The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function

Autor: Baker, LCJ, Boult, JKR, Walker-Samuel, S, Chung, Y-L, Jamin, Y, Ashcroft, M, Robinson, SP

BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) mediates the transcriptional response to hypoxic stress, promoting tumour progression and survival. This study investigated the acute effects of the small-molecule HIF-pathway inhibitor NSC-134754. METHO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03892ee274e6d5ba09d48db044dc3af1
https://www.repository.cam.ac.uk/handle/1810/308095

Tumour reoxygenation after intratumoural hydrogen peroxide (KORTUC) injection: a novel approach to enhance radiosensitivity.

Autor: Nimalasena S; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Anbalagan S; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Box C; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Yu S; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Boult JKR; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Bush N; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Howell L; Core Research Facilities, The Institute of Cancer Research, London, UK., Sinnett V; The Royal Marsden NHS Foundation Trust, London, UK., Murphy W; Biological Service Unit, The Institute of Cancer Research, London, UK., Yarnold J; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Robinson SP; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK., Somaiah N; Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK.

Publikováno v: BJC reports [BJC Rep] 2024 Oct 08; Vol. 2 (1), pp. 78. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).

Correction: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy.

Autor: Mączyńska J; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Raes F; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Da Pieve C; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Turnock S; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Boult JKR; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Hoebart J; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Niedbala M; Department of Neurosurgery, Medical University of Silesia, Regional Hospital, 41-200, Sosnowiec, Poland., Robinson SP; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Harrington KJ; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Kaspera W; Department of Neurosurgery, Medical University of Silesia, Regional Hospital, 41-200, Sosnowiec, Poland. wkaspera@sum.edu.pl., Kramer-Marek G; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK. gkramermarek@icr.ac.uk.

Publikováno v: BMC medicine [BMC Med] 2022 May 03; Vol. 20 (1), pp. 179. Date of Electronic Publication: 2022 May 03.

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy.

Autor: Mączyńska J; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Raes F; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Da Pieve C; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Turnock S; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Boult JKR; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Hoebart J; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Niedbala M; Department of Neurosurgery, Medical University of Silesia, Regional Hospital, 41-200, Sosnowiec, Poland., Robinson SP; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Harrington KJ; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Kaspera W; Department of Neurosurgery, Medical University of Silesia, Regional Hospital, 41-200, Sosnowiec, Poland. wkaspera@sum.edu.pl., Kramer-Marek G; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK. gkramermarek@icr.ac.uk.

Publikováno v: BMC medicine [BMC Med] 2022 Jan 21; Vol. 20 (1), pp. 16. Date of Electronic Publication: 2022 Jan 21.

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Autor: Clarke M; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Mackay A; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Ismer B; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Pickles JC; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Tatevossian RG; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Newman S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Bale TA; Department of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York., Stoler I; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany., Izquierdo E; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Temelso S; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Carvalho DM; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Molinari V; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Burford A; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Howell L; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Virasami A; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Fairchild AR; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Avery A; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Chalker J; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Kristiansen M; UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Haupfear K; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Dalton JD; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Orisme W; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Wen J; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Hubank M; Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom., Kurian KM; Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom., Rowe C; Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom., Maybury M; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.; Oncology Service, Queensland Children's Hospital, Brisbane, Australia.; Child Health Research Centre, The University of Queensland, South Brisbane, Australia., Crosier S; Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom., Knipstein J; Division of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin., Schüller U; Department of Neuropathology, University Hospital Hamburg-Eppendorf, and Research Institute Children's Cancer Center, Hamburg, Germany.; Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Kordes U; Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Kram DE; Section of Pediatric Hematology-Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Snuderl M; Department of Neuropathology, NYU Langone Health, New York, New York., Bridges L; Department of Neuropathology, St George's Hospital NHS Trust, London, United Kingdom., Martin AJ; Department of Neurosurgery, St George's Hospital NHS Trust, London, United Kingdom., Doey LJ; Department of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom., Al-Sarraj S; Department of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom., Chandler C; Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom., Zebian B; Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom., Cairns C; Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom., Natrajan R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Boult JKR; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom., Robinson SP; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom., Sill M; German Cancer Research Center (DKFZ), Heidelberg, Germany., Dunkel IJ; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York., Gilheeney SW; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York., Rosenblum MK; Department of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York., Hughes D; Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom., Proszek PZ; Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom., Macdonald TJ; Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia., Preusser M; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Haberler C; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Institute of Neurology, Medical University of Vienna, Vienna, Austria., Slavc I; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Packer R; Center for Neuroscience and Behavioural Medicine, Children's National Medical Center, Washington, DC., Ng HK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, China., Caspi S; Cancer Research Center, Sheba Medical Center, Tel Aviv, Israel., Popović M; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Faganel Kotnik B; Department of Hematology and Oncology, University Children's Hospital, Ljubljana, Slovenia., Wood MD; Department of Pathology, Oregon Health & Science University, Portland, Oregon., Baird L; Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon., Davare MA; Department of Pediatrics, Oregon Health & Science University, Portland, Oregon., Solomon DA; Department of Pathology, University of California, San Francisco, California.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, California., Olsen TK; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden., Brandal P; Department of Oncology, Oslo University Hospital, Oslo, Norway., Farrell M; Department of Histopathology, Beaumont Hospital, Dublin, Ireland., Cryan JB; Department of Histopathology, Beaumont Hospital, Dublin, Ireland., Capra M; Paediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland., Karremann M; Department of Pediatrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Schittenhelm J; Institute of Pathology and Neuropathology, University Hospital Tübingen, Germany., Schuhmann MU; Department of Neurosurgery, University Hospital Tübingen, Germany., Ebinger M; Department of Pediatric Hematology and Oncology, University Hospital Tübingen, Germany., Dinjens WNM; Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands., Kerl K; Department of Pediatric Hematology and Oncology, University Hospital Muenster, Germany., Hettmer S; Department of Pediatric Hematology and Oncology, University Hospital Freiburg, Germany., Pietsch T; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Andreiuolo F; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Driever PH; Department of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany., Korshunov A; Department of Neuropathology, University Hospital Heidelberg, Germany., Hiddingh L; German Cancer Research Center (DKFZ), Heidelberg, Germany., Worst BC; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Sturm D; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Zuckermann M; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Witt O; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Bloom T; BRAIN UK, University of Southampton, Southampton, United Kingdom., Mitchell C; BRAIN UK, University of Southampton, Southampton, United Kingdom., Miele E; Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Colafati GS; Oncological Neuroradiology Unit, Department of Diagnostic Imaging, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Diomedi-Camassei F; Department of Laboratories - Pathology Unit, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Bailey S; Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom., Moore AS; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.; Oncology Service, Queensland Children's Hospital, Brisbane, Australia.; Child Health Research Centre, The University of Queensland, South Brisbane, Australia., Hassall TEG; Oncology Service, Queensland Children's Hospital, Brisbane, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia., Lowis SP; Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom., Tsoli M; Children's Cancer Institute, University of New South Wales, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia., Cowley MJ; Children's Cancer Institute, University of New South Wales, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia., Ziegler DS; Children's Cancer Institute, University of New South Wales, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia., Karajannis MA; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York., Aquilina K; Department of Neurosurgery, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom., Hargrave DR; Department of Paediatric Oncology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom., Carceller F; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.; Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom., Marshall LV; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.; Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom., von Deimling A; Department of Neuropathology, University Hospital Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Centre Göttingen, Germany., Pfister SM; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Sahm F; Department of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Baker SJ; Department of Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee., Mastronuzzi A; Neuro-oncology Unit, Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Carai A; Oncological Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Vinci M; Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Capper D; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Popov S; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.; Department of Pathology, University of Wales Hospital NHS Trust, Cardiff, United Kingdom., Ellison DW; Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org., Jacques TS; UCL Great Ormond Street Institute of Child Health, London, United Kingdom. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org., Jones DTW; German Cancer Research Center (DKFZ), Heidelberg, Germany. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Jones C; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.

Publikováno v: Cancer discovery [Cancer Discov] 2020 Jul; Vol. 10 (7), pp. 942-963. Date of Electronic Publication: 2020 Apr 01.