Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Boyd D. Obermeyer"'
Autor:
Richard F. Bergstrom, Mary Pat Knadler, Alan Rubin, Boyd D Obermeyer, John T. Callaghan, Alan Golichowski
Publikováno v:
Clinical pharmacology and therapeutics. 47(6)
Disposition of the H2-receptor antagonist nizatidine was studied in serum, urine, and breast milk. Five lactating women and five nonlactating women participated; the disposition of nizatidine was studied in three of the lactating women. Single and mu
Publikováno v:
Clinical pharmacology and therapeutics. 47(4)
Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was
Publikováno v:
Journal of Infectious Diseases. 153:1069-1074
The 1-methyl-1 H-tetrazole-5-thiol (MTT) side chain present on several new cephalosporins may be an important factor in coagulopathy observed during therapy with these antibiotics. To determine the plasma kinetics and protein binding of the side chai
Publikováno v:
Clinical Pharmacology and Therapeutics. 37:162-165
The effectiveness of intravenous nizatidine in suppressing gastric acid secretion was evaluated by different methods of inducing secretion in two single-blind studies. In study 1, seven subjects were given single, 20-min intravenous infusions of niza
Autor:
Jeffrey J. Zuravleff, Victor L. Yu, Warren F. Diven, Boyd D. Obermeyer, Robert L. Wolen, James Lyon
Publikováno v:
Therapeutic Drug Monitoring. 3:291-296
Summary We describe a sensitive high pressure liquid chromatographic (HPLC) procedure for the analysis of the new β-lactam antibiotic moxalactam. Conditions are described for either measurement of total drug concentration or the concentration of the
Autor:
Henry R. Black, Edgar A. Ziege, Karen S. Israel, James D. Wolny, Boyd D. Obermeyer, Robert L. Wolen, Gordon L. Brier
Cinoxacin was almost completely absorbed when given orally and was found to be approximately 60 to 70% protein bound. Peak serum concentrations were reached within 2 h, and detectable serum concentrations persisted up to 12 h after administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae84e84a217cbe93f83bf18669d22998
https://europepmc.org/articles/PMC352627/
https://europepmc.org/articles/PMC352627/
Autor:
Howard Rowe, Louis Lemberger, Ross E. Crabtree, Patricia Warrick, Hugh Sullivan, Alan Rubin, Boyd D. Obermeyer
Publikováno v:
Clinical pharmacology and therapeutics. 22(1)
Nabilone is a cannabinoid that is being evaluated in man as a potentially useful psychoactive drug. We found that nabilone was readily absorbed from the human gastrointestinal tract when administered orally as a coprecipitate with polyvinyl-pyrrolido
Publikováno v:
Clinical pharmacology and therapeutics. 42(5)
The absolute and relative bioavailability of nizatidine, an H2-blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% +/- 14%. The bioavailability of single and m