Výsledky vyhledávání - "Bowie Y. Cheng"

Figure S3 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

Oncomine analysis shows IRAK1 overexpression in cancers of breast, bladder, brain, colon, lung and ovary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ad65ef67c6e9923695a339bf309f14
https://doi.org/10.1158/0008-5472.22418030

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Figure S7 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

Putative AP-1 binding site in AKR1B10 promoter region was identified and AP-1 activity was consistently reduced upon knockdown of AKR1B10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682b6e3c87b6411c6a608250b6ddd3f0
https://doi.org/10.1158/0008-5472.22418018.v1

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Supplementary Information from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

Suppl Materials, Figure Legends 1-7 and Tables showing clinico-pathological correlation of endogenous IRAK1, the effect of IRAK1 alternations on tumorigenicity as well as pathway analysis of HCC cells with or without IRAK1 suppressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98afc1d5d561c24c6b71344a168c80c9
https://doi.org/10.1158/0008-5472.22418015

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Figure S5 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

By qPCR analysis, AKR1B10 was found to be overexpressed in a cohort of 79 HCC patients. AKR1B10 expression was significantly correlated with IRAK1 in our patient cohort as well as the publicly available dataset

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c219f0a45c345753ed82d022772218
https://doi.org/10.1158/0008-5472.22418024.v1

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Figure S6 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

Knockdown of AKR1B10 suppressed liver T-IC properties including sphere formation, sorafenib resistance and expression of T-IC markers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473d00985fa4d3c0bfc86f2f8ebf07f8
https://doi.org/10.1158/0008-5472.22418021

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Figure S1 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

RNA sequencing data analysis shows genetic alternations of Toll-like receptor (TLR)/Interleukin-1 receptor (IL1R) mediated signaling in which IRAK1, a serine/threonine kinase, was found to be mostly upregulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c58fd9867cbbfc7dd27bc600a002f37
https://doi.org/10.1158/0008-5472.22418036.v1

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Data from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

Frequent relapse and drug resistance in patients with hepatocellular carcinoma (HCC) can be attributed to the existence of tumor-initiating cells (TIC) within the tumor bulk. Therefore, targeting liver TICs may improve the prognosis of these patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbedac19678dd7e170ef711bfc93d3f
https://doi.org/10.1158/0008-5472.c.6510008.v1

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Figure S2 from IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Autor: Terence K. Lee, Irene Oi-Lin Ng, Stephanie Ma, Regina Cheuk-Lam Lo, Chi Ho Lin, Lily K. Cheng, Shilpa Gurung, Nicole P. Ho, Carmen Oi-Ning Leung, Hoi-Wing Leung, Eunice Y. Lau, Bowie Y. Cheng

qPCR and western blot analyses show no correlation between mRNA and protein levels of IRAK4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb38b537df74b9c6adb8fc988a52806
https://doi.org/10.1158/0008-5472.22418033

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