Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection.

Autor: Simmons SR; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Herring SE; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Tchalla EYI; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Lenhard AP; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA. Elsaboug@buffalo.edu.

Publikováno v: Immunity & ageing : I & A [Immun Ageing] 2024 Jun 05; Vol. 21 (1), pp. 34. Date of Electronic Publication: 2024 Jun 05.

The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae .

Autor: Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Herring S; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Lenhard A; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Wheeler JR; Department of Pathology, Stanford University, Stanford, California, USA., Aswad F; BIOAGE Labs Inc., Richmond, California, USA., Klumpp K; BIOAGE Labs Inc., Richmond, California, USA., Rebo J; BIOAGE Labs Inc., Richmond, California, USA., Wang Y; BIOAGE Labs Inc., Richmond, California, USA., Wilhelmsen K; BIOAGE Labs Inc., Richmond, California, USA., Fortney K; BIOAGE Labs Inc., Richmond, California, USA., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA.

Publikováno v: Infection and immunity [Infect Immun] 2024 May 07; Vol. 92 (5), pp. e0052223. Date of Electronic Publication: 2024 Apr 17.

Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling.

Autor: Herring SE; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, United States of America., Mao S; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, United States of America., Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, United States of America., Tchalla EYI; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, United States of America., Kramer JM; Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, United States of America., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Nov 14; Vol. 18 (11), pp. e1010700. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).

Editorial: Transmission, colonization, and molecular pathogenesis of pneumococcus.

Autor: Vidal JE; Center for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, United States., Wu X; Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wu K; Department of Laboratory Medicine, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China., Bai G; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, United States., Hammerschmidt S; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 13; Vol. 12, pp. 1028047. Date of Electronic Publication: 2022 Sep 13 (Print Publication: 2022).

Transcriptome Profiling Reveals CD73 and Age-Driven Changes in Neutrophil Responses against Streptococcus pneumoniae.

Autor: Bhalla M; Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA., Heinzinger LR; Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA., Morenikeji OB; Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technologygrid.262613.2, Rochester, New York, USA.; Division of Biological and Health Sciences, University of Pittsburgh-Bradford, Bradford, Pennsylvania, USA., Marzullo B; Department of Biochemistry and Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, New York, USA., Thomas BN; Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technologygrid.262613.2, Rochester, New York, USA., Bou Ghanem EN; Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA.

Publikováno v: Infection and immunity [Infect Immun] 2021 Oct 15; Vol. 89 (11), pp. e0025821. Date of Electronic Publication: 2021 Jul 26.