Safety and efficacy of tofacitinib for the treatment of patients with juvenile idiopathic arthritis: preliminary results of an open-label, long-term extension study.

Autor: Brunner HI; Division of Rheumatology and Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Hermine.brunner@cchmc.org., Akikusa JD; Paediatric Rheumatology Service, The Royal Children's Hospital, Parkville, Victoria, Australia., Al-Abadi E; Paediatric and Adolescent Rheumatology Service, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK., Bohnsack JF; Division of Allergy and Immunology, Primary Children's Hospital, Salt Lake City, Utah, USA., Boteanu AL; Rheumatology Service, Hospital Universitario Ramon y Cajal, Madrid, Spain., Chedeville G; Department of Pediatrics, Division of Rheumatology, McGill University Health Centre, Glen Site, Montreal, Quebec, Canada., Cuttica R; Paediatric Rheumatology, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina., De La Pena W; Pediatric Rheumatology, Loma Linda University Children's Hospital, Loma Linda, California, USA., Jung L; Department of Pediatrics, School of Medicine, George Washington University, Washington, District of Columbia, USA., Kasapcopur O; Department of Paediatric Rheumatology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey., Kobusinska K; Department of Paediatrics, Haematology, Oncology and Rheumatology, Wojewodzki Szpital Dzieciecy im J Brudzinskiego, Bydgoszcz, Poland., Schulert GS; Division of Rheumatology and Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Neiva C; Paediatric Rheumatology Network, Santa Casa de Misericórdia de Belo Horizonte, Minas Gerais, Brazil., Rivas-Chacon R; Division of Rheumatology, Nicklaus Children's Hospital, Miami, Florida, USA., Rizo Rodriguez JC; Centro de Alta Especialidad en Reumatología e Investigación del Potosí, SC, San Luis Potosí, Mexico., Vazquez-Del Mercado M; Clínica de Investigacion en Reumatologia y Obesidad, SC, Guadalajara, Mexico., Wagner-Weiner L; Pediatric Rheumatology, University of Chicago Medical Center, Chicago, Illinois, USA., Weiss JE; Pediatric Rheumatology, Hackensack University Medical Center, Hackensack, New Jersey, USA., Wouters C; Paediatric Rheumatology, Department of Paediatrics, UZ Leuven-Gasthuisberg, Leuven, Belgium., Posner H; Pfizer, New York, New York, USA., Wouters A; Pfizer, New York, New York, USA., Chang C; Pfizer, Groton, Connecticut, USA., White C; Pfizer, Walton Oaks, UK., Kanik K; Pfizer, Groton, Connecticut, USA., Liu S; Pfizer, Shanghai, China., Martini A; Paediatric Rheumatology, Department of Paediatrics, University of Genova, Genova, Italy., Lovell DJ; Division of Rheumatology and Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Ruperto N; Pediatric and Rheumatology Clinic, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2024 Oct 21; Vol. 83 (11), pp. 1561-1571. Date of Electronic Publication: 2024 Oct 21.

A child with targetoid facial papules and acral plaques.

Autor: de Nicolas-Ruanes B; Department of Dermatology, University Hospital Ramon y Cajal, Madrid, Spain., Torre-Castro J; Department of Dermatology, University Hospital Fundacion Jimenez Diaz, Madrid, Spain., Boteanu AL; Department of Rheumatology, University Hospital Ramon y Cajal, Madrid, Spain., Navarro-Cantero A; Department of Pathology, University Hospital Ramon y Cajal, Madrid, Spain., Perez-Garcia B; Department of Dermatology, University Hospital Ramon y Cajal, Madrid, Spain.

Publikováno v: Pediatric dermatology [Pediatr Dermatol] 2023 May-Jun; Vol. 40 (3), pp. 559-561.

Safety and efficacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial

Autor: Brunner, HI, Abud-Mendoza, C, Viola, DO, Penades, IC, Levy, D, Anton, J, Calderon, JE, Chasnyk, VG, Ferrandiz, MA, Keltsev, V, Gastanaga, MEP, Shishov, M, Boteanu, AL, Henrickson, M, Bass, D, Clark, K, Hammer, A, Ji, BN, Nino, A, Roth, DA, Struemper, H, Wang, ML, Martini, A, Lovell, D, Ruperto, N, Paediat Rheumatology, Pediat Rheumatology Collab

Publikováno v: ANNALS OF THE RHEUMATIC DISEASES
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Objectives This ongoing Phase-2, randomised, placebo-controlled, double-blind study evaluated the efficacy, safety and pharmacokinetics of intravenous belimumab in childhood-onset systemic lupus erythematosus (cSLE). Methods Patients (5 to 17 years)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::880d26366cc59083b5c155aff5d274b5
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=12570

Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial

Autor: Ruperto, Nicolino, Brunner, Hermine I, Synoverska, Olga, Ting, Tracy V, Mendoza, Carlos Abud, Spindler, Alberto, Vyzhga, Yulia, Marzan, Katherine, Grebenkina, Lyudmila, Tirosh, Irit, Imundo, Lisa, Jerath, Rita, Kingsbury, Daniel J, Sozeri, Betul, Vora, Sheetal S, Prahalad, Sampath, Zholobova, Elena, Butbul Aviel, Yonatan, Chasnyk, Vyacheslav, Lerman, Melissa, Nanda, Kabita, Schmeling, Heinrike, Tory, Heather, Uziel, Yosef, Viola, Diego O, Posner, Holly B, Kanik, Keith S, Wouters, Ann, Chang, Cheng, Zhang, Richard, Lazariciu, Irina, Hsu, Ming-Ann, Suehiro, Ricardo M, Martini, Alberto, Lovell, Daniel J, Cuttica, R, Akikusa, J, Chaitow, J, Wouters, C, Oliveira, S, Neiva, CLS, Santiago, M, Silva, CA, Terreri, MT, Magalhaes, C, De Souza, V, Bandeira, M, Chédeville, G, Houghton, K, Vazquez-Del Mercado, M, Rizo Rodriguez, J, Kobusinska, K, Alexeeva, E, Calvo Penades, I, Boteanu, AL, Kasapcopur, O, Poyrazoglu, MH, Erguven, M, Ozen, S, Al-Abadi, E, Bohnsack, J, Carrasco, R, Dare, J, Gottlieb, B, Wahezi, D, Jung, L, Klein-Gitelman, M, Zhang, Y, Wagner-Weiner, L, Tarvin, S, Vehe, RK, Chiraseveenuprapund, P, Rivas-Chacon, R, De La Pena, W, Sagcal-Gironella, ACP, Weiss, JE

Publikováno v: The Lancet; November-December 2021, Vol. 398 Issue: 10315 p1984-1996, 13p

A clinical prediction model for estimating the risk of developing uveitis in patients with juvenile idiopathic arthritis.

Autor: van Straalen JW; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands., Giancane G; Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Genoa, Italy., Amazrhar Y; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands., Tzaribachev N; Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany., Lazar C; Pediatrics, Spitalul Clinic de Urgenta pentru Copii, Cluj-Napoca, Romania., Uziel Y; Department of Pediatrics, Pediatric Rheumatology Unit, Meir Medical Center, Kfar Saba, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Telcharova-Mihaylovska A; Department of Paediatric Rheumatology, University Children's Hospital, Sofia, Bulgaria., Len CA; Pediatrics Department, Universidade Federal de São Paulo, Sao Paulo, Brazil., Miniaci A; Salute della Donna, del Bambino e dell'Adolescente-Padiglione 16 Ambulatorio di reumatologia, Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Italy., Boteanu AL; Pediatric Rheumatology Unit, University Hospital Ramón y Cajal, Madrid, Spain., Filocamo G; Pediatric Rheumatology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy., Mastri MV; Unidad de Reumatologia, Hospital Sor Maria Ludovica, La Plata, Argentina., Arkachaisri T; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore.; Duke-NUS Medical School, Singapore., Magnolia MG; Paediatrics, Santa Maria della Stella Hospital, Ciconia, Orvieto (TR), Italy., Hoppenreijs E; Pediatric Rheumatology, Radboud University Medical Center/Sint Maartenskliniek, Nijmegen, Netherlands., de Roock S; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands., Wulffraat NM; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands., Ruperto N; Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Swart JF; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2021 Jun 18; Vol. 60 (6), pp. 2896-2905.