Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses

Autor: Benzie, Graeme, Bouma, Kristen, Battellino, Taylor, Cooper, Steven, Hemming, Rick, Kammouni, Wafa, Liu, Lin, Do, Cuong, Khajehpour, Mazdak, Perreault, Helene, Kornfeld, Stuart, Triggs-Raine, Barbara, Mark, Brian L.

Publikováno v: In BBA Advances 2022 2

Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses.

Autor: Benzie G; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Bouma K; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Battellino T; Department of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada., Cooper S; Biochemistry and Medical Genetics, University of Manitoba, Canada., Hemming R; Biochemistry and Medical Genetics, University of Manitoba, Canada., Kammouni W; Biochemistry and Medical Genetics, University of Manitoba, Canada., Liu L; M6P Therapeutics, 20 S. Sarah St., St. Louis, MO 63018, United States., Do C; M6P Therapeutics, 20 S. Sarah St., St. Louis, MO 63018, United States., Khajehpour M; Department of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada., Perreault H; Department of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada., Kornfeld S; Washington University School of Medicine in St. Louis, Department of Biochemistry & Molecular Biophysics, United States., Triggs-Raine B; Biochemistry and Medical Genetics, University of Manitoba, Canada., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Publikováno v: BBA advances [BBA Adv] 2021 Dec 13; Vol. 2, pp. 100032. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2022).