Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Bottelbergs A"'
Autor:
Ine Paesmans, Kristof Van Kolen, Marc Vandermeeren, Pei-Yu Shih, Dirk Wuyts, Fleur Boone, Sergio Garcia Sanchez, Karolien Grauwen, Filip Van Hauwermeiren, Nina Van Opdenbosch, Mohamed Lamkanfi, Geert van Loo, Astrid Bottelbergs
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundNeuroinflammation is widely recognized as a key factor in the pathogenesis of Alzheimer’s disease (AD), alongside ß-amyloid deposition and the formation of neurofibrillary tangles. The NLR family pyrin domain containing 3 (NLRP3) inflamm
Externí odkaz:
https://doaj.org/article/ce931bbf061143caa3b0692f21880bfb
Autor:
Xiaodi Yu, Rosalie E. Matico, Robyn Miller, Dhruv Chauhan, Bertrand Van Schoubroeck, Karolien Grauwen, Javier Suarez, Beth Pietrak, Nandan Haloi, Yanting Yin, Gary John Tresadern, Laura Perez-Benito, Erik Lindahl, Astrid Bottelbergs, Daniel Oehlrich, Nina Van Opdenbosch, Sujata Sharma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical intracellular inflammasome sensor and an important clinical target against inflammation-driven human diseases. Recent studies have elucidated its t
Externí odkaz:
https://doaj.org/article/7f229443efb44bc9b6f041484b3699ef
Autor:
Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito, Maude Jans, Fleur Boone, Charysse Vandendriessche, Ine Paesmans, Hervé Maurin, Roosmarijn E. Vandenbroucke, Esther Hoste, Sofie Voet, Isabelle Scheyltjens, Benjamin Pavie, Saskia Lippens, Marius Schwabenland, Marco Prinz, Takaomi Saido, Astrid Bottelbergs, Kiavash Movahedi, Mohamed Lamkanfi, Geert van Loo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder affecting memory and cognition. The disease is accompanied by an abnormal deposition of ß-amyloid plaques in the brain that contributes to neurodegeneration and is kn
Externí odkaz:
https://doaj.org/article/9176fde1a9644a96960b77fefeca6640
Autor:
Bottelbergs Astrid, Verheijden Simon, Van Veldhoven Paul P, Just Wilhelm, Devos Rita, Baes Myriam
Publikováno v:
Journal of Neuroinflammation, Vol 9, Iss 1, p 61 (2012)
Abstract Background Mice with peroxisome deficiency in neural cells (Nestin-Pex5−/−) develop a neurodegenerative phenotype leading to motor and cognitive disabilities and early death. Major pathologies at the end stage of disease include severe d
Externí odkaz:
https://doaj.org/article/89b795e6f40641d7b4123d5a3eb55f69
Akademický článek
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Autor:
Janssens, Jonathan, Hermans, Bart, Vandermeeren, Marc, Barale-Thomas, Erio, Borgers, Marianne, Willems, Roland, Meulders, Greet, Wintmolders, Cindy, Van den Bulck, Dries, Bottelbergs, Astrid, Ver Donck, Luc, Larsen, Peter, Moechars, Dieder, Edwards, Wilson, Mercken, Marc, Van Broeck, Bianca
Publikováno v:
In Neurobiology of Disease July 2021 154
Autor:
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachter
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenes
Externí odkaz:
https://doaj.org/article/852fe2a6f7d24a1d8306a8d889edd584
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts, Astrid Bottelbergs
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1597-1607 (2020)
The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery.
Externí odkaz:
https://doaj.org/article/3a2c73fb65e34179bd76465154cdf0e3