The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

Autor: Wesselius Anke, Bours Martijn JL, Arts Ilja CW, Theunisz Esther HE, Geusens Piet, Dagnelie Pieter C

Publikováno v: BMC Immunology, Vol 13, Iss 1, p 64 (2012)

Abstract Background The P2X7 receptor plays an important role in cytokine release during the inflammatory response in vivo. Polymorphisms within the P2X7 receptor gene that lead to loss of receptor function may contribute to impaired cytokine release

Externí odkaz: https://doaj.org/article/2e6826a92fe4470fb712022750928e34

Effects of oral adenosine 5'-triphosphate and adenosine in enteric-coated capsules on indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study

Autor: Bours Martijn JL, Bos Hilde J, Meddings Jon B, Brummer Robert-Jan M, van den Brandt Piet A, Dagnelie Pieter C

Publikováno v: BMC Gastroenterology, Vol 7, Iss 1, p 23 (2007)

Abstract Background It is well-known that nonsteroidal anti-inflammatory drugs (NSAIDs) can cause damage to the small bowel associated with disruption of mucosal barrier function. In healthy human volunteers, we showed previously that topical adminis

Externí odkaz: https://doaj.org/article/6dc55343c99843b3a8c3600f288a16f6

Non-synonymous polymorphisms in the P2RX ( 4 ) are related to bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.

Autor: Wesselius A; Department of Epidemiology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre, P O Box 616, Peter Debyeplein 1 6229HA, 6200, MD, Maastricht, The Netherlands. anke.wesselius@maastrichtuniversity.nl, Bours MJ, Jørgensen NR, Wiley J, Gu B, van Helden S, van Rhijn L, Dagnelie PC

Publikováno v: Purinergic signalling [Purinergic Signal] 2013 Mar; Vol. 9 (1), pp. 123-30. Date of Electronic Publication: 2012 Nov 10.