Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma

Autor: Hagege, Anais, Saada-Bouzid, Esma, Ambrosetti, Damien, Rastoin, Olivia, Boyer, Julien, He, Xingkang, Rousset, Julie, Montemagno, Christopher, Doyen, Jérome, Pedeutour, Florence, Parola, Julien, Bourget, Isabelle, Luciano, Frederic, Bozec, Alexandre, Cao, Yihai, Pagès, Gilles, Dufies, Maeva

Publikováno v: In Cell Reports Medicine 20 September 2022 3(9)

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Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

Autor: Albrengues, Jean, Bertero, Thomas, Grasset, Eloise, Bonan, Stephanie, Maiel, Majdi, Bourget, Isabelle, Philippe, Claude, Herraiz Serrano, Cecilia, Benamar, Samia, Croce, Olivier, Sanz-Moreno, Victoria, Meneguzzi, Guerrino, Feral, Chloe C., Cristofari, Gael, Gaggioli, Cedric

Publikováno v: Albrengues, J, Bertero, T, Grasset, E, Bonan, S, Maiel, M, Bourget, I, Philippe, C, Herraiz Serrano, C, Benamar, S, Croce, O, Sanz-Moreno, V, Meneguzzi, G, Feral, C C, Cristofari, G & Gaggioli, C 2015, ' Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts ', Nature Communications, vol. 6, 10204 . https://doi.org/10.1038/ncomms10204

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::16a956f1f5acd2b45d83e70b469eb752
https://kclpure.kcl.ac.uk/en/publications/e754e002-aa9f-486a-a78a-736ab06b1484

Additional file 14: Figure S9. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

Autor: M. Brahimi-Horn, Giuliano, Sandy, Saland, Estelle, Lacas-Gervais, Sandra, Sheiko, Tatiana, Pelletier, Joffrey, Bourget, Isabelle, Bost, Frédéric, Féral, Chloé, Boulter, Etienne, Tauc, Michel, Ivan, Mircea, Garmy-Susini, Barbara, Popa, Alexandra, Mari, Bernard, Jean-Emmanuel Sarry, Craigen, William, Pouysségur, Jacques, Mazure, Nathalie

Autophagy was detected in Vdac1 −/− MEF. (A) Representative images of electron micrographs of Wt and Vdac1 −/− MEF incubated in normoxia (Nx) for 24 h. Vdac1 −/− MEF showed autophagosomes with double membranes (arrow). (B) Wt and Vdac1 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c25968ebeff1424848611042d61709c

Additional file 8: Figure S3. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

Autor: M. Brahimi-Horn, Giuliano, Sandy, Saland, Estelle, Lacas-Gervais, Sandra, Sheiko, Tatiana, Pelletier, Joffrey, Bourget, Isabelle, Bost, Frédéric, Féral, Chloé, Boulter, Etienne, Tauc, Michel, Ivan, Mircea, Garmy-Susini, Barbara, Popa, Alexandra, Mari, Bernard, Jean-Emmanuel Sarry, Craigen, William, Pouysségur, Jacques, Mazure, Nathalie

Cytochrome oxidase expression: (A) Immunofluorescence to COX4-2 in Wt and Vdac1 −/− MEF in Nx for 72 h and (B) COX4-2 in Wt and Vdac1 −/− MEF in Hx for 72 h in the absence (Ctl) or presence of the MEK inhibitor (PD184352).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaacb178e4f4fbcc023d13a3ea031c4