Transglutaminase 2 is associated with adverse colorectal cancer survival and represents a therapeutic target.

Autor: Malkomes P; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Lunger I; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany.; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt am Main, Germany., Oppermann E; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany., Lorenz J; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany., Faqar-Uz-Zaman SF; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany., Han J; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany., Bothur S; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt am Main, Germany., Ziegler P; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.; University Cancer Center (UCT), Frankfurt am Main, Germany., Bankov K; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.; University Cancer Center (UCT), Frankfurt am Main, Germany., Wild P; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.; University Cancer Center (UCT), Frankfurt am Main, Germany., Bechstein WO; Department for General, Visceral, Transplant and Thoracic Surgery, Goethe University, Frankfurt am Main, Germany., Rieger MA; Frankfurt Cancer Institute, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. m.rieger@em.uni-frankfurt.de.; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.; Cardio-Pulmonary-Institute, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.

Publikováno v: Cancer gene therapy [Cancer Gene Ther] 2023 Oct; Vol. 30 (10), pp. 1346-1354. Date of Electronic Publication: 2023 Jul 13.

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.

Autor: Malkomes P; Goethe University Hospital Frankfurt, Department of General, Visceral and Transplant Surgery, Frankfurt am Main, Germany., Lunger I; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Oppermann E; Goethe University Hospital Frankfurt, Department of General, Visceral and Transplant Surgery, Frankfurt am Main, Germany., Abou-El-Ardat K; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany.; German Cancer Consortium and German Cancer Research Center (DKFZ), Heidelberg, Germany., Oellerich T; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany.; German Cancer Consortium and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany., Günther S; Max Planck Institute for Heart and Lung Research, Department I Cardiac Development and Remodelling, Bad Nauheim, Germany., Canbulat C; Goethe University Hospital Frankfurt, Department of General, Visceral and Transplant Surgery, Frankfurt am Main, Germany., Bothur S; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Schnütgen F; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany.; German Cancer Consortium and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany., Yu W; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Wingert S; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Haetscher N; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Catapano C; Single Molecule Biophysics, Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Dietz MS; Single Molecule Biophysics, Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Heilemann M; Single Molecule Biophysics, Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Kvasnicka HM; Goethe University Frankfurt, Senckenberg Institute for Pathology, Frankfurt am Main, Germany., Holzer K; Goethe University Hospital Frankfurt, Department of General, Visceral and Transplant Surgery, Frankfurt am Main, Germany.; Philipps University of Marburg, Department of Visceral-, Thoracic- and Vascular Surgery, Marburg, Germany., Serve H; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany.; German Cancer Consortium and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Frankfurt am Main, Germany., Bechstein WO; Goethe University Hospital Frankfurt, Department of General, Visceral and Transplant Surgery, Frankfurt am Main, Germany., Rieger MA; Goethe University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.; German Cancer Consortium and German Cancer Research Center (DKFZ), Heidelberg, Germany. m.rieger@em.uni-frankfurt.de.; Frankfurt Cancer Institute, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.; Cardio-Pulmonary Institute, Frankfurt am Main, Germany. m.rieger@em.uni-frankfurt.de.

Publikováno v: Oncogene [Oncogene] 2021 Jun; Vol. 40 (25), pp. 4352-4367. Date of Electronic Publication: 2021 Jun 08.

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Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

Autor: Bhayadia R; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Krowiorz K; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Haetscher N; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Jammal R; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Emmrich S; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Obulkasim A; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Fiedler J; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Schwarzer A; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Rouhi A; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Heuser M; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Wingert S; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Bothur S; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Döhner K; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Mätzig T; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Ng M; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Reinhardt D; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Döhner H; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Zwaan CM; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., van den Heuvel Eibrink M; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Heckl D; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Fornerod M; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Thum T; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Humphries RK; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Rieger MA; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Kuchenbauer F; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom., Klusmann JH; Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2018 Apr 01; Vol. 36 (10), pp. 1007-1016. Date of Electronic Publication: 2018 Feb 12.

Pathogenetic Contributions and Therapeutic Implications of Transglutaminase 2 in Neurodegenerative Diseases.

Autor: Liu, Jun¹ (AUTHOR) jl2574@rwjms.rutgers.edu, Mouradian, M. Maral¹ (AUTHOR) m.mouradian@rutgers.edu

Publikováno v: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2364. 23p.