Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Boyd Kenkhuis"'
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Autor:
Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij, Maarten E. Witte, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Blood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit neuroinflammation pre
Externí odkaz:
https://doaj.org/article/20142c75d08c47bfb64eb7ea8bb2e9c3
Autor:
Boyd Kenkhuis, Antonios Somarakis, Lynn R.T. Kleindouwel, Willeke M.C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Publikováno v:
Neurobiology of Disease, Vol 167, Iss , Pp 105684- (2022)
Microglia have been identified as key players in Alzheimer's disease pathogenesis, and other neurodegenerative diseases. Iba1, and more specifically TMEM119 and P2RY12 are gaining ground as presumedly more specific microglia markers, but comprehensiv
Externí odkaz:
https://doaj.org/article/09aedfb13b844e219310394d2add8c36
Autor:
Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and ar
Externí odkaz:
https://doaj.org/article/3f4646cb0a074c658337fbd49da6c5aa
Autor:
Marjolein Bulk, Thijs van Harten, Boyd Kenkhuis, Francesca Inglese, Ingrid Hegeman, Sjoerd van Duinen, Ece Ercan, César Magro-Checa, Jelle Goeman, Christian Mawrin, Mark van Buchem, Gerda Steup-Beekman, Tom Huizinga, Louise van der Weerd, Itamar Ronen
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102637- (2021)
Systemic lupus erythematosus (SLE) is an auto-immune disease characterized by multi-organ involvement. Although uncommon, central nervous system involvement in SLE, termed neuropsychiatric SLE (NPSLE), is not an exception. Current knowledge on underl
Externí odkaz:
https://doaj.org/article/edb4e8dd56f34947a3b94cfe09fee50c
Autor:
Poulomi Banerjee, Evdokia Paza, Emma M. Perkins, Owen G. James, Boyd Kenkhuis, Amy F. Lloyd, Karen Burr, David Story, Dilmurat Yusuf, Xin He, Rolf Backofen, Owen Dando, Siddharthan Chandran, Josef Priller
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102046- (2020)
Microglia are resident tissue macrophages of the central nervous system (CNS) that arise from erythromyeloid progenitors during embryonic development. They play essential roles in CNS development, homeostasis and response to disease. Since microglia
Externí odkaz:
https://doaj.org/article/75a1c32453264622874ece5ccb8fa4a8
Autor:
Marjolein Bulk, Ingrid Hegeman-Kleinn, Boyd Kenkhuis, Ernst Suidgeest, Willeke van Roon-Mom, Jan Lewerenz, Sjoerd van Duinen, Itamar Ronen, Louise van der Weerd
Publikováno v:
NeuroImage: Clinical, Vol 28, Iss , Pp 102498- (2020)
Previous MRI studies consistently reported iron accumulation within the striatum of patients with Huntington’s disease (HD). However, the pattern and origin of iron accumulation is poorly understood. This study aimed to characterize the histopathol
Externí odkaz:
https://doaj.org/article/16f59392ae9d4403a65794b77d7eafb2
Autor:
Boyd Kenkhuis, Laura E. Jonkman, Marjolein Bulk, Mathijs Buijs, Baayla D.C. Boon, Femke H. Bouwman, Jeroen J.G. Geurts, Wilma D.J. van de Berg, Louise van der Weerd
Publikováno v:
NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)
Using 7T T2⁎-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes
Externí odkaz:
https://doaj.org/article/4a5e607594284ccaac224386d7726c4d
Publikováno v:
Trends in Neurosciences. 46:333-335
Autor:
Lucia A. A. Giannini, Marjolein Bulk, Boyd Kenkhuis, Ana Rajicic, Shamiram Melhem, Ingrid Hegeman‐Kleinn, Lucia Bossoni, Ernst Suidgeest, Elise G. P. Dopper, John C. van Swieten, Louise van der Weerd, Harro Seelaar
Publikováno v:
Brain Pathology. Wiley-Blackwell
Neuroinflammation has been implicated in frontotemporal lobar degeneration (FTLD) pathophysiology, including in genetic forms with microtubule-associated protein tau (MAPT) mutations (FTLD-MAPT) or chromosome 9 open reading frame 72 (C9orf72) repeat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1019fa9a095705c9a85660782def34f
https://pure.eur.nl/en/publications/d9caff50-257b-414e-b958-6d46cecb481a
https://pure.eur.nl/en/publications/d9caff50-257b-414e-b958-6d46cecb481a
Autor:
Sunniva M. K. Bøstrand, Luise A. Seeker, Nina-Lydia Kazakou, Nadine Bestard-Cuche, Sarah Jäkel, Boyd Kenkhuis, Neil C. Henderson, Susanne T. de Bot, Willeke van Roon-Mom, Josef Priller, Anna Williams
Huntington’s disease (HD) is a severely debilitating, autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia in the pathology of HD, and we investigated this by conducting singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a71acf0453d36ad57d4ae15be1cb66
https://doi.org/10.1101/2022.09.10.507291
https://doi.org/10.1101/2022.09.10.507291