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of 3
pro vyhledávání: '"Boyd Conklin"'
Autor:
Henri Sasmor, Boyd Conklin, Richard S. Geary, Ryan Morgan, Loanne Truong, Cathie York-Defalco, Oleg Khatsenko
Publikováno v:
Antisense and Nucleic Acid Drug Development. 10:35-44
An in situ single-pass perfusion model was used to assess the effect of chemical modification and length on permeability and absorption of various oligonucleotides in rat intestine. Phosphorothioate oligodeoxynucleotides (PS-ODN) were compared with o
Autor:
Gopal B. Inamati, Bruce S. Ross, Muthiah Manoharan, Kathleen L. Tivel, P. Dan Cook, Boyd Conklin
Publikováno v:
Nucleosides and Nucleotides. 16:1141-1143
Recently our laboratory introduced1 chemistries to synthesize 2′- and 3′- cholesteroluridine conjugates which were incorporated into several antisense oligonucleotides. We have now extended this chemistry to other nucleosides (adenosine and cytos
Autor:
R F Azad, Boyd Conklin, Ronnie C. Hanecak, M C Fox, Vickie L. Brown-Driver, Hong Zhang, Kevin P. Anderson
Publikováno v:
Antimicrobial agents and chemotherapy. 43(2)
Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used