Microbial and hydrothermal aspects of ferric oxyhydroxides and ferrosic hydroxides: the example of Franklin Seamount, Western Woodlark Basin, Papua New Guinea

Autor: Boyd TD, Scott SD

Publikováno v: Geochemical Transactions, Vol 2, Iss 1, p 45 (2001)

Deposits of Fe-Si-Mn oxyhydroxides are commonly found on the seafloor on seamounts and mid-ocean spreading centers. At Franklin Seamount located near the western extremity of Woodlark Basin, Papua New Guinea, Fe-Si-Mn oxyhydroxides are being precipit

Externí odkaz: https://doaj.org/article/81f182c8560044868ed66dc7901a0de8

Neuron loss in the brain starts in childhood, increases exponentially with age and is halted by GM-CSF treatment in Alzheimer's disease.

Autor: Sillau SH, Coughlan C, Ahmed MM, Nair K, Araya P, Galbraith MD, Bettcher BM, Espinosa JM, Chial HJ, Epperson N, Boyd TD, Potter H

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.

The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice.

Autor: Ahmed MM; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Wang AC; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Elos M; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Chial HJ; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Sillau S; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA., Solano DA; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Coughlan C; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Aghili L; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Anton P; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Markham N; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Adame V; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Gardiner KJ; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Boyd TD; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA., Potter H; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Alzheimer's and Cognition Center, Aurora, CO 80045, USA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: Huntington.Potter@cuanschutz.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2022 Jun 15; Vol. 168, pp. 105694. Date of Electronic Publication: 2022 Mar 18.

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Autor: Ahmed MM; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Johnson NR; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Boyd TD; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Partner Therapeutics, Inc., Lexington, MA, United States., Coughlan C; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Chial HJ; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Potter H; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; University of Colorado Alzheimer's and Cognition Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2021 Sep 16; Vol. 13, pp. 718426. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).

Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease.

Autor: Potter H; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., Woodcock JH; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA., Boyd TD; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., Coughlan CM; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., O'Shaughnessy JR; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA., Borges MT; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; Department of Radiology University of Colorado School of Medicine Aurora Colorado USA., Thaker AA; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; Department of Radiology University of Colorado School of Medicine Aurora Colorado USA., Raj BA; University of South Florida School of Medicine Tampa Florida USA., Adamszuk K; Bioclinica Newark California USA., Scott D; Bioclinica Newark California USA., Adame V; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., Anton P; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., Chial HJ; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.; Linda Crnic Institute for Down Syndrome University of Colorado School of Medicine Aurora Colorado USA., Gray H; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA., Daniels J; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA., Stocker ME; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA., Sillau SH; Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.; University of Colorado Alzheimer's and Cognition Center Aurora Colorado USA.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2021 Mar 24; Vol. 7 (1), pp. e12158. Date of Electronic Publication: 2021 Mar 24 (Print Publication: 2021).