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Binding and dimerization of PGLa peptides in anionic lipid bilayer studied by replica exchange molecular dynamics.

Autor: Bowers SR; School of Systems Biology, George Mason University, Manassas, VA, 20110, USA., Lockhart C; School of Systems Biology, George Mason University, Manassas, VA, 20110, USA., Klimov DK; School of Systems Biology, George Mason University, Manassas, VA, 20110, USA. dklimov@gmu.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 29; Vol. 14 (1), pp. 4972. Date of Electronic Publication: 2024 Feb 29.

Mechanisms of Binding of Antimicrobial Peptide PGLa to DMPC/DMPG Membrane.

Autor: Bowers SR; School of Systems Biology, George Mason University, Manassas, Virginia 20110, United States., Klimov DK; School of Systems Biology, George Mason University, Manassas, Virginia 20110, United States., Lockhart C; School of Systems Biology, George Mason University, Manassas, Virginia 20110, United States.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2022 Mar 28; Vol. 62 (6), pp. 1525-1537. Date of Electronic Publication: 2022 Mar 10.

GA4GH: International policies and standards for data sharing across genomic research and healthcare.

Autor: Rehm HL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Brigham, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Page AJH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Global Alliance for Genomics and Health, Toronto, ON, Canada., Smith L; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Adams JB; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Alterovitz G; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Babb LJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barkley MP; DNAstack, Toronto, ON, Canada., Baudis M; University of Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Beauvais MJS; Global Alliance for Genomics and Health, Toronto, ON, Canada.; McGill University, Montreal, QC, Canada., Beck T; University of Leicester, Leicester, UK., Beckmann JS; University of Lausanne, Lausanne, Switzerland., Beltran S; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Bernick D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bernier A; McGill University, Montreal, QC, Canada., Bonfield JK; Wellcome Sanger Institute, Hinxton, UK., Boughtwood TF; Australian Genomics, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia., Bourque G; McGill University, Montreal, QC, Canada.; Canadian Center for Computational Genomics, Montreal, QC, Canada., Bowers SR; Wellcome Sanger Institute, Hinxton, UK., Brookes AJ; University of Leicester, Leicester, UK., Brudno M; Canadian Center for Computational Genomics, Montreal, QC, Canada.; University of Toronto, Toronto, ON, Canada.; University Health Network, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada.; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada., Brush MH; Oregon Health and Science University, Portland, OR, USA., Bujold D; McGill University, Montreal, QC, Canada.; Canadian Center for Computational Genomics, Montreal, QC, Canada.; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada., Burdett T; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Buske OJ; PhenoTips, Toronto, ON, Canada., Cabili MN; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cameron DL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia., Carroll RJ; Vanderbilt University Medical Center, Nashville, TN, USA., Casas-Silva E; Kelly Government Solutions, Rockville, MD, USA., Chakravarty D; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chaudhari BP; Nationwide Children's Hospital, Columbus, OH, USA.; The Ohio State University, Columbus, OH, USA., Chen SH; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Cherry JM; Stanford University, Stanford, CA, USA., Chung J; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Cline M; UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA., Clissold HL; Wellcome Sanger Institute, Hinxton, UK., Cook-Deegan RM; Arizona State University, Washington, DC, USA., Courtot M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Cunningham F; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Cupak M; DNAstack, Toronto, ON, Canada., Davies RM; Wellcome Sanger Institute, Hinxton, UK., Denisko D; University of Toronto, Toronto, ON, Canada., Doerr MJ; Sage Bionetworks, Seattle, WA, USA., Dolman LI; University of Toronto, Toronto, ON, Canada., Dove ES; University of Edinburgh, Edinburgh, UK., Dursi LJ; University Health Network, Toronto, ON, Canada.; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada., Dyke SOM; McGill University, Montreal, QC, Canada., Eddy JA; Sage Bionetworks, Seattle, WA, USA., Eilbeck K; University of Utah, Salt Lake City, UT, USA., Ellrott KP; Oregon Health and Science University, Portland, OR, USA., Fairley S; Global Alliance for Genomics and Health, Toronto, ON, Canada.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Fakhro KA; Sidra Medicine, Doha, Qatar.; Weill Cornell Medicine - Qatar, Doha, Qatar., Firth HV; Wellcome Sanger Institute, Hinxton, UK.; Addenbrooke's Hospital, Cambridge, UK., Fitzsimons MS; University of Chicago, Chicago, IL, USA., Fiume M; DNAstack, Toronto, ON, Canada., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Fore IM; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Freeberg MA; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Freimuth RR; Mayo Clinic, Rochester, MN, USA., Fromont LA; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Fuerth J; DNAstack, Toronto, ON, Canada., Gaff CL; Australian Genomics, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia.; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia., Gan W; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Ghanaim EM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Glazer D; Verily Life Sciences, South San Francisco, CA, USA., Green RC; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Griffith M; Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Griffith OL; Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Grossman RL; University of Chicago, Chicago, IL, USA., Groza T; Pryzm Health, Sydney, QLD, Australia., Auvil JMG; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Guigó R; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Gupta D; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Haendel MA; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hamosh A; Johns Hopkins University, Baltimore, MD, USA., Hansen DP; Australian Genomics, Parkville, VIC, Australia.; The Australian e-Health Research Centre, CSIRO, Herston, QLD, Australia., Hart RK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Invitae, San Francisco, CA, USA.; MyOme, Inc, San Bruno, CA, USA., Hartley DM; Autism Speaks, Princeton, NJ, USA., Haussler D; UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA.; Howard Hughes Medical Institute, University of California, Santa Cruz, CA, USA., Hendricks-Sturrup RM; Duke-Margolis Center for Health Policy, Washington, DC, USA., Ho CWL; The University of Hong Kong, Hong Kong, Hong Kong., Hobb AE; DNAstack, Toronto, ON, Canada., Hoffman MM; University of Toronto, Toronto, ON, Canada.; University Health Network, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada., Hofmann OM; University of Toronto, Toronto, ON, Canada.; University of Melbourne, Melbourne, VIC, Australia., Holub P; BBMRI-ERIC, Graz, Austria.; Masaryk University, Brno, Czech Republic., Hsu JS; National Taiwan University, Taipei City, Taiwan., Hubaux JP; École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Hunt SE; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Husami A; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Jacobsen JO; Queen Mary University of London, London, UK., Jamuar SS; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore., Janes EL; Global Alliance for Genomics and Health, Toronto, ON, Canada.; University of Waterloo, Waterloo, ON, Canada., Jeanson F; Datadex Inc., Toronto, ON, Canada., Jené A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Johns AL; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Joly Y; McGill University, Montreal, QC, Canada., Jones SJM; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada., Kanitz A; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University of Basel, Basel, Switzerland., Kato K; Osaka University, Suita, Japan., Keane TM; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; University of Nottingham, Nottingham, UK., Kekesi-Lafrance K; Global Alliance for Genomics and Health, Toronto, ON, Canada.; McGill University, Montreal, QC, Canada., Kelleher J; University of Oxford, Oxford, UK., Kerry G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Khor SS; National Center for Global Health and Medicine Hospital, Tokyo, Japan.; University of Tokyo, Tokyo, Japan., Knoppers BM; McGill University, Montreal, QC, Canada., Konopko MA; ELIXIR Hub, Hinxton, UK., Kosaki K; Keio University School of Medicine, Tokyo, Japan., Kuba M; Masaryk University, Brno, Czech Republic., Lawson J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Leinonen R; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Li S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Global Alliance for Genomics and Health, Toronto, ON, Canada., Lin MF; mlin.net LLC, San Jose, CA, USA., Linden M; CSC-IT Center for Science, Espoo, Finland.; ELIXIR Finland, Espoo, Finland., Liu X; University of Waterloo, Waterloo, ON, Canada., Udara Liyanage I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Lopez J; Genomics England, London, UK., Lucassen AM; Faculty of Medicine, University Southampton, Southampton, UK., Lukowski M; University of Chicago, Chicago, IL, USA., Mann AL; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Wellcome Sanger Institute, Hinxton, UK., Marshall J; University of Glasgow, Glasgow, UK., Mattioni M; Seven Bridges, Boston, MA, USA., Metke-Jimenez A; The Australian e-Health Research Centre, CSIRO, Herston, QLD, Australia., Middleton A; Wellcome Connecting Science, Hinxton, UK.; University of Cambridge, Cambridge, UK., Milne RJ; Wellcome Connecting Science, Hinxton, UK.; University of Cambridge, Cambridge, UK., Molnár-Gábor F; Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany., Mulder N; H3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa., Munoz-Torres MC; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nag R; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Nakagawa H; Japan Agency for Medical Research & Development (AMED), Tokyo, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Nasir J; University of Northampton, Northampton, UK., Navarro A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Nelson TH; Genomic Medicine Institute, Geisinger, Danville, PA, USA., Niewielska A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Nisselle A; Murdoch Children's Research Institute, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia.; Human Genetics Society of Australasia Education, Ethics & Social Issues Committee, Alexandria, NSW, Australia., Niu J; University Health Network, Toronto, ON, Canada., Nyrönen TH; CSC-IT Center for Science, Espoo, Finland.; ELIXIR Finland, Espoo, Finland., O'Connor BD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Oesterle S; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ogishima S; Tohoku University, Sendai, Japan., Wang VO; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Paglione LAD; Spherical Cow Group, New York, NY, USA.; Laura Paglione LLC, New York, NY, USA., Palumbo E; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Parkinson HE; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Philippakis AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pizarro AD; Amazon Web Services, Inc., Seattle, WA, USA., Prlic A; Invitae, San Francisco, CA, USA., Rambla J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Rendon A; Genomics England, London, UK., Rider RA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Robinson PN; The Jackson Laboratory, Farmington, CT, USA.; University of Connecticut, Farmington, CT, USA., Rodarmer KW; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Rodriguez LL; Patient-Centered Outcomes Research Institute (PCORI), Washington, DC, USA., Rubin AF; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia., Rueda M; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Rushton GA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ryan RS; Bicgen Foundation Inc, Arlington Heights, IL, USA., Saunders GI; ELIXIR Hub, Hinxton, UK., Schuilenburg H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Schwede T; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University of Basel, Basel, Switzerland., Scollen S; ELIXIR Hub, Hinxton, UK., Senf A; Congenica Ltd., Cambridge, UK., Sheffield NC; University of Virginia, Charlottesville, VA, USA., Skantharajah N; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Smith AV; University of Michigan, Ann Arbor, MI, USA., Sofia HJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Spalding D; CSC-IT Center for Science, Espoo, Finland.; ELIXIR Finland, Espoo, Finland., Spurdle AB; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Stark Z; Australian Genomics, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia., Stein LD; Ontario Institute for Cancer Research, Toronto, ON, Canada.; University of Toronto, Toronto, ON, Canada., Suematsu M; Keio University School of Medicine, Tokyo, Japan., Tan P; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore.; Precision Health Research Singapore, Singapore, Republic of Singapore.; Genome Institute of Singapore, Singapore, Republic of Singapore., Tedds JA; ELIXIR Hub, Hinxton, UK., Thomson AA; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Thorogood A; McGill University, Montreal, QC, Canada.; University of Luxembourg, Esch-sur-Alzette, Luxembourg., Tickle TL; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tokunaga K; University of Tokyo, Tokyo, Japan.; National Center for Global Health and Medicine, Tokyo, Japan., Törnroos J; CSC-IT Center for Science, Espoo, Finland.; ELIXIR Finland, Espoo, Finland., Torrents D; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.; Barcelona Supercomputing Center, Barcelona, Spain., Upchurch S; California Institute of Technology, Pasadena, CA, USA., Valencia A; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.; Barcelona Supercomputing Center, Barcelona, Spain., Guimera RV; University of Melbourne, Melbourne, VIC, Australia., Vamathevan J; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Varma S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; Health Data Research UK, London, UK., Vears DF; Murdoch Children's Research Institute, Parkville, VIC, Australia.; University of Melbourne, Melbourne, VIC, Australia.; Human Genetics Society of Australasia Education, Ethics & Social Issues Committee, Alexandria, NSW, Australia.; Melbourne Law School, University of Melbourne, Parkville, VIC, Australia., Viner C; University of Toronto, Toronto, ON, Canada.; University Health Network, Toronto, ON, Canada., Voisin C; Google LLC, Kitchener, ON, Canada., Wagner AH; Nationwide Children's Hospital, Columbus, OH, USA.; The Ohio State University, Columbus, OH, USA., Wallace SE; University of Leicester, Leicester, UK., Walsh BP; Oregon Health and Science University, Portland, OR, USA., Williams MS; Genomic Medicine Institute, Geisinger, Danville, PA, USA., Winkler EC; Section of Translational Medical Ethics, University Hospital Heidelberg, Heidelberg, Germany., Wold BJ; California Institute of Technology, Pasadena, CA, USA., Wood GM; Salt Lake City, UT, USA., Woolley JP; University of Oxford, Oxford, UK., Yamasaki C; Osaka University, Suita, Japan., Yates AD; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Yung CK; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Indoc Research, Toronto, ON, Canada., Zass LJ; H3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa., Zaytseva K; McGill University, Montreal, QC, Canada.; Canadian Centre for Computational Genomics, Montreal, QC, Canada., Zhang J; Ontario Institute for Cancer Research, Toronto, ON, Canada., Goodhand P; Global Alliance for Genomics and Health, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., North K; Murdoch Children's Research Institute, Parkville, VIC, Australia.; University of Toronto, Toronto, ON, Canada.; University of Melbourne, Melbourne, VIC, Australia., Birney E; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; European Molecular Biology Laboratory, Heidelberg, Germany.

Publikováno v: Cell genomics [Cell Genom] 2021 Nov 10; Vol. 1 (2).