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pro vyhledávání: '"Bottomley AL"'
The emergence of multi-drug resistant bacteria has increased the need for novel antibiotics to help overcome what may be considered the greatest threat to modern medicine. Here we report the synthesis of fifteen novel 3,5-diaryl-1H- pyrazoles obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::db99bbcc0138e011d8c60d9a406bd42d
https://hdl.handle.net/10453/152712
https://hdl.handle.net/10453/152712
Methicillin-resistant Staphylococcus aureus (MRSA) has proven to be an imminent threat to public health, intensifying the need for novel therapeutics. Previous evidence suggests that cannabinoids harbour potent antibacterial activity. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::5f215bf2ee618ba4b2a49d493682c108
https://hdl.handle.net/10453/142611
https://hdl.handle.net/10453/142611
Autor:
Bouzo D, Cokcetin NN, Li L, Ballerin G, Bottomley AL, Lazenby J, Whitchurch CB, Paulsen IT, Hassan KA, Harry EJ
Manuka honey has broad-spectrum antimicrobial activity, and unlike traditional antibiotics, resistance to its killing effects has not been reported. However, its mechanism of action remains unclear. Here, we investigated the mechanism of action of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::03ecfa55bbc8ab240613f7743a9eda68
https://hdl.handle.net/10453/143840
https://hdl.handle.net/10453/143840
Autor:
Bouzo D, Cokcetin NN, Li L, Ballerin G, Bottomley AL, Lazenby J, Whitchurch CB, Paulsen IT, Hassan KA, Harry EJ
Manuka honey has broad-spectrum antimicrobial activity and unlike traditional antibiotics, resistance to its killing effects has not been reported. However, its mechanism of action remains unclear. Here we investigated the mechanism of action of manu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::dfedc85f5acb0c0bff493c43e65053a6
https://hdl.handle.net/10453/147050
https://hdl.handle.net/10453/147050
Autor:
Valentin, E, Bottomley, AL, Chilambi, GS, Harry, EJ, Amal, R, Sotiriou, GA, Rice, SA, Gunawan, C
The past decade has seen the incorporation of antimicrobial nanosilver (NAg) into medical devices, and, increasingly, in everyday 'antibacterial' products. With the continued rise of antibiotic resistant bacteria, there are concerns that these priori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::f1f87256ab865181067687df81b0d2da
https://hdl.handle.net/10453/142098
https://hdl.handle.net/10453/142098
BACKGROUND:Uropathogenic Escherichia coli (UPEC) are a major cause of urinary tract infection (UTI), one of the most common infectious diseases in humans. UPEC are increasingly associated with resistance to multiple antibiotics. This includes resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::d47431c4ebcc71328924abdc41eeefde
https://hdl.handle.net/10453/142095
https://hdl.handle.net/10453/142095
© 2019 CSIRO. The bacterial cell division protein FtsZ is conserved in most bacteria and essential for viability. There have been concerted efforts in developing inhibitors that target FtsZ as potential antibiotics. Key to this is an in-depth unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::3c49981dfb61e7f4181db0b27631afe1
https://hdl.handle.net/10453/129687
https://hdl.handle.net/10453/129687
© 2017 The Royal Society of Chemistry. Condensation studies of chromosomal DNA in E. coli with a tetranuclear ruthenium complex are carried out and images obtained with wide-field fluorescence microscopy. Remarkably different condensate morphologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::4b01d2022f40cfad58a6459a048e6b10
https://hdl.handle.net/10453/110588
https://hdl.handle.net/10453/110588
Autor:
Li, F, Harry, EJ, Bottomley, AL, Edstein, MD, Birrell, GW, Woodward, CE, Keene, FR, Collins, JG
Wide-field fluorescence microscopy at high magnification was used to study the intracellular binding site of Rubb16 in Escherichia coli. Upon incubation of E. coli cells at the minimum inhibitory concentration, Rubb 16 localised at ribosomes with no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::aed32a626c4dc7ff1c6087a379d33835
https://hdl.handle.net/10453/32290
https://hdl.handle.net/10453/32290