Methylthioadenosine suppresses Salmonella virulence

Autor: Bourgeois, JS, Zhou, D, Thurston, TLM, Gilchrist, JJ, Ko, DC

In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously we showed transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) in

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https://ora.ox.ac.uk/objects/uuid:d8cc7fb0-426f-4b96-8c16-a6b91c906cdf

Comparative reservoir competence of Peromyscus leucopus , C57BL/6J, and C3H/HeN for Borrelia burgdorferi B31.

Autor: Bourgeois JS; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA., You SS; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA., Clendenen LH; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA., Shrestha M; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA., Petnicki-Ocwieja T; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA., Telford SR 3rd; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA.; Department of Infectious Disease and Global Health, Tufts University, North Grafton, Massachusetts, USA., Hu LT; Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.; Tufts University, Tufts Lyme Disease Initiative, Boston, Massachusetts, USA.

Publikováno v: Applied and environmental microbiology [Appl Environ Microbiol] 2024 Jul 24; Vol. 90 (7), pp. e0082224. Date of Electronic Publication: 2024 Jun 20.

Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation.

Autor: Gibbs KD; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Wang L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Yang Z; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Anderson CE; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Bourgeois JS; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA., Cao Y; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Gaggioli MR; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Biel M; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Puertollano R; Cell and Developmental Biology Center, National Heart, Lung, & Blood Institute, NIH, Bethesda, MD 20892, USA., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan., Ko DC; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.

Publikováno v: Cell genomics [Cell Genom] 2023 Apr 04; Vol. 3 (5), pp. 100290. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023).

Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus.

Autor: Schott BH; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.; Duke University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.; These authors contributed equally., Wang L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.; These authors contributed equally., Zhu X; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA., Harding AT; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA., Ko ER; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Hospital Medicine, Division of General Internal Medicine, Department of Medicine, Duke Regional Hospital, Durham, NC 27705, USA., Bourgeois JS; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.; Duke University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA., Washington EJ; Department of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA., Burke TW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Anderson J; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Bergstrom E; Section of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK., Gardener Z; Section of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK., Paterson S; Section of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK., Brennan RG; Department of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA., Chiu C; Section of Infectious Diseases and Immunity, Imperial College London, London, W12 0NN, UK., McClain MT; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA., Woods CW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA., Heaton NS; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA., Ko DC; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, 0048B CARL Building Box 3053, 213 Research Drive, Durham, NC 27710, USA.; Duke University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Lead contact.

Publikováno v: Cell genomics [Cell Genom] 2022 Nov 09; Vol. 2 (11).

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.

Autor: Bourgeois JS; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America.; University Program in Genetics and Genomics, Duke University, Durham, North Carolina, United States of America., Wang L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America., Rabino AF; Department of Biological Sciences, University of Toledo, Toledo, Ohio, United States of America., Everitt J; Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America., Alvarez MI; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America., Awadia S; Department of Biological Sciences, University of Toledo, Toledo, Ohio, United States of America., Wittchen ES; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America., Garcia-Mata R; Department of Biological Sciences, University of Toledo, Toledo, Ohio, United States of America., Ko DC; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America.; University Program in Genetics and Genomics, Duke University, Durham, North Carolina, United States of America.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Jul 09; Vol. 17 (7), pp. e1009713. Date of Electronic Publication: 2021 Jul 09 (Print Publication: 2021).