piRNAs are regulators of metabolic reprogramming in stem cells.

Autor: Rojas-Ríos P; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain., Chartier A; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Enjolras C; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Cremaschi J; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Garret C; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Boughlita A; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Ramat A; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France., Simonelig M; Institute of Human Genetics, Université de Montpellier, CNRS, Montpellier, France. Martine.Simonelig@igh.cnrs.fr.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8405. Date of Electronic Publication: 2024 Sep 27.

Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

Autor: Jean Nakhle, Khattar Khattar, Tülin Özkan, Adel Boughlita, Daouda Abba Moussa, Amelie Darlix, Frédérique Lorcy, Valérie RIGAU, Luc BAUCHET, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Floriant Bellvert, Laurent Turchi, Thierry Virolle, Jean-Philippe Hugnot, Nicolas Buisine, Mireille Galloni, Valerie Dardalhon, Anne-Marie Rodriguez, Marie-Luce Vignais

Publikováno v: Cancer Research Communications
Cancer Research Communications, 2023, 3 (6), pp.1041-1056. ⟨10.1158/2767-9764.CRC-23-0144⟩
Cancer Research Communications, 2023, 3, pp.1041-1056. ⟨10.1158/2767-9764.crc-23-0144⟩

International audience; Glioblastomas (GBM) are heterogeneous tumors with high metabolic plasticity. Their poor prognosis is linked to the presence of glioblastoma stem cells (GSC), which support resistance to therapy, notably to temozolomide (TMZ).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82ca59d992aa68ebf144b2b728720ed
https://hal.science/hal-04154698

Supplementary Materials and Methods from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

TMZ dose-response assay Caspase-GloⓇ 3/7 assay Cytotox assay Extracellular Flux Assays Cell Proliferation Western Blot Flow Cytometry Metabolite usage Mitoplates Mass Spectrometry Quantification 13C stable isotope tracing experiments Preparation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5721f3708ee485a20a9e29d39d09e8b7
https://doi.org/10.1158/2767-9764.23192200.v1

Data from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

Glioblastomas (GBM) are heterogeneous tumors with high metabolic plasticity. Their poor prognosis is linked to the presence of glioblastoma stem cells (GSCs), which support resistance to therapy, notably to temozolomide (TMZ). Mesenchymal stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3920829ce074ee71aeddfb94bb7003f0
https://doi.org/10.1158/2767-9764.c.6664816.v1

Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring.

Autor: Nakhle J; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France.; Institute of Molecular Genetics of Montpellier, University of Montpellier, CNRS, Montpellier, France.; RESTORE Research Center, University of Toulouse, INSERM 1301, CNRS 5070, EFS, ENVT, Toulouse, France., Khattar K; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France., Özkan T; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France.; Faculty of Medicine, Department of Medical Biology, University of Ankara, Ankara, Turkey., Boughlita A; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France., Abba Moussa D; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France., Darlix A; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.; Department of Medical Oncology, Institut Régional du Cancer de Montpellier (ICM), University of Montpellier, Montpellier, France., Lorcy F; Department of Pathology and Oncobiology, Hôpital Gui de Chauliac, Montpellier, France.; The Center of the Biological Resource Center of University Hospital Center of Montpellier (BRC), Montpellier, France., Rigau V; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.; Department of Pathology and Oncobiology, Hôpital Gui de Chauliac, Montpellier, France.; The Center of the Biological Resource Center of University Hospital Center of Montpellier (BRC), Montpellier, France., Bauchet L; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.; Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier, France., Gerbal-Chaloin S; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France., Daujat-Chavanieu M; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France., Bellvert F; Toulouse Biotechnology Institute, University of Toulouse, CNRS, INRA, INSA, Toulouse, France.; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France., Turchi L; Université Côte D'Azur, CNRS, INSERM, Institut de Biologie Valrose, Team INSERM, 'Cancer Stem Cell Plasticity and Functional Intra-tumor Heterogeneity', Nice, France., Virolle T; Université Côte D'Azur, CNRS, INSERM, Institut de Biologie Valrose, Team INSERM, 'Cancer Stem Cell Plasticity and Functional Intra-tumor Heterogeneity', Nice, France., Hugnot JP; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France., Buisine N; UMR7221 Physiologie Moléculaire et Adaptation, CNRS, Muséum National d'Histoire Naturelle, Paris, France., Galloni M; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France., Dardalhon V; Institute of Molecular Genetics of Montpellier, University of Montpellier, CNRS, Montpellier, France., Rodriguez AM; Sorbonne Université, Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8256, INSERM ERL U1164, Biological Adaptation and Ageing, Paris, France., Vignais ML; Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France.

Publikováno v: Cancer research communications [Cancer Res Commun] 2023 Jun 14; Vol. 3 (6), pp. 1041-1056. Date of Electronic Publication: 2023 Jun 14 (Print Publication: 2023).