferentiated F9 teratocarcinoma stem cells, only the CRABP-I protein is expressed at detectable levels. We have previously shown that overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8b4afc500645bfda7ed072dac17d29
https://doi.org/10.1016/s0021-9258(19)36635-9
https://doi.org/10.1016/s0021-9258(19)36635-9
Autor:
Helmut Jacobsen, James Cai, Boylan John Frederick, Wei He, Michael Linn, Leopoldo Luistro, Holly Hilton, Melissa Smith, Maria Vilenchik, Roland Jakob-Røtne, David C. Heimbrook, Kelli Glenn, John D. Roberts, Packman Kathryn E, Daisy Carvajal, Windy Berkofsky-Fessler, Alexander Flohr
Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of γ-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e705b4a8e77cd61d65bca0e9101d61
https://europepmc.org/articles/PMC5260798/
https://europepmc.org/articles/PMC5260798/
Autor:
Marcus Fechheimer, Sandra Parker, Jesse E. Sisken, Stephen G. Zimmer, Boylan John Frederick, Gordhan L. Patel
Publikováno v:
Proceedings of the National Academy of Sciences. 84:8463-8467
Scrape loading and sonication loading are two recently described methods of introducing macromolecules into living cells. We have tested the efficacy of these methods for transfection of mammalian cells with exogenous DNA, using selection systems bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd12f393cb1ed1711d215843b74ba4e5
https://doi.org/10.1073/pnas.84.23.8463
https://doi.org/10.1073/pnas.84.23.8463