Výsledky vyhledávání - "Bostjan Petek"

Evaluating the Impact of Physiological Properties of the Gastrointestinal Tract On Drug In Vivo Performance Using Physiologically Based Biopharmaceutics Modeling and Virtual Clinical Trials

Autor: Bostjan Petek, Aleksander Bajc, Jerneja Opara, Rebeka Jereb

Publikováno v: Journal of Pharmaceutical Sciences. 110:3069-3081

The physiological properties of the gastrointestinal tract, such as pH, fluid volume, bile salt concentration, and gastrointestinal transit time, are highly variable in vivo. These properties can affect the dissolution and absorption of a drug, depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2c80dab882b915e1be3f8af5bb65e6
https://doi.org/10.1016/j.xphs.2021.04.007

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Physiologically based absorption modeling to predict bioequivalence of controlled release and immediate release oral products

Autor: Raja Velagapudi, Bostjan Petek, Amitava Mitra, Igor Legen, Aleksander Bajc

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 134:117-125

Physiologically based absorption modeling was conducted to predict bioequivalence (BE) for immediate release (IR) and controlled release (CR) formulations. In case of the CR formulation of a BCS class 1 drug, sensitivity analyses were conducted to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80116f1f7799e27faa8ed07bd21a02dc
https://doi.org/10.1016/j.ejpb.2018.11.019

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The biorelevant simulation of gastric emptying and its impact on model drug dissolution and absorption kinetics

Autor: Rebeka Jereb, Dejan Krajcar, Helena Vrbanac, Jerneja Opara, Bostjan Petek, Sandra Berglez, Igor Legen, Jurij Trontelj

Publikováno v: European journal of pharmaceutics and biopharmaceutics, str. 113-120 : Ilustr., Vol. 149, 2020
COBISS-ID: 13176839

The highly variable physiological conditions within the gastrointestinal tract can cause variable drug release and absorption from the orally administrated dosage forms. The emptying of the gastric content is one of the most critical physiological pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b910fd4d96543e526f154b703806d03
https://plus.cobiss.net/cobiss/si/en/bib/4884849

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In vitro-In vivo Relationship and Bioequivalence Prediction for Modified-Release Capsules Based on a PBPK Absorption Model

Autor: Rebeka Jereb, Bostjan Petek, Jerneja Opara, Igor Legen, Darja Grabnar-Peklar

Publikováno v: AAPS PharmSciTech. 21(1)

A physiologically based pharmacokinetic (PBPK) absorption model was developed in GastroPlus™ based on data on intravenous, immediate-release (IR), and modified-release (MR) drug products. The predictability of the model was evaluated by comparing p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3dc2e96055010f9f62ff442f2e70b02
https://pubmed.ncbi.nlm.nih.gov/31820131

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