piRNAs are regulators of metabolic reprogramming in stem cells

Autor: Patricia Rojas-Ríos, Aymeric Chartier, Camille Enjolras, Julie Cremaschi, Céline Garret, Adel Boughlita, Anne Ramat, Martine Simonelig

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Stem cells preferentially use glycolysis instead of oxidative phosphorylation and this metabolic rewiring plays an instructive role in their fate; however, the underlying molecular mechanisms remain largely unexplored. PIWI-interacting RNAs

Externí odkaz: https://doaj.org/article/bbc17df18fd24e56bfe9896dd13c6420

Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

Autor: Jean Nakhle, Khattar Khattar, Tülin Özkan, Adel Boughlita, Daouda Abba Moussa, Amelie Darlix, Frédérique Lorcy, Valérie RIGAU, Luc BAUCHET, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Floriant Bellvert, Laurent Turchi, Thierry Virolle, Jean-Philippe Hugnot, Nicolas Buisine, Mireille Galloni, Valerie Dardalhon, Anne-Marie Rodriguez, Marie-Luce Vignais

Publikováno v: Cancer Research Communications
Cancer Research Communications, 2023, 3 (6), pp.1041-1056. ⟨10.1158/2767-9764.CRC-23-0144⟩
Cancer Research Communications, 2023, 3, pp.1041-1056. ⟨10.1158/2767-9764.crc-23-0144⟩

International audience; Glioblastomas (GBM) are heterogeneous tumors with high metabolic plasticity. Their poor prognosis is linked to the presence of glioblastoma stem cells (GSC), which support resistance to therapy, notably to temozolomide (TMZ).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82ca59d992aa68ebf144b2b728720ed
https://hal.science/hal-04154698

Supplementary Materials and Methods from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

TMZ dose-response assay Caspase-GloⓇ 3/7 assay Cytotox assay Extracellular Flux Assays Cell Proliferation Western Blot Flow Cytometry Metabolite usage Mitoplates Mass Spectrometry Quantification 13C stable isotope tracing experiments Preparation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5721f3708ee485a20a9e29d39d09e8b7
https://doi.org/10.1158/2767-9764.23192200.v1

Data from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

Glioblastomas (GBM) are heterogeneous tumors with high metabolic plasticity. Their poor prognosis is linked to the presence of glioblastoma stem cells (GSCs), which support resistance to therapy, notably to temozolomide (TMZ). Mesenchymal stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3920829ce074ee71aeddfb94bb7003f0
https://doi.org/10.1158/2767-9764.c.6664816.v1

The Repercussions Of The Corona Pandemic And The Need To Improve The Health System In Algeria

Autor: Soltane Karima, Boughlita Ilhem

Publikováno v: مجلة البشائر الاقتصادية, Vol 7, Iss 2, Pp 910-924 (2021)

The study aims at highlighting the reality of the Algerian health system under the Corona pandemic by referring to the most important latter is imbalances that’s suffering from and its main causes, as well as to the most important measures and deci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::a7cfda4c376dce089470d90f49d83690
https://www.asjp.cerist.dz/en/downArticle/196/7/2/161133