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Akademický článek

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

Publikováno v: Cell Reports, Vol 10, Iss 10, Pp 1692-1707 (2015)

Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat in maint

Externí odkaz: https://doaj.org/article/0668dfdac5754c879ffbfed4d6e834b3

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Abstract 327: High conversion library preparation with optimal hybridization capture panel design strategy in RNA-seq

Autor: Patrick J. Lau, Ashley Dvorak, Kevin Lai, Ryan Demeter, Shale Dames, Steven Henck, Katia Star, Katelyn Larkin, Bosun Min, Timothy Barnes, Manqing Hong, Jessica Sheu, Hsiao-Yun Huang, Ushati Das Chakravarty, Tzu-Chun Chen

Publikováno v: Cancer Research. 81:327-327

RNA-seq is a powerful tool to detect tissue-specific gene expression, splicing, and genetic variations associated with disease states. However, current RNA-seq approaches have limitations due to poor signal from low-abundant transcripts. Furthermore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::925526f1a1236da912f8b11b352c5054
https://doi.org/10.1158/1538-7445.am2021-327

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Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis

Autor: Michael Jeffrey Cho, Donald C. Rio, Ronaldo P. Panganiban, Bosun Min, Malik J. Francis, Siobhan E. Roche, Eileen L. Beall

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 46

In Drosophila , P-element transposition causes mutagenesis and genome instability during hybrid dysgenesis. The P-element 31-bp terminal inverted repeats (TIRs) contain sequences essential for transposase cleavage and have been implicated in DNA repa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf7082b00ebd52fb769cfd744d59469
https://doi.org/10.1073/pnas.1613508113

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Abstract 1349: Improved human exome sequencing workflow with the most complete coverage

Autor: Xiaohui Wang, Ekaterina Star, Kevin Lai, Alexandra Wang, Yu Wang, Manqing Hong, Bosun Min, Timothy Rusch, Longhui Ren, Patrick J. Lau, Jinglie Zhou, Kristina Giorda, Nick Downey, Nicole Roseman, Steven Henck, Krishnalekha Datta, Lynette Lewis, Steve Groenewold

Publikováno v: Cancer Research. 80:1349-1349

Consisting of only ~2% of the human genome, the exome accounts for ~85% of genetic disorders. Efficient sequencing of the human exome with complete and high coverage depth at low cost is invaluable for furthering research in clinical applications. ID

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bdfaa5d8c42366b8689dbb483c9d7b7
https://doi.org/10.1158/1538-7445.am2020-1349

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Enabling variant calling in challenging FFPE samples by coupling a novel library preparation chemistry with exome sequencing

Autor: Steve Groenewold, Patrick J. Lau, Ekaterina Star, Jessica Sheu, Tzu-Chun Chen, Kevin Lai, Steven Henck, Karissa Scott, Lynette Lewis, Ushati Das Chakravarty, Longhui Ren, Hsiao-Yun Huang, Xiaohui Wang, Manqing Hong, Bosun Min, Ramses Lopez, Tim Barnes, Jinglie Zhou

Publikováno v: Journal of Clinical Oncology. 38:e15584-e15584

e15584 Background: Comprehensive tumor profiling using NGS is fundamentally transforming oncology research. However, converting archival tissue samples into libraries is often challenging due to the low quantity and quality of DNA. Here we present ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::292d84a8628302a9fcf6a753be94ca95
https://doi.org/10.1200/jco.2020.38.15_suppl.e15584

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Abstract 755: AVENIO Tumor Tissue Analysis Kits performance across Illumina sequencing platforms

Autor: Isabel Soto, Lewyn Li, Cindy Choi, Garima Kushwaha, Jingchuan Li, Bosun Min, Laura Qin, Seng Salee, Liang Feng, Gregory Turenchalk, Jing Li

Publikováno v: Cancer Research. 79:755-755

Introduction: Genomic profiling of tumors is an important clinical tool for biomarker discovery and therapy selection. Tumor profiling often relies on formalin-fixed, paraffin-embedded (FFPE) tissue which is challenging because of fragmentation, cros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b66ab0741c9b6ccb276813565e50b66
https://doi.org/10.1158/1538-7445.am2019-755

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