Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice

Autor: Miller, CM, Zakrzewski, AM, Ikin, RJ, Boulter, NR, Katrib, M, Lees, MP, Fuller, SJ, Wiley, JS, Smith, NC

The P2X7 receptor (P2X7R) is a two transmembrane receptor that is highly expressed on the surface of immune cells. Loss of function polymorphisms in this receptor have been linked to increased susceptibility to intracellular pathogens. P2X7R gene kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::90493b6525e2be038e398c9c8852bd01
https://hdl.handle.net/10453/18531

P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

Autor: Lees, MP, Fuller, SJ, McLeod, R, Boulter, NR, Miller, CM, Zakrzewski, AM, Mui, EJ, Witola, WH, Coyne, JJ, Hargrave, AC, Jamieson, SE, Blackwell, JM, Wiley, JS, Smith, NC

The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms that decrease receptor funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::38852322050787464b56f014b71f7b02
https://hdl.handle.net/10453/17140

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The role of the P2X₇ receptor in infectious diseases.

Autor: Miller CM; Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Broadway, New South Wales, Australia., Boulter NR, Fuller SJ, Zakrzewski AM, Lees MP, Saunders BM, Wiley JS, Smith NC

Publikováno v: PLoS pathogens [PLoS Pathog] 2011 Nov; Vol. 7 (11), pp. e1002212. Date of Electronic Publication: 2011 Nov 10.

Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis.

Autor: Jamieson SE; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Peixoto-Rangel AL, Hargrave AC, Roubaix LA, Mui EJ, Boulter NR, Miller EN, Fuller SJ, Wiley JS, Castellucci L, Boyer K, Peixe RG, Kirisits MJ, Elias Lde S, Coyne JJ, Correa-Oliveira R, Sautter M, Smith NC, Lees MP, Swisher CN, Heydemann P, Noble AG, Patel D, Bardo D, Burrowes D, McLone D, Roizen N, Withers S, Bahia-Oliveira LM, McLeod R, Blackwell JM

Publikováno v: Genes and immunity [Genes Immun] 2010 Jul; Vol. 11 (5), pp. 374-83. Date of Electronic Publication: 2010 Jun 10.