Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection.

Autor: Simmons SR; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Herring SE; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Tchalla EYI; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Lenhard AP; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA. Elsaboug@buffalo.edu.

Publikováno v: Immunity & ageing : I & A [Immun Ageing] 2024 Jun 05; Vol. 21 (1), pp. 34. Date of Electronic Publication: 2024 Jun 05.

The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae .

Autor: Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Herring S; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Lenhard A; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA., Wheeler JR; Department of Pathology, Stanford University, Stanford, California, USA., Aswad F; BIOAGE Labs Inc., Richmond, California, USA., Klumpp K; BIOAGE Labs Inc., Richmond, California, USA., Rebo J; BIOAGE Labs Inc., Richmond, California, USA., Wang Y; BIOAGE Labs Inc., Richmond, California, USA., Wilhelmsen K; BIOAGE Labs Inc., Richmond, California, USA., Fortney K; BIOAGE Labs Inc., Richmond, California, USA., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, New York, USA.

Publikováno v: Infection and immunity [Infect Immun] 2024 May 07; Vol. 92 (5), pp. e0052223. Date of Electronic Publication: 2024 Apr 17.

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness.

Autor: Lenhard A; Department of Microbiology and Immunology, University at Buffalo School of Medicine., Joma BH; Department of Molecular Biology and Microbiology, Tufts University School of Medicine; Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences., Siwapornchai N; Department of Molecular Biology and Microbiology, Tufts University School of Medicine., Hakansson AP; Department of Translational Medicine, Lund University., Leong JM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine; Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance, Tufts University., Bou Ghanem EN; Department of Microbiology and Immunology, University at Buffalo School of Medicine; elsaboug@buffalo.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2022 Sep 28 (187). Date of Electronic Publication: 2022 Sep 28.

The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts.

Autor: Simmons SR; Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, NY, United States., Tchalla EYI; Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, NY, United States., Bhalla M; Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, NY, United States., Bou Ghanem EN; Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, NY, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Mar 23; Vol. 12, pp. 849224. Date of Electronic Publication: 2022 Mar 23 (Print Publication: 2022).

A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age.

Autor: Joma BH; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.; Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, Massachusetts, USA., Siwapornchai N; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA., Vanguri VK; UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Shrestha A; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA., Roggensack SE; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.; Graduate Program in Molecular Microbiology, Tufts Graduate School of Biomedical Sciences, Boston, Massachusetts, USA., Davidson BA; Department of Anesthesiology, University at Buffalo School of Medicine, Buffalo, New York, USA., Tai AK; Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA., Hakansson AP; Department of Translational Medicine, Lund University, Malmö, Sweden., Meydani SN; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA., Leong JM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.; Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance at Tufts (Levy CIMAR), Boston, Massachusetts, USA., Bou Ghanem EN; Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA.

Publikováno v: Infection and immunity [Infect Immun] 2021 Jul 15; Vol. 89 (8), pp. e0047120. Date of Electronic Publication: 2021 Jul 15.