Zobrazeno 1 - 10
of 720
pro vyhledávání: '"Bostjan, Kobe"'
Autor:
You Lv, Jianxun Qi, Jeffrey J. Babon, Longxing Cao, Guohuang Fan, Jiajia Lang, Jin Zhang, Pengbing Mi, Bostjan Kobe, Faming Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/f60d3364073c4bd1a5bf29d76818335c
Autor:
Akansha Bhatt, Biswa P. Mishra, Weixi Gu, Mitchell Sorbello, Hongyi Xu, Thomas Ve, Bostjan Kobe
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 695-707 (2024)
The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by proteins with roles in immunity signalling pathways across phyla (from humans and plants to bacteria). Decades of research have finally led to identifying th
Externí odkaz:
https://doaj.org/article/911b32ad4e754b9396d90cf4c2e086d9
Autor:
You Lv, Jianxun Qi, Jeffrey J. Babon, Longxing Cao, Guohuang Fan, Jiajia Lang, Jin Zhang, Pengbing Mi, Bostjan Kobe, Faming Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-37 (2024)
Abstract The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as
Externí odkaz:
https://doaj.org/article/98bf3d0240a540a696df75564142d9ad
Autor:
Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 rec
Externí odkaz:
https://doaj.org/article/dcf8b7e19c924597be45dfa99851bf23
Autor:
Linhong Teng, Yuhuan Sun, Jiayi Chen, Chenghui Wang, Jonathan M. Urbach, Bostjan Kobe, Naihao Ye, Qiangcheng Zeng
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
The ROCO family is a family of GTPases characterized by a central ROC-COR tandem domain. Interest in the structure and function of ROCO proteins has increased with the identification of their important roles in human disease. Nevertheless, the functi
Externí odkaz:
https://doaj.org/article/5c74415371c24922abcab4640959cba6
Autor:
You Lv, Pengbing Mi, Jeffrey J. Babon, Guohuang Fan, Jianxun Qi, Longxing Cao, Jiajia Lang, Jin Zhang, Faming Wang, Bostjan Kobe
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107217- (2024)
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue home
Externí odkaz:
https://doaj.org/article/52be90933a344e738b1749640c6d75bf
Autor:
Susannah Holmes, Henry J. Kirkwood, Richard Bean, Klaus Giewekemeyer, Andrew V. Martin, Marjan Hadian-Jazi, Max O. Wiedorn, Dominik Oberthür, Hugh Marman, Luigi Adriano, Nasser Al-Qudami, Saša Bajt, Imrich Barák, Sadia Bari, Johan Bielecki, Sandor Brockhauser, Mathew A. Coleman, Francisco Cruz-Mazo, Cyril Danilevski, Katerina Dörner, Alfonso M. Gañán-Calvo, Rita Graceffa, Hans Fanghor, Michael Heymann, Matthias Frank, Alexander Kaukher, Yoonhee Kim, Bostjan Kobe, Juraj Knoška, Torsten Laurus, Romain Letrun, Luis Maia, Marc Messerschmidt, Markus Metz, Thomas Michelat, Grant Mills, Serguei Molodtsov, Diana C. F. Monteiro, Andrew J. Morgan, Astrid Münnich, Gisel E. Peña Murillo, Gianpietro Previtali, Adam Round, Tokushi Sato, Robin Schubert, Joachim Schulz, Megan Shelby, Carolin Seuring, Jonas A. Sellberg, Marcin Sikorski, Alessandro Silenzi, Stephan Stern, Jola Sztuk-Dambietz, Janusz Szuba, Martin Trebbin, Patrick Vagovic, Thomas Ve, Britta Weinhausen, Krzysztof Wrona, Paul Lourdu Xavier, Chen Xu, Oleksandr Yefanov, Keith A. Nugent, Henry N. Chapman, Adrian P. Mancuso, Anton Barty, Brian Abbey, Connie Darmanin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Free-electron lasers are capable of high repetition rates and it is assumed that protein crystals often do not survive the first X-ray pulse. Here the authors address these issues with a demonstration of multi-hit serial crystallography in which mult
Externí odkaz:
https://doaj.org/article/2126addb96a243bbab803f29ff675139
Autor:
Gabriel Foley, Ariane Mora, Connie M Ross, Scott Bottoms, Leander Sützl, Marnie L Lamprecht, Julian Zaugg, Alexandra Essebier, Brad Balderson, Rhys Newell, Raine E S Thomson, Bostjan Kobe, Ross T Barnard, Luke Guddat, Gerhard Schenk, Jörg Carsten, Yosephine Gumulya, Burkhard Rost, Dietmar Haltrich, Volker Sieber, Elizabeth M J Gillam, Mikael Bodén
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010633 (2022)
Ancestral sequence reconstruction is a technique that is gaining widespread use in molecular evolution studies and protein engineering. Accurate reconstruction requires the ability to handle appropriately large numbers of sequences, as well as insert
Externí odkaz:
https://doaj.org/article/6706c45e0af54c36a70246e9e790f19a
Autor:
Steven J Hancock, Alvin W Lo, Thomas Ve, Christopher J Day, Lendl Tan, Alejandra A Mendez, Minh-Duy Phan, Nguyen Thi Khanh Nhu, Kate M Peters, Amanda C Richards, Brittany A Fleming, Chyden Chang, Dalton H Y Ngu, Brian M Forde, Thomas Haselhorst, Kelvin G K Goh, Scott A Beatson, Michael P Jennings, Matthew A Mulvey, Bostjan Kobe, Mark A Schembri
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010582 (2022)
Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the urinary tract and bloodstream, but the mechanisms of gut colonisatio
Externí odkaz:
https://doaj.org/article/8db3f6a677d84c3bb2b4d5630d12441f
Autor:
Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these My
Externí odkaz:
https://doaj.org/article/5393cc79aa8d46d7b03a93a616d4e3b9