Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.

Autor: Dyck B; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Branstetter B; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Gharbaoui T; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Hudson AR; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Breitenbucher JG; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Gomez L; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Botrous I; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Marrone T; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Barido R; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Allerston CK; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Cedervall EP; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Xu R; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Sridhar V; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Barker R; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Aertgeerts K; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Schmelzer K; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Neul D; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Lee D; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Massari ME; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Andersen CB; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Sebring K; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Zhou X; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Petroski R; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Limberis J; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Augustin M; Proteros Biostructures GmbH , Bunsenstraße 7a, D-82152 Martinsried, Germany., Chun LE; Berylllium , 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States., Edwards TE; Berylllium , 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States., Peters M; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States., Tabatabaei A; Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Apr 27; Vol. 60 (8), pp. 3472-3483. Date of Electronic Publication: 2017 Apr 13.

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.

Autor: Li H; Pfizer Global Research & Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA 92121, United States. hui.li@ppdi.com, Hong Y, Nukui S, Lou J, Johnson S, Scales S, Botrous I, Tompkins E, Yin C, Zhou R, He M, Jensen J, Bouzida D, Alton G, Lafontaine J, Grant S

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jan 01; Vol. 21 (1), pp. 584-7. Date of Electronic Publication: 2010 Oct 13.