Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Boyd A. Howell"'
Publikováno v:
Journal of Biochemical Toxicology. 6:19-27
Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase. It has been previously shown in concanavalin A (con A)-stimulated gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6610e7762b5d8bc8a3ca8fab023980d9
https://doi.org/10.1002/jbt.2570060104
https://doi.org/10.1002/jbt.2570060104
Autor:
Tom R. Norton, Boyd A. Howell, Gary W. Woulfe, Michael W. Duffel, David P. Ringer, Stanley D. Kosanke
Publikováno v:
Molecular carcinogenesis. 9(1)
Enzymatic and immunohistochemical experiments were conducted to evaluate the mechanistic basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2-acetylaminofluorene (2AAF)-induced hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ea9a5a74aba712cd45269e4b82c814
https://pubmed.ncbi.nlm.nih.gov/8297481
https://pubmed.ncbi.nlm.nih.gov/8297481
Publikováno v:
Biochemistry. 24:7498-7502
Purified DNA from the liver of rats, mice, rabbits, and guinea pigs, from guinea pig lymph nodes, from hyperplastic nodules induced in rat liver by feeding with 2-(acetylamino)fluorene, and from Escherichia coli cells was made apurinic by reaction wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab979f0b3367775d4aea4723555f554
https://doi.org/10.1021/bi00346a069
https://doi.org/10.1021/bi00346a069
Autor:
Donald E. Kizer, Boyd A. Howell
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 561:276-293
The onset of stimulated DNA synthesis in regenerating rat liver was studied by pulsing either [Me-3H]thymidine (dThd) or 32Pi into rats at various intervals post-partial hepatectomy. Controls were rats subjected to laparotomy. After isolating DNA by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba29a0852215cebfccdc8a08b962d5c
https://doi.org/10.1016/0005-2787(79)90137-0
https://doi.org/10.1016/0005-2787(79)90137-0
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 740:402-409
The distribution of radioactivity among pyrimidine isostichs (or isoplyths) of DNA from 24-h regenerating rat liver was studied with [3H]Thd, [14C]orotate or with inorganic 32Pi. Expression of incorporated radioactivity as log10% of total radioactivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992f30c6e7087b33755158cef9611016
https://doi.org/10.1016/0167-4781(83)90088-x
https://doi.org/10.1016/0167-4781(83)90088-x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 697:353-362
We tested, in rat liver, the postulate that free polysomes were precursors of membrane-bound polysomes. Three methods were used to isolate free and membrane-bound ribosomes from either post-nuclear or post-mitochondrial supernatants of rat liver. Iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1db2726a7fb73c375d3ec56bb27c9e
https://doi.org/10.1016/0167-4781(82)90099-9
https://doi.org/10.1016/0167-4781(82)90099-9
Publikováno v:
FEBS Letters. 224:59-64
The organization of specific pyrimidine pathways to channel various nucleoside precursors into DNA is poorly understood. We show that concanavalin A-stimulated guinea pig lymphocytes incorporate [3H]dThd, [3H]dCyd, [3H]dUrd, [3H]Cyd and [3H]Urd into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3a49c84250a558467346c5ad956384
https://doi.org/10.1016/0014-5793(87)80422-2
https://doi.org/10.1016/0014-5793(87)80422-2
Autor:
Boyd A. Howell, Donald E. Kizer
Publikováno v:
Chemico-Biological Interactions. 2:235-246
Myocardial infarctions were induced in rats by injecting isoproterenol at 800 mg/kg body weight in divided doses 24 h apart. Both DNA synthesis and AMP deaminase activity were stimulated by this regimen, with peak stimulation of both occurring about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039b12bbb6b80312bb838a33ba451e00
https://doi.org/10.1016/0009-2797(70)90026-8
https://doi.org/10.1016/0009-2797(70)90026-8
Publikováno v:
Experimental Biology and Medicine. 124:1025-1029
SummaryWhen either thioacetamide or 3′ methyl-4-dimethylaminoazobenzene (3′Me-DAB) was injected intraabdominally into rats, liver adenylic acid (5′AMP) deaminase activity was significantly increased. When these two carcinogens were administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e37867e0f423f0e7381a2ce4b6a89d
https://doi.org/10.3181/00379727-124-31914
https://doi.org/10.3181/00379727-124-31914
Publikováno v:
Biochemical Pharmacology. 19:1263-1276
The objective in these experiments was to determine whether increases in hepatic AMP deaminase activity after ingestion or injection of the hepatocarcinogens, 3'-methyl-4-dimethylaminoazobenzene or thioacetamide, were associated with increased enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b001151fe7e3ad6c63224458060f163f
https://doi.org/10.1016/0006-2952(70)90041-9
https://doi.org/10.1016/0006-2952(70)90041-9