Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets.

Autor: Nacev BA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA.; The Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, 10065, NY, USA., Sanchez-Vega F; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Smith SA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Rosenbaum E; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Shi H; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Tang C; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medical College, New York, 10065, NY, USA., Socci ND; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Rana S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Gularte-Mérida R; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Zehir A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Gounder MM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Bowler TG; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Luthra A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Jadeja B; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Okada A; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Strong JA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Stoller J; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Chan JE; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Chi P; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., D'Angelo SP; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Dickson MA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Kelly CM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Keohan ML; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Movva S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Thornton K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Meyers PA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Wexler LH; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Slotkin EK; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Glade Bender JL; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Shukla NN; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Hensley ML; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA., Healey JH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., La Quaglia MP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Surgery, Weill Cornell Medical College, New York, 10065, NY, USA., Alektiar KM; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Crago AM; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Surgery, Weill Cornell Medical College, New York, 10065, NY, USA., Yoon SS; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Surgery, Weill Cornell Medical College, New York, 10065, NY, USA., Untch BR; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Surgery, Weill Cornell Medical College, New York, 10065, NY, USA., Chiang S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Agaram NP; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Hameed MR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Berger MF; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Solit DB; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Schultz N; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Ladanyi M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA., Singer S; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA. singers@mskcc.org.; Department of Surgery, Weill Cornell Medical College, New York, 10065, NY, USA. singers@mskcc.org., Tap WD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA. tapw@mskcc.org.; Department of Medicine, Weill Cornell Medical College, New York, 10065, NY, USA. tapw@mskcc.org.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 15; Vol. 13 (1), pp. 3405. Date of Electronic Publication: 2022 Jun 15.

Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions.

Autor: Bowler TG; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Pradhan K; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Kong Y; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Bartenstein M; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Morrone KA; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Sridharan A; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Kessel RM; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Shastri A; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Giricz O; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Bhagat TD; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Gordon-Mitchell S; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Rohanizadegan M; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Hooda L; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Datt I; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Przychodzen BP; Cleveland Clinic, Cleveland, OH, USA., Parmar S; MD Anderson Cancer Center, Houston, TX, USA., Maqbool S; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Maciejewski JP; Cleveland Clinic, Cleveland, OH, USA., Steidl U; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Greally JM; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA., Verma A; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Publikováno v: Leukemia & lymphoma [Leuk Lymphoma] 2019 Dec; Vol. 60 (13), pp. 3132-3137. Date of Electronic Publication: 2019 Jul 10.

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor.

Autor: Vitiello GA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Medina BD; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Zeng S; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Bowler TG; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Zhang JQ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Loo JK; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Param NJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Liu M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Moral AJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Zhao JN; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Rossi F; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Balachandran VP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Cross JR; The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York., DeMatteo RP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. Ronald.dematteo@uphs.upenn.edu.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Feb 15; Vol. 24 (4), pp. 972-984. Date of Electronic Publication: 2017 Dec 15.