Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections

Autor: Subramaniam, Nirojah, Bottek, Jenny, Thiebes, Stephanie, Zec, Kristina, Kudla, Matthias, Soun, Camille, de Dios Panal, Elena, Lill, Julia K., Pfennig, Aaron, Herrmann, Ralf, Bruderek, Kirsten, Rahmann, Sven, Brandau, Sven, Johansson, Patricia, Reinhardt, Hans Christian, Dürig, Jan, Seiffert, Martina, Bracht, Thilo, Sitek, Barbara, Engel, Daniel Robert ^*

Publikováno v: In Blood Advances 9 March 2021 5(5):1259-1272

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Spatial proteomics revealed a CX₃CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder

Autor: Bottek, Jenny, Soun, Camille, Lill, Julia K., Dixit, Akanksha, Thiebes, Stephanie, Beerlage, Anna-Lena, Horstmann, Marius, Urbanek, Annett, Heuer, Heike, Uszkoreit, Julian, Eisenacher, Martin, Bracht, Thilo, Sitek, Barbara, Hoffmann, Franziska, Vijitha, Nirojah, von Eggeling, Ferdinand, Engel, Daniel Robert

The urothelium of the urinary bladder represents the first line of defense. However, uropathogenic E. coli (UPEC) damage the urothelium and cause acute bacterial infection. Here, we demonstrate the crosstalk between macrophages and the urothelium sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=unidue___bib::1aa22cff494188f8e603e6d0f1f4b39f
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85080115888

Frontline Science: Proliferation of Ly6C⁺ monocytes during urinary tract infections is regulated by IL‐6 trans‐signaling.

Autor: Dixit, Akanksha, Bottek, Jenny, Beerlage, Anna‐Lena, Schuettpelz, Jana, Thiebes, Stephanie, Brenzel, Alexandra, Garbers, Christoph, Rose‐John, Stefan, Mittrücker, Hans‐Willi, Squire, Anthony, Engel, Daniel R.

Publikováno v: Journal of Leukocyte Biology; Jan2018, Vol. 103 Issue 1, p13-22, 10p

Spatial proteomics revealed a CX 3 CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.

Autor: Bottek J; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Soun C; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Lill JK; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Dixit A; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Thiebes S; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Beerlage AL; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Horstmann M; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., Urbanek A; Leibniz Institute of Photonic Technology, 07743, Jena, Germany., Heuer H; Clinic for Endocrinology, University Hospital Essen, 45147, Essen, Germany., Uszkoreit J; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801, Bochum, Germany., Eisenacher M; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801, Bochum, Germany., Bracht T; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801, Bochum, Germany., Sitek B; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801, Bochum, Germany., Hoffmann F; Department of Otorhinolaryngology, Jena University Hospital, 07743, Jena, Germany., Vijitha N; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany., von Eggeling F; Department of Otorhinolaryngology, Jena University Hospital, 07743, Jena, Germany., Engel DR; Institute of Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, 45147, Essen, Germany. engel@immunodynamics.de.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2020 Jul; Vol. 13 (4), pp. 702-714. Date of Electronic Publication: 2020 Feb 28.