Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Boudewijn Burgering"'
Autor:
Maojie Wang, Bin Tang, Huanjie Huang, Xiaodong Wu, Hao Deng, Haiming Chen, Liyan Mei, Xiumin Chen, Boudewijn Burgering, Chuanjian Lu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Hyperplasia of epidermal keratinocytes that depend on glycolysis is a new hallmark of psoriasis pathogenesis. Our previous studies demonstrated that PSORI-CM02 could halt the pathological progression of psoriasis by targeting inflammatory response an
Externí odkaz:
https://doaj.org/article/5392aaa5eeaa4181a7fb0acb98f4b9dc
Autor:
Fangrong Zhang, Jakob Kerbl-Knapp, Maria J. Rodriguez Colman, Andreas Meinitzer, Therese Macher, Nemanja Vujić, Sandra Fasching, Evelyne Jany-Luig, Melanie Korbelius, Katharina B. Kuentzel, Maximilian Mack, Alena Akhmetshina, Anita Pirchheim, Margret Paar, Beate Rinner, Gerd Hörl, Ernst Steyrer, Ulrich Stelzl, Boudewijn Burgering, Tobias Eisenberg, Brigitte Pertschy, Dagmar Kratky, Tobias Madl
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 2, Pp 100016- (2021)
Summary: Quantitative information about the levels and dynamics of post-translational modifications (PTMs) is critical for an understanding of cellular functions. Protein arginine methylation (ArgMet) is an important subclass of PTMs and is involved
Externí odkaz:
https://doaj.org/article/6d74bd3fefba487aa0dcd5a2f0f8bbda
Autor:
Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1550-1566 (2018)
Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic
Externí odkaz:
https://doaj.org/article/cdb33609859447d8bd04980364f7430f
Autor:
Vincent Runtuwene, Mark van Eekelen, John Overvoorde, Holger Rehmann, Helger G. Yntema, Willy M. Nillesen, Arie van Haeringen, Ineke van der Burgt, Boudewijn Burgering, Jeroen den Hertog
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 3, Pp 393-399 (2011)
SUMMARY Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated with dysregulation of the Ras–mitogen-activated-protein-kinase
Externí odkaz:
https://doaj.org/article/917ce76435664510945a2a7b3336049e
Autor:
Diana Putavet, Marjolein Baar, Tao Shi, Johannes Lehmann, Tim Leyten, Esmee Bouma, Antoine Khalil, Harm-Jan Vos, Boudewijn Burgering, Tobias Dansen, Patrick Derksen, Peter de Keizer
Publikováno v:
Cancer Research. 82:P1-19
Metastatic breast cancer is the second most common cause of cancer-related death in women. Triple Negative Breast Cancer (TNBC) has tan especially poor prognosis partly due to these tumors lacking relevant molecular targets. The most commonly mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43e61a3dd25f54301dc4edc3475cabf
https://doi.org/10.1158/1538-7445.sabcs21-p1-19-02
https://doi.org/10.1158/1538-7445.sabcs21-p1-19-02
Autor:
Magdalena Harakalova, Jiayi Pei, Renee Maas, Karen Gaar-Humphreys, Johannes Gho, Emilia Nagyova, Christian Snijders Blok, Iris van Adrichem, René van Es, Shahrzad Sepehrkhouy, Dries Feyen, Noortje van den Dungen, Nico Lansu, Jorg Calis, Niels van der Kaaij, Nicolaas de Jonge, Linda van Laake, Anneline ter Riele, Manon Huibers, Roel de Weger, Marianne C. Verhaar, J. Peter van Tintelen, Frederic Vaz, Boudewijn Burgering, Alain van Mil, Jan Buikema, Aryan Vink, Ioannis Karakikes, Mark Mercola, Pieter AFM Doevendans, Joost Sluijter, Frank van Steenbeek, Caroline Cheng, Michal Mokry, Folkert Asselbergs
Carriers of the R14del pathogenic variant in the phospholamban (PLN) gene develop severe cardiomyopathy with extracellular adipocyte infiltration and intracellular cardiomyocyte mitochondrial disturbances. However, the basis of this metabolic dysregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bd1ee7c44ee4d91104e81530e9bfbfa
https://doi.org/10.21203/rs.3.rs-1902254/v1
https://doi.org/10.21203/rs.3.rs-1902254/v1
Autor:
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew Ramstead, Sophia M. Hochrein, HarmJan Vos, Geert Geeven, Adeolu Adegoke, Anna Hoekstra, Robert van Es, José Ramos Pittol, Sebastiaan Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin Anderson, Ryan O'Connell, Martin Vaeth, John Ussher, Boudewijn Burgering, Paul Coffer
Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that generation of extra-mitochondrial pyruva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b71b2a137c6e61ad219ab6d4149ac04
https://doi.org/10.21203/rs.3.rs-1324599/v1
https://doi.org/10.21203/rs.3.rs-1324599/v1
Autor:
Wybe J. M. van der Kemp, Maria T. Grinde, Jon O. Malvik, Hanneke W. M. van Laarhoven, Jeanine J. Prompers, Dennis W. J. Klomp, Boudewijn Burgering, Tone Frost Bathen, Siver Andreas Moestue
Publikováno v:
NMR in Biomedicine. John Wiley and Sons Ltd
NMR in Biomedicine
e4882
van der Kemp, W J M, Grinde, M T, Malvik, J O, van Laarhoven, H W M, Prompers, J J, Klomp, D W J, Burgering, B, Bathen, T F & Moestue, S A 2022, ' Metabolic profiling of colorectal cancer organoids : A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts ', NMR in Biomedicine . https://doi.org/10.1002/nbm.4882
NMR in Biomedicine
e4882
van der Kemp, W J M, Grinde, M T, Malvik, J O, van Laarhoven, H W M, Prompers, J J, Klomp, D W J, Burgering, B, Bathen, T F & Moestue, S A 2022, ' Metabolic profiling of colorectal cancer organoids : A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts ', NMR in Biomedicine . https://doi.org/10.1002/nbm.4882
Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological structure and organizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a46e35c5d34de00400391b22320451b
https://research.vumc.nl/en/publications/094bff02-25ee-4dbe-8979-7839dbe2511b
https://research.vumc.nl/en/publications/094bff02-25ee-4dbe-8979-7839dbe2511b
Autor:
Marlies Ludikhuize, Sira Gevers, Nguyen Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin Stigter, Jarno Drost, Hans Clevers, Boudewijn Burgering, Maria Rodríguez Colman
5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), however response rates in patients are limited to 50%. Unexpectedly, the molecular mechanisms by which 5-FU ultimately induces toxicity remain debated, limiting the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b473c13f15b7a7f6117bf5b784439ef
https://doi.org/10.21203/rs.3.rs-1054076/v1
https://doi.org/10.21203/rs.3.rs-1054076/v1
Autor:
Bart van der Hee, Myrthe Gilbert, Ineke Heikamp-de Jong, Merlijn van Gaal, Boudewijn Burgering, Walter Gerrits, Jerry Wells, Hauke Smidt
Publikováno v:
Animal - science proceedings. 13:203
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1087478526902b319617e160ce82455
https://doi.org/10.1016/j.anscip.2022.03.351
https://doi.org/10.1016/j.anscip.2022.03.351