Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Boye S. Nielsen"'
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Data from Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer
Autor: Thomas Reinheckel, Christoph Peters, Matthew Bogyo, Kasper Almholt, Boye S. Nielsen, Nicole Augustin, Jan Deussing, Matvey Korovin, Harald Brodoefel, Achim Krüger, Anna Papazoglou, Olga Vasiljeva
Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis. We show here that mouse mammary tumor virus–polyoma middle T antigen (PyMT) transgenic mice deficient for the cysteine protease cathepsin B (CTSB) exhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07674c625ffb90c7598ee73920fd99ce
https://doi.org/10.1158/0008-5472.c.6494225
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4
MUCOSAL EXPRESSION OF GENES PI3, ANXA1, AND VDR DESCRIMINATES CROHNS DISEASE FROM ULCERATIVE COLITIS IN INFLAMMATORY BOWEL DISEASE PATIENTS
Autor: Jaslin James, Boye S Nielsen, Ib Christensen, Ebbe Langholz, Mikkel Malham, Lene Riis, Estrid Høgdall
Publikováno v: Gastroenterology. 164:S17
INTRODUCTION Differential diagnosis of Inflammatory Bowel Disease Unclassified (IBDU) patients to Crohn’s Disease (CD) or Ulcerative Colitis (UC) at diagnosis is challenging. Personalized disease-specific strategies are becoming state of art and th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cb08ea785826e2f915edbd6f10f69f
https://doi.org/10.1053/j.gastro.2023.03.041
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5
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells
Autor: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen
Publikováno v: Duwe, L, Munoz-Garrido, P, Lewinska, M, Lafuente-Barquero, J, Satriano, L, Høgdall, D, Taranta, A, Nielsen, B S, Ghazal, A, Matter, M S, Banales, J M, Aldana, B I, Gao, Y-T, Marquardt, J U, Roberts, L R, Oliveira, R C, Koshiol, J, O'Rourke, C J & Andersen, J B 2022, ' MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells ', Journal of Hepatology, vol. 78 . https://doi.org/10.1016/j.jhep.2022.10.012
Journal of Hepatology
Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e66c0650516d2ceadf1aaae8cfc9a5
https://curis.ku.dk/portal/da/publications/microrna27a3p-targets-foxo-signalling-to-induce-tumourlike-phenotypes-in-bile-duct-cells(e2e06416-2bd3-4e90-9573-ab895519c481).html
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6
Akademický článek
Tissue microRNAs as predictors of outcome in patients with metastatic colorectal cancer treated with first line Capecitabine and Oxaliplatin with or without Bevacizumab.
Autor: Mogens K Boisen, Christian Dehlendorff, Dorte Linnemann, Boye S Nielsen, Jim S Larsen, Kell Osterlind, Svend E Nielsen, Line S Tarpgaard, Camilla Qvortrup, Per Pfeiffer, Niels H Holländer, Nina Keldsen, Torben F Hansen, Brita B Jensen, Estrid V S Høgdall, Benny V Jensen, Julia S Johansen
Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109430 (2014)
PURPOSE: We tested the hypothesis that expression of microRNAs (miRNAs) in cancer tissue can predict effectiveness of bevacizumab added to capecitabine and oxaliplatin (CAPEOX) in patients with metastatic colorectal cancer (mCRC). EXPERIMENTAL DESIGN
Externí odkaz: https://doaj.org/article/6cd8372b3db94d9ebca0c391d81dd6a1
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7
Akademický článek
Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.
Autor: Annika Jögi, Birgitte Rønø, Ida K Lund, Boye S Nielsen, Michael Ploug, Gunilla Høyer-Hansen, John Rømer, Leif R Lund
Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12746 (2010)
BACKGROUND: Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminoge
Externí odkaz: https://doaj.org/article/89e01d982463419fb77fc773fd45e81b
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8
Akademický článek
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Autor: Boye S Nielsen, Mikala Egeblad, Fritz Rank, Hanne A Askautrud, Caroline J Pennington, Tanja X Pedersen, Ib J Christensen, Dylan R Edwards, Zena Werb, Leif R Lund
Publikováno v: PLoS ONE, Vol 3, Iss 8, p e2959 (2008)
Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma, suggesting that it is involved in tumor progression. Durin
Externí odkaz: https://doaj.org/article/deea948b4a904eca8264f2f02979894f
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9
Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice
Autor: Kasper, Almholt, Leif R, Lund, Jørgen, Rygaard, Boye S, Nielsen, Keld, Danø, John, Rømer, Morten, Johnsen
Publikováno v: International journal of cancer. 113(4)
A prominent phenotype of plasmin deficiency in mice is reduced metastasis in the MMTV-PymT transgenic breast cancer model. Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26fa5de6059ceabc90a3fddcca3f8f0c
https://pubmed.ncbi.nlm.nih.gov/15472905
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