Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Botond Z. Igyártó"'
Autor:
Christopher H. Herbst, Aurélie Bouteau, Evelin J. Menykő, Zhen Qin, Ervin Gyenge, Qingtai Su, Vincent Cooper, Neil A. Mabbott, Botond Z. Igyártó
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109119- (2024)
Summary: In a previous report, keratinocytes were shown to share their gene expression profile with surrounding Langerhans cells (LCs), influencing LC biology. Here, we investigated whether transferred material could substitute for lost gene products
Externí odkaz:
https://doaj.org/article/e7eedd8056884e228fd575bccf9b35a0
Autor:
Botond Z. Igyártó, Zhen Qin
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as the basis of the most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these vaccines were deemed safe and effec
Externí odkaz:
https://doaj.org/article/4ae3d239544846dda625f7df74a33e69
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dendritic cells (DCs) are required for the initiation of the adaptive immune response. Their ability to acquire antigens in the periphery is a critical step in this process. DCs express a wide variety of adhesion molecules and possess an extremely fl
Externí odkaz:
https://doaj.org/article/1ca0f8a3d0274221bf19b951a5c60a8b
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101350- (2022)
Summary: We describe a protocol to study inflammatory responses triggered by the mRNA-lipid nanoparticle (LNP) vaccine formulations in skin, muscle, and lung and the adaptive immune responses induced in the draining lymph nodes. Here, we will present
Externí odkaz:
https://doaj.org/article/717063fbb1eb47c9b2dbb3f01df770c3
Autor:
Valentina Ceglia, Sandra Zurawski, Monica Montes, Mitchell Kroll, Aurélie Bouteau, Zhiqing Wang, Jerome Ellis, Botond Z. Igyártó, Yves Lévy, Gerard Zurawski
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
CD40 is a potent activating receptor expressed on antigen-presenting cells (APCs) of the immune system. CD40 regulates many aspects of B and T cell immunity via interaction with CD40L expressed on activated T cells. Targeting antigens to CD40 via ago
Externí odkaz:
https://doaj.org/article/15f7ca4c2a8e472e9f3e1cf473700acf
Autor:
Sonia Ndeupen, Zhen Qin, Sonya Jacobsen, Aurélie Bouteau, Henri Estanbouli, Botond Z. Igyártó
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103479- (2021)
Summary: Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. Clinical trials and ongoing vaccinations present with varying degrees of protection levels and side effe
Externí odkaz:
https://doaj.org/article/8c4e06d68ede410195a0440cfbbaaac1
Autor:
Botond Z. Igyártó
Publikováno v:
Microorganisms, Vol 10, Iss 7, p 1463 (2022)
This analysis piece will attempt to examine some of the critical pandemic-related measures implemented in the United States from an immunological perspective and pinpoint caveats that should have been considered before their implementation. I also di
Externí odkaz:
https://doaj.org/article/9e49cd572d5140bfbc01a1b3301647cf
DC Subsets Regulate Humoral Immune Responses by Supporting the Differentiation of Distinct Tfh Cells
Autor:
Aurélie Bouteau, Jérôme Kervevan, Qingtai Su, Sandra M. Zurawski, Vanessa Contreras, Nathalie Dereuddre-Bosquet, Roger Le Grand, Gerard Zurawski, Sylvain Cardinaud, Yves Levy, Botond Z. Igyártó
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
To determine the contribution of skin DC subsets in the regulation of humoral immunity, we used a well-characterized antigen targeting system to limit antigen availability and presentation to certain skin-derived DC subsets. Here we show that deliver
Externí odkaz:
https://doaj.org/article/717f073b5d9d43809959c3d18fcd4e73
Autor:
Botond Z. Igyártó, Monica Montes, Aurélie Bouteau, Zhiqing Wang, Yves Levy, Sandra Zurawski, Jerome Ellis, Valentina Ceglia, Gerard Zurawski
Publikováno v:
J Immunol
CD40 is a potent activating receptor within the TNFR family expressed on APCs of the immune system, and it regulates many aspects of B and T cell immunity via interaction with CD40 ligand (CD40L; CD154) expressed on the surface of activated T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157ed3b6374014ae9237bd0da54ceb86
https://doi.org/10.4049/jimmunol.2000704
https://doi.org/10.4049/jimmunol.2000704
Autor:
Sarah K. Whitley, Mushi Li, Sakeen W. Kashem, Toshiro Hirai, Botond Z. Igyártó, Kelley Knizner, Jonhan Ho, Laura K. Ferris, Casey T. Weaver, Daniel J. Cua, Mandy J. McGeachy, Daniel H. Kaplan
Publikováno v:
Science Immunology. 7
The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e2d3b84999d416b9f74700a391e0bd
https://doi.org/10.1126/sciimmunol.abq3254
https://doi.org/10.1126/sciimmunol.abq3254