Enlarged perivascular space burden associations with arterial stiffness and cognition.

Autor: Bown CW; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Khan OA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Liu D; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Remedios SW; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Pechman KR; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Terry JG; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Nair S; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Davis LT; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Landman BA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Gifford KA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Carr JJ; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jefferson AL; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: angela.jefferson@vumc.org.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2023 Apr; Vol. 124, pp. 85-97. Date of Electronic Publication: 2022 Nov 05.

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.

Autor: Bown CW; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Khan OA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biostatistics (O.A.K., D.L.), Vanderbilt University Medical Center, Nashville, TN., Moore EE; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Liu D; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biostatistics (O.A.K., D.L.), Vanderbilt University Medical Center, Nashville, TN., Pechman KR; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Cambronero FE; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Terry JG; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Nair S; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Davis LT; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Gifford KA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Landman BA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Engineering (B.A.L., A.L.J.), Vanderbilt University, Nashville, TN.; Department of Electrical Engineering and Computer Science (B.A.L.), Vanderbilt University, Nashville, TN., Hohman TJ; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute (T.J.H.), Vanderbilt University Medical Center, Nashville, TN., Carr JJ; Division of Cardiovascular Medicine, Department of Medicine (J.J.C.), Vanderbilt University Medical Center, Nashville, TN., Jefferson AL; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Engineering (B.A.L., A.L.J.), Vanderbilt University, Nashville, TN.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Dec; Vol. 41 (12), pp. 3015-3024. Date of Electronic Publication: 2021 Oct 28.

Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults.

Autor: Bown CW; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States., Do R; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, United states., Khan OA; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Liu D; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Cambronero FE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States., Moore EE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, United states., Osborn KE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Gupta DK; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Heart Imaging Core Lab, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, United States., Pechman KR; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Mendes LA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States., Gifford KA; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Publikováno v: Frontiers in psychology [Front Psychol] 2020 Nov 09; Vol. 11, pp. 569355. Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).

Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition.

Autor: Osborn KE; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Khan OA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Kresge HA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Bown CW; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Liu D; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Moore EE; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Gifford KA; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Acosta LMY; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Bell SP; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Divisions of Cardiovascular and Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK., Jefferson AL; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2019 Oct 22; Vol. 11, pp. 700-709. Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).

Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice.

Autor: Mi DJ; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dixit S; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Warner TA; Division of Neurology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kennard JA; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Scharf DA; Undergraduate Program in Neuroscience, Vanderbilt University, Nashville, TN, USA., Kessler ES; Undergraduate Program in Neuroscience, Vanderbilt University, Nashville, TN, USA., Moore LM; Undergraduate Program in Neuroscience, Vanderbilt University, Nashville, TN, USA., Consoli DC; Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN, USA., Bown CW; Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN, USA., Eugene AJ; Undergraduate Program in Neuroscience, Vanderbilt University, Nashville, TN, USA., Kang JQ; Division of Neurology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Harrison FE; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: Fiona.harrison@vanderbilt.edu.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2018 Nov; Vol. 71, pp. 241-254. Date of Electronic Publication: 2018 Aug 07.