Mécanismes immunologiques impliqués dans la perte des mélanocytes au cours du vitiligo

Autor: Boukhedouni, Nesrine

Le vitiligo est une dermatose inflammatoire caractérisée par une perte progressive des mélanocytes de la lame basale de l’épiderme. Cette pathologie reste à ce jour orpheline de traitement efficace. Toutefois, les mécanismes qui sont liés à

Externí odkaz: http://www.theses.fr/2018BORD0300

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

Autor: BOUKHEDOUNI, Nesrine, Martins, Christina, Darrigade, Anne-Sophie, Drullion, Claire, RAMBERT, Jérôme, Barrault, Christine, Garnier, Julien, JACQUEMIN, Clement, THIOLAT, Denis, LUCCHESE, Fabienne, MOREL, Franck, Ezzedine, Khaled, Taieb, Alain, Bernard, François-Xavier, Seneschal, Julien, boniface, katia, Boniface1, Katia

Publikováno v: JCI Insight
JCI Insight, American Society for Clinical Investigation, 2020, 5 (11), pp.e133772. ⟨10.1172/jci.insight.133772⟩

International audience; Loss of melanocytes is the pathological hallmark of vitiligo, a chronic inflammatory skin depigmenting disorder induced by exaggerated immune response, including autoreactive CD8 T cells producing high levels of type 1 cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fa109c21cf4109a894aeed428daf050c
http://hdl.handle.net/20.500.12278/123881

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo.

Autor: Boukhedouni N; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Martins C; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Darrigade AS; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France.; Department of Dermatology and Pediatric Dermatology and National Reference Center for Rare Skin Disorders, Hôpital Saint-André, Bordeaux, France., Drullion C; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Rambert J; AquiDerm, University of Bordeaux, Bordeaux, France., Barrault C; Bioalternatives, Gençay, France., Garnier J; Bioalternatives, Gençay, France., Jacquemin C; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Thiolat D; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Lucchese F; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France., Morel F; Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France., Ezzedine K; Department of Dermatology, Assistance Publique-Hôpitaux de Paris, Hôpital Henri-Mondor, Créteil, France., Taieb A; Department of Dermatology and Pediatric Dermatology and National Reference Center for Rare Skin Disorders, Hôpital Saint-André, Bordeaux, France., Bernard FX; Bioalternatives, Gençay, France., Seneschal J; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France.; Department of Dermatology and Pediatric Dermatology and National Reference Center for Rare Skin Disorders, Hôpital Saint-André, Bordeaux, France., Boniface K; INSERM U1035, Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC), Immunodermatology ATIP-AVENIR, University of Bordeaux, FHU ACRONIM, Bordeaux, France.

Publikováno v: JCI insight [JCI Insight] 2020 Jun 04; Vol. 5 (11). Date of Electronic Publication: 2020 Jun 04.