N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.

Autor: Hoveyda HR; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium. Electronic address: hamidhoveyda@hotmail.com., Fraser GL; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Zoute L; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Dutheuil G; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Schils D; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Brantis C; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Lapin A; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Parcq J; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Guitard S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Lenoir F; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Bousmaqui ME; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Rorive S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Hospied S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Blanc S; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Bernard J; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., Ooms F; Ogeda SA (formerly Euroscreen), 47, rue Adrienne Bolland, 6041 Gosselies, Belgium., McNelis JC; University of California, Department of Medicine, San Diego, CA 92161, USA., Olefsky JM; University of California, Department of Medicine, San Diego, CA 92161, USA.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Oct 01; Vol. 26 (18), pp. 5169-5180. Date of Electronic Publication: 2018 Sep 18.