Solitary Kidney Seeks Potassium Alkali to Lower the Pressure.

Autor: Boyd-Shiwarski CR; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Rodan AR; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, Utah.; Molecular Medicine Program, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, Utah.; Department of Human Genetics, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, Utah.; Medical Service, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2024 Oct 01; Vol. 35 (10), pp. 1300-1302. Date of Electronic Publication: 2024 Aug 21.

Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury.

Autor: Youm EB; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA., Shipman KE; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Albalawy WN; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA., Vandevender AM; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Sipula IJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Rbaibi Y; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Marciszyn AE; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Lashway JA; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Brown EE; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Bondi CB; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Boyd-Shiwarski CR; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Tan RJ; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Jurczak MJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Weisz OA; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Publikováno v: Function (Oxford, England) [Function (Oxf)] 2024 Jul 11; Vol. 5 (4).

WNK kinases sense molecular crowding and rescue cell volume via phase separation.

Autor: Boyd-Shiwarski CR; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Shiwarski DJ; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Griffiths SE; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Beacham RT; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Norrell L; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84132, USA., Morrison DE; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84132, USA., Wang J; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Mann J; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Tennant W; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Anderson EN; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Franks J; Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Calderon M; Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Connolly KA; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Cheema MU; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Weaver CJ; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Nkashama LJ; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Weckerly CC; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Querry KE; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Pandey UB; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Donnelly CJ; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Sun D; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA., Rodan AR; Department of Human Genetics, University of Utah, Salt Lake City, UT 84132, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84132, USA; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT 84132, USA; Medical Service, VA Salt Lake City Health Care System, Salt Lake City, UT 84148, USA., Subramanya AR; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. Electronic address: ars129@pitt.edu.

Publikováno v: Cell [Cell] 2022 Nov 23; Vol. 185 (24), pp. 4488-4506.e20. Date of Electronic Publication: 2022 Oct 31.

Effects of extreme potassium stress on blood pressure and renal tubular sodium transport.

Autor: Boyd-Shiwarski CR; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Weaver CJ; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Beacham RT; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Shiwarski DJ; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania., Connolly KA; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Nkashama LJ; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Mutchler SM; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Griffiths SE; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Knoell SA; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Sebastiani RS; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Ray EC; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Marciszyn AL; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Subramanya AR; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Veterans Administration, Pittsburgh Healthcare System, Pittsburgh Pennsylvania.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Jun 01; Vol. 318 (6), pp. F1341-F1356. Date of Electronic Publication: 2020 Apr 13.

Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent.

Autor: Boyd-Shiwarski CR; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Shiwarski DJ; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213., Roy A; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Namboodiri HN; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Nkashama LJ; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Xie J; Department of Internal Medicine, Division of Nephrology, University of Iowa Carver College of Medicine, Iowa City, IA 52242., McClain KL; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Marciszyn A; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Kleyman TR; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Tan RJ; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Stolz DB; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Puthenveedu MA; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213., Huang CL; Department of Internal Medicine, Division of Nephrology, University of Iowa Carver College of Medicine, Iowa City, IA 52242., Subramanya AR; Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 ars129@pitt.edu.; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2018 Feb 15; Vol. 29 (4), pp. 499-509. Date of Electronic Publication: 2017 Dec 13.