CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection.

Autor: Giuliano CJ; Whitehead Institute, Cambridge, MA, USA.; Biology Department, MIT, Cambridge, MA, USA., Wei KJ; Whitehead Institute, Cambridge, MA, USA.; Biology Department, MIT, Cambridge, MA, USA., Harling FM; Whitehead Institute, Cambridge, MA, USA., Waldman BS; Whitehead Institute, Cambridge, MA, USA.; Biology Department, MIT, Cambridge, MA, USA., Farringer MA; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Biological Sciences in Public Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Boydston EA; Whitehead Institute, Cambridge, MA, USA., Lan TCT; Whitehead Institute, Cambridge, MA, USA., Thomas RW; Whitehead Institute, Cambridge, MA, USA.; Biology Department, MIT, Cambridge, MA, USA., Herneisen AL; Whitehead Institute, Cambridge, MA, USA.; Biology Department, MIT, Cambridge, MA, USA., Sanderlin AG; Biology Department, MIT, Cambridge, MA, USA., Coppens I; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Dvorin JD; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lourido S; Whitehead Institute, Cambridge, MA, USA. lourido@wi.mit.edu.; Biology Department, MIT, Cambridge, MA, USA. lourido@wi.mit.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Sep; Vol. 9 (9), pp. 2323-2343. Date of Electronic Publication: 2024 Jul 08.

Peroxisome function relies on organelle-associated mRNA translation.

Autor: Dahan N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Bykov YS; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Boydston EA; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, California Institute for Quantitative Biosciences, Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA., Fadel A; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Gazi Z; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Hochberg-Laufer H; The Mina and Everard Goodman Faculty of Life Sciences, The Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat Gan 5290002, Israel., Martenson J; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA., Denic V; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA., Shav-Tal Y; The Mina and Everard Goodman Faculty of Life Sciences, The Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat Gan 5290002, Israel., Weissman JS; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, California Institute for Quantitative Biosciences, Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA., Aviram N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Zalckvar E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Schuldiner M; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.

Publikováno v: Science advances [Sci Adv] 2022 Jan 14; Vol. 8 (2), pp. eabk2141. Date of Electronic Publication: 2022 Jan 12.

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.

Autor: Miller-Vedam LE; Molecular, Cellular, and Computational Biophysics Graduate Program, University of California, San Francisco, San Francisco, United States.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.; Department of Biology, Whitehead Institute, MIT, Cambridge, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Bräuning B; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany., Popova KD; Department of Biology, Whitehead Institute, MIT, Cambridge, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, United States., Schirle Oakdale NT; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Bonnar JL; Department of Biology, Whitehead Institute, MIT, Cambridge, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Prabu JR; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany., Boydston EA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Sevillano N; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Shurtleff MJ; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Stroud RM; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States., Craik CS; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Schulman BA; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany., Frost A; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States., Weissman JS; Department of Biology, Whitehead Institute, MIT, Cambridge, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Howard Hughes Medical Institute, Chevy Chase, United States.

Publikováno v: ELife [Elife] 2020 Nov 25; Vol. 9. Date of Electronic Publication: 2020 Nov 25.

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells.

Autor: Ray GJ; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA., Boydston EA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Shortt E; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Wyant GA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA., Lourido S; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chen WW; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: walter.chen@childrens.harvard.edu., Sabatini DM; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: sabatini@wi.mit.edu.

Publikováno v: IScience [iScience] 2020 May 22; Vol. 23 (5), pp. 101109. Date of Electronic Publication: 2020 Apr 28.

A model for sealing plasmalemmal damage in neurons and other eukaryotic cells.

Autor: Spaeth CS; Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA., Boydston EA, Figard LR, Zuzek A, Bittner GD

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2010 Nov 24; Vol. 30 (47), pp. 15790-800.