Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome.

Autor: Fajtova P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, Czech Republic.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Hurysz BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Miyamoto Y; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA., Serafim MSM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Jiang Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Vazquez JM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Trujillo DF; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Liu LJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Somani U; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Almaliti J; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA., Myers SA; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, California, USA., Caffrey CR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA., Gerwick WH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA., McMinn DL; Kezar Life Sciences, South San Francisco, California, USA., Kirk CJ; Kezar Life Sciences, South San Francisco, California, USA., Boura E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, Czech Republic., Eckmann L; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5225.

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors.

Autor: Silhan J; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic., Fajtova P; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic. fajtova@uochb.cas.cz.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. fajtova@uochb.cas.cz., Bartosova J; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic., Hurysz BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Almaliti J; Department Pharmaceutical Sciences, College of Pharmacy, The University of Jordan, Amman, Jordan.; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Miyamoto Y; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Eckmann L; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Gerwick WH; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. ajodonoghue@health.ucsd.edu.; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA. ajodonoghue@health.ucsd.edu., Boura E; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, Czech Republic. boura@uochb.cas.cz.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 04; Vol. 15 (1), pp. 8621. Date of Electronic Publication: 2024 Oct 04.

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.

Autor: Kocek H; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz.; Faculty of Chemical Technology, University of Chemistry and Technology Prague Czech Republic., Chalupská D; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Dejmek M; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Dvořáková A; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Zgarbová M; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz.; Department of Genetics and Microbiology, Faculty of Science, Charles University Prague Czech Republic., Šála M; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Chalupský K; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Krafčíková P; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Otava T; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz.; Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague Czech Republic., Drexler M; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Procházková E; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Klepetářová B; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Štefek M; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz.; Department of Organic Chemistry, Faculty of Science, Charles University Prague Czech Republic., Kozic J; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Mertlíková-Kaiserová H; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Boura E; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Weber J; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz., Nencka R; Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences Prague Czech Republic nencka@uochb.cas.cz.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Aug 01. Date of Electronic Publication: 2024 Aug 01.

Structure of monkeypox virus poxin: implications for drug design.

Autor: Duchoslav V; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic., Boura E; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic. boura@uochb.cas.cz.

Publikováno v: Archives of virology [Arch Virol] 2023 Jun 28; Vol. 168 (7), pp. 192. Date of Electronic Publication: 2023 Jun 28.

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.

Autor: Klima M; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Dejmek M; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Duchoslav V; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Eisenreichova A; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Sala M; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Chalupsky K; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Chalupska D; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Novotná B; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Birkuš G; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic., Nencka R; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic. Electronic address: nencka@uochb.cas.cz., Boura E; Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2., 166 10 Prague 6, Czech Republic. Electronic address: boura@uochb.cas.cz.

Publikováno v: Structure (London, England : 1993) [Structure] 2024 Apr 04; Vol. 32 (4), pp. 433-439.e4. Date of Electronic Publication: 2024 Feb 06.