Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Boswell Hs"'
Autor:
Chonghua Yao, Boswell Hs, Y. Liu, Reuben Kapur, Sisi Chen, Mervin C. Yoder, Michihiro Kobayashi, Hal E. Broxmeyer, Rui Gao, Lindsey D. Mayo, Stephen Z. Liu
Publikováno v:
Leukemia. 32:850-854
Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53
Autor:
Hal E. Broxmeyer, Baskar Ramdas, Reuben Kapur, Heather O'Leary, Boswell Hs, Charlie Mantel, S. Cooper, Cheng-Kui Qu, Rebecca J. Chan, Maegan L. Capitano, L. Deng
Publikováno v:
Leukemia
Dipeptidylpeptidase 4 (DPP4/CD26) enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSFs), and has been implicated in cellular regulation. To better understand the role of DPP4 regulation of hemat
Autor:
Zhong Yin Zhang, Sisi Chen, Boswell Hs, Michihiro Kobayashi, James C. Mulloy, Rui Gao, Zhi-Hong Yu, Taylor A. Twiggs, Reuben Kapur, Chonghua Yao, Mervin C. Yoder, C. Mu, Yunpeng Bai, Y. Liu, Xiao-Jian Sun
Publikováno v:
Leukemia. 31:1453-1457
Autor:
Briana M. Richine, Ziyue Liu, Reuben Kapur, Elizabeth L. Virts, Baskar Ramdas, Bowling Jd, Raghuveer Singh Mali, Rebecca J. Chan, Boswell Hs, Zhong Yin Zhang, Naoye R
Publikováno v:
Leukemia
Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia
Publikováno v:
Leukemia. 11:73-85
Raised intracellular cyclic AMP (cAMP) has been demonstrated to exert an antiproliferative effect in myeloid cells. How the antiproliferative activity of cAMP is exerted in p210 BCR-ABL transformed myeloid cells was the subject of this investigation.
Publikováno v:
Blood. 88:138-145
Steel factor (SLF) acts synergistically with various hematopoietic growth factors that use the Jak-Stat pathways in vivo and in vitro, although the contribution by SLF to this pathway is unknown. We show here that SLF induces time- and dose-dependent
Publikováno v:
Europe PubMed Central
We have previously shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression induced by interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the murine stromal cell line +/+.1-LDA 11 involves activation of ph
Autor:
Boswell Hs, Reuben Kapur, Menggang Yu, Xinna Zhang, Gen-Sheng Feng, Sarah C. Nabinger, Baskar Ramdas, Shifalika Goenka, Rebecca J. Chan, George E. Sandusky, Yantao He, Bowling Jd, Xing Jun Li, Briana M. Richine, Ziyue Liu, Zhong Yin Zhang, Li-Fan Zeng, Seiji Fukuda
Publikováno v:
Leukemia
Internal tandem duplications in the fms-like tyrosine kinase receptor (FLT3-ITDs) confer a poor prognosis in acute myeloid leukemia. We hypothesized that increased recruitment of the protein tyrosine phosphatase, Shp2, to FLT3-ITDs contributes to FLT
Publikováno v:
The Journal of Experimental Medicine
Enforced expression of p210bcr-abl transforms interleukin 3 (IL-3)-dependent hematopoietic cell lines to growth factor-independent proliferation. It has been demonstrated that nonreceptor tyrosine kinase oncogenes may couple to the p21ras pathway to
Autor:
Burgess Gs, Boswell Hs, Keisuke Miyazawa, Kamran Gharehbaghi, D. S. Leibowitz, R. A. Mandanas, T Tauchi, Hiremagalur N. Jayaram
Publikováno v:
Blood. 82:1838-1847
The p21 RAS product has been implicated as part of the downstream signaling of certain nonreceptor tyrosine kinase oncogenes and several growth factor receptor-ligand interactions. We have reported that the chronic myelogenous leukemia oncogene p210