Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Autor: McInnes J; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Wierda K; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Snellinx A; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Bounti L; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Wang YC; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Stancu IC; Institute of Neuroscience, Alzheimer Dementia Group, Catholic University of Louvain, 1200 Brussels, Belgium; Biomedical Research Institute, Hasselt University, 3500 Hasselt, Belgium., Apóstolo N; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Gevaert K; VIB-UGent Center for Medical Biotechnology, 9000 Ghent, Belgium; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium., Dewachter I; Institute of Neuroscience, Alzheimer Dementia Group, Catholic University of Louvain, 1200 Brussels, Belgium; Biomedical Research Institute, Hasselt University, 3500 Hasselt, Belgium., Spires-Jones TL; UK Dementia Research Institute, Euan MacDonald Centre, and Centre for Dementia Prevention, Edinburgh Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK., De Strooper B; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium; Dementia Research Institute, University College London, London WC1E 6BT, UK., De Wit J; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Zhou L; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium., Verstreken P; VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: patrik.verstreken@kuleuven.vib.be.

Publikováno v: Neuron [Neuron] 2018 Feb 21; Vol. 97 (4), pp. 823-835.e8. Date of Electronic Publication: 2018 Feb 01.

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.

Autor: Vanhauwaert R; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Kuenen S; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Masius R; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Bademosi A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia., Manetsberger J; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Schoovaerts N; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Bounti L; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Gontcharenko S; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Swerts J; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Vilain S; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Picillo M; Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy., Barone P; Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy., Munshi ST; Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands., de Vrij FM; Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands., Kushner SA; Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands., Gounko NV; VIB Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium.; Electron Microscopy Platform, VIB Bio-Imaging Core, Leuven, Belgium., Mandemakers W; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Bonifati V; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Meunier FA; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia., Soukup SF; VIB Center for Brain & Disease Research, Leuven, Belgium sandra.soukup@cme.vib-kuleuven.be patrik.verstreken@cme.vib-kuleuven.be.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium., Verstreken P; VIB Center for Brain & Disease Research, Leuven, Belgium sandra.soukup@cme.vib-kuleuven.be patrik.verstreken@cme.vib-kuleuven.be.; Department of Human Genetics, Leuven Institute for Neurodegenerative Disease (LIND), KU Leuven, Leuven, Belgium.

Publikováno v: The EMBO journal [EMBO J] 2017 May 15; Vol. 36 (10), pp. 1392-1411. Date of Electronic Publication: 2017 Mar 22.

Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

Autor: Hegde RN; Institute of Protein Biochemistry, National Research Council, Naples, Italy.; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Parashuraman S; Institute of Protein Biochemistry, National Research Council, Naples, Italy.; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Iorio F; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Ciciriello F; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Biology and Biotechnology Department 'Charles Darwin', Sapienza University, Rome, Italy.; Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montréal, Canada., Capuani F; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Carissimo A; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Carrella D; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Belcastro V; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Subramanian A; Institute of Protein Biochemistry, National Research Council, Naples, Italy., Bounti L; Institute of Protein Biochemistry, National Research Council, Naples, Italy., Persico M; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Carlile G; Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montréal, Canada., Galietta L; U.O.C. Genetica Medica, Institute of Giannina Gaslini, Genova, Italy., Thomas DY; Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montréal, Canada., Di Bernardo D; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy., Luini A; Institute of Protein Biochemistry, National Research Council, Naples, Italy.; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Istituto di Ricovero e Cura a Carattere Scientifico SDN, Naples, Italy.

Publikováno v: ELife [Elife] 2015 Dec 23; Vol. 4. Date of Electronic Publication: 2015 Dec 23.

Dysfunction of synaptic endocytic trafficking in Parkinson's disease.

Autor: Xin Yi Ng, Mian Cao

Publikováno v: Neural Regeneration Research; Dec2024, Vol. 19 Issue 12, p2649-2660, 12p

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy.

Autor: Anglada-Huguet, Marta¹ (AUTHOR) marta.anglada@dzne.de, Endepols, Heike^2,3,4 (AUTHOR), Sydow, Astrid¹ (AUTHOR), Hilgers, Ronja¹ (AUTHOR), Neumaier, Bernd^2,4,5 (AUTHOR), Drzezga, Alexander^1,3,6 (AUTHOR), Kaniyappan, Senthilvelrajan^1,7,8 (AUTHOR), Mandelkow, Eckhard^1,7,8 (AUTHOR), Mandelkow, Eva-Maria^1,7 (AUTHOR) marta.anglada@dzne.de

Publikováno v: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9260. 25p.