Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Botond Z Igyarto"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010830 (2022)
Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, a
Externí odkaz:
https://doaj.org/article/11db572bc55d44cebfcb58ee26d61e2d
Autor:
Qingtai Su, Aurélie Bouteau, Jacob Cardenas, Balaji Uthra, Yuanyaun Wang, Cynthia Smitherman, Jinghua Gu, Botond Z Igyártó
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0223397 (2020)
Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, ver
Externí odkaz:
https://doaj.org/article/4fbb904bdc774c01a9670e235f6e6915
Autor:
Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Publikováno v:
Diabetes. 71:1735-1745
Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T-cell population. Hybrid peptides formed through transpeptidation within pancreatic β-cell lysosomes have been proposed as a new class of autoantigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d81436041a407da33f364527a2d091
https://doi.org/10.2337/db21-1069
https://doi.org/10.2337/db21-1069
Autor:
Matthew L. Bettini, Maria Bettini, Gerard Zurawski, Dean Tantin, Sandra Zurawski, Botond Z. Igyarto, Yuelin Kong, Jelena Perovanovic, Yong Lin
Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T cell population. Hybrid peptides formed through transpeptidation within pancreatic beta cell lysosomes have been proposed as a new class of autoantigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c73e554984f6a0206e94f2d5989de59
https://doi.org/10.2337/figshare.19799728.v1
https://doi.org/10.2337/figshare.19799728.v1
Autor:
Yong Lin, Yuelin Kong, Botond Z Igyarto, Gerard Zurawski, Sandra Zurawski, Maria Bettini, Matthew Bettini
Publikováno v:
The Journal of Immunology. 206:51.08-51.08
Type 1 Diabetes (T1D) is a T cell-mediated autoimmune disease characterized by the immune destruction of pancreatic β cells. The search for natural equivalents to the mimetopes that can stimulate diabetogenic T cell clones from the Non-Obese Diabeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f275f66c2a89842d236c00916d1cdb
https://doi.org/10.4049/jimmunol.206.supp.51.08
https://doi.org/10.4049/jimmunol.206.supp.51.08
Publikováno v:
The Journal of Immunology. 206:30.01-30.01
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against coronavirus disease in 2019 (COVID-19). Clinical trials and ongoing vaccinations present with very high protection levels w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed0d9b7acd386a9333a0d9be7bebb85
https://doi.org/10.4049/jimmunol.206.supp.30.01
https://doi.org/10.4049/jimmunol.206.supp.30.01
Autor:
Valentina Ceglia, Sandy Zurawski, Monica Montes, Aurelie Bouteau, Zhiqing Wang, Jerome Ellis, Mitchell Kroll, Botond Z Igyarto, Yves Levy, Gerard Zurawski
Publikováno v:
The Journal of Immunology. 204:167.2-167.2
Soluble CD40L and agonistic anti-CD40 monoclonal antibody are adjuvants used in vaccination settings. Vaccines based on anti-CD40 antibodies fused to HIV-1 antigens are in clinical development. Studies with current anti-CD40-based dendritic cell (DC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edf8ca7cb5781e0925c2e9c77a61b9a
https://doi.org/10.4049/jimmunol.204.supp.167.2
https://doi.org/10.4049/jimmunol.204.supp.167.2
Autor:
Sonia Ndeupen, Aurélie Bouteau, Christopher Herbst, Zhen Qin, Sonya Jacobsen, Nicholas E Powers, Zachary Hutchins, Drishya Kurup, Leila Zabihi Diba, Megan Watson, Holly Ramage, Botond Z Igyártó
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010255 (2022)
Nucleoside modified mRNA combined with Acuitas Therapeutics' lipid nanoparticles (LNPs) has been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later in humans with the SARS-CoV-2 vaccination. We recen
Externí odkaz:
https://doaj.org/article/f8eb0e3078144ef88f3868bb3e7f5caa
Autor:
Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z Igyártó, Yves Levy, Sylvain Cardinaud
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009749 (2021)
The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb). In mouse and non-hu
Externí odkaz:
https://doaj.org/article/d8ccad982f5d4146b6cb7179328b5e87