S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Autor: Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Céline Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombès, Johannes Roth, Maria Laura Gennaro, Frédéric Bouillaud, Sarra Cristofari, Morgane Bomsel

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al. sh

Externí odkaz: https://doaj.org/article/be4adefe3e1746e2b5a3c0fe5fcdf2f3

Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived Cardiomyocytes

Autor: Xiaochen Huang, Boxin Huang, Yong He, Liang Feng, Jian Shi, Li Wang, Juan Peng, Yong Chen

Publikováno v: Advanced biology. 6(7)

Sars-Cov-2 may trigger molecular and functional alterations of cardiomyocytes (CMs) of the heart due to the presence of receptor angiotensin-converting enzyme 2 (ACE2) of the host cells. While the endocytic itinerary of the virus via cleavage of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854388415d045a19fc80190caea9c189
https://pubmed.ncbi.nlm.nih.gov/35523737

S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Autor: Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Céline Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombès, Johannes Roth, Maria Laura Gennaro, Frédéric Bouillaud, Sarra Cristofari, Morgane Bomsel

Publikováno v: Nature Communications
Nature Communications, 2022, ⟨10.1038/s41467-022-33401-x⟩
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-33401-x⟩

HIV-1 eradication is hindered by viral persistence in cell reservoirs, established not only in circulatory CD4+T-cells but also in tissue-resident macrophages. The nature of macrophage reservoirs and mechanisms of persistence despite combined anti-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2109f06b30ee44e0e80ae395e0b610f
https://pubmed.ncbi.nlm.nih.gov/36220814

Fabrication of ultrathin artificial basement membrane for epithelial cell culture

Autor: Boxin Huang, Juan Peng, Yong He, Li Wang, Yong Chen, Elrade Rofaani

Publikováno v: Microelectronic Engineering
Microelectronic Engineering, Elsevier, 2020, 232, pp.111407. ⟨10.1016/j.mee.2020.111407⟩

International audience; Basement membranes are essential for epithelial and endothelial tissue organization. To mimic them, we developed a fabrication method to produce ultrathin membrane of collagen IV and laminin. A honeycomb microframe of thicknes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98cd4d2f7a9de2232006d9cb664df11
https://hal.archives-ouvertes.fr/hal-03013350

Fabrication of micro-cages and caged tumor spheroids for microfluidic chip- based assays

Autor: Boxin Huang, Yuanhui Liu, Li Wang, Carole Aimé, Jie Hu, Jian Shi, Yong Chen, Yong He, Elrade Rofaani, Gabriele Pitingolo

Publikováno v: Microelectronic Engineering
Microelectronic Engineering, Elsevier, 2020, 225, pp.111256. ⟨10.1016/j.mee.2020.111256⟩

International audience; We developed a simple method to fabricate micro-cages and caged tumor spheroids for microfluidic chip-based assays. The micro-cage device consists of an array of honeycomb compartments with a monolayer of cross-linked and agar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b972694d7068a588c040fc83c683d5
https://hal.sorbonne-universite.fr/hal-02565343/file/1-s2.0-S0167931720300447-main.pdf