Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo .

Autor: Jamaluddin A; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Chuang CL; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Williams ET; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Siow A; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Yang SH; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Harris PWR; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Petersen JSSM; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Bower RL; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Chand S; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Brimble MA; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Walker CS; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Hay DL; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand., Loomes KM; School of Biological Sciences, University of Auckland, Auckland, New Zealand.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2022 Mar 07; Vol. 13, pp. 832589. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).

Synthesis and Biological Evaluation of (-) and (+)-Spiroleucettadine and Analogues.

Autor: Badart MP; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand., Barnes EM; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand., Cording AP; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand., Gilmer SCL; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand., Billinghurst ID; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand., Edupuganti VVSR; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand., Lessene G; ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3050, Australia., Bland AR; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9054, New Zealand., Bower RL; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9054, New Zealand., Rana Z; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9054, New Zealand., Ferguson SA; Department of Microbiology and Immunology, University of Otago, Dunedin, 9054, New Zealand., Opel Reading HK; Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand., Cook GM; Department of Microbiology and Immunology, University of Otago, Dunedin, 9054, New Zealand., Rosengren RJ; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9054, New Zealand., Krause KL; Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand., Gamble AB; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand., Ashton JC; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9054, New Zealand., Hawkins BC; Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand.

Publikováno v: ChemMedChem [ChemMedChem] 2021 Apr 20; Vol. 16 (8), pp. 1308-1315. Date of Electronic Publication: 2021 Jan 26.

Inhibition of Mitogen-Activated Protein Kinase Kinase Alone and in Combination with Anaplastic Lymphoma Kinase (ALK) Inhibition Suppresses Tumor Growth in a Mouse Model of ALK-Positive Lung Cancer.

Autor: Shrestha N; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Bland AR; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Bower RL; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Rosengren RJ; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Ashton JC; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand john.ashton@otago.ac.nz.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Jul; Vol. 374 (1), pp. 134-140. Date of Electronic Publication: 2020 Apr 13.

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.

Autor: Hendrikse ER; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Liew LP; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand., Bower RL; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Bonnet M; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand., Jamaluddin MA; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Prodan N; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand., Richards KD; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand., Walker CS; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Pairaudeau G; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom., Smith DM; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom., Rujan RM; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Sudra R; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Reynolds CA; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Booe JM; Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Pioszak AA; Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Flanagan JU; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Hay MP; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Hay DL; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2020 Mar 12; Vol. 3 (2), pp. 305-320. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).

Molecular studies of CGRP and the CGRP family of peptides in the central nervous system.

Autor: Hendrikse ER; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand., Bower RL; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand., Hay DL; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand.; 2 Centre for Brain Research, University of Auckland, Auckland, New Zealand., Walker CS; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand.

Publikováno v: Cephalalgia : an international journal of headache [Cephalalgia] 2019 Mar; Vol. 39 (3), pp. 403-419. Date of Electronic Publication: 2018 Mar 22.